Patents by Inventor Lynn M. Tran

Lynn M. Tran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Potent inhibition of influenza virus by specifically designed short interfering RNA
    Patent number: 7304042
    Abstract: This patent application discloses siRNA sequences against the constant region of the ,8 influenza virus nucleoprotein gene comprising: (SEQ ID NO: 1) Sense strand: 5??UGAAGGAUCUUAUUUCUUCdTdT 3? (SEQ ID NO: 2) Anti sense strand: 3??dTdTACUUCCUAGAAUAAAGAAG 5? or (SEQ ID NO: 3) Sense strand: 5??UGAAGGAUCUUAUUUCUUCGGdTdT 3? (SEQ ID NO: 4) Anti sense strand: 3??dTdTACUUCCUAGAAUAAAGAAGCC 5? or (SEQ ID NO: 5) Sense strand: 5??GGAUCUUAUUUCUUCGGAGACdTdT 3? (SEQ ID NO: 6) Anti sense strand: 3??dTdTCCUAGAAUAAAGAAGCCUCUG 5? said sequences being inhibitory against influenza virus in animals including humans. The invention further includes one or more of said siRNA sequences in the form of an aqueous suspension suitable for nasal inhalation. Still further, the invention includes one or more of said siRNA sequences in the form of a plasmid expressing intracellularly in animals including humans.
    Type: Grant
    Filed: February 15, 2007
    Date of Patent: December 4, 2007
    Assignee: Cal Poly Pomona Foundation
    Inventors: Bijay K. Pal, Lynn M. Tran
  • Potent inhibition of influenza virus by specifically designed short interfering RNA
    Patent number: 7288531
    Abstract: This patent application discloses siRNA sequences against the constant region of the influenza virus nucleoprotein gene comprising: Sense strand: 5??UGAAGGAUCUUAUUUCUUCdTdT 3? (SEQ ID NO: 1) Anti sense 3??dTdTACUUCCUAGAAUAAAGAAG 5? strand: (SEQ ID NO: 2) or Sense strand: 5??UGAAGGAUCUUAUUUCUUCGGdTdT 3? (SEQ ID NO: 3) Anti sense 3??dTdTACUUCCUAGAAUAAAGAAGCC 5? strand: (SEQ ID NO: 4) or Sense strand: 5??GGAUCUUAUUUCUUCGGAGACdTdT 3? (SEQ ID NO: 5) Anti sense 3??dTdTCCUAGAAUAAAGAAGCCUCUG 5? strand: (SEQ ID NO: 6) said sequences being inhibitory against influenza virus in animals including humans. The invention further includes one or more of said siRNA sequences in the form of an aqueous suspension suitable for nasal inhalation. Still further, the invention includes one or more of said siRNA sequences in the form of a plasmid expressing intracellularly in animals including humans.
    Type: Grant
    Filed: February 15, 2007
    Date of Patent: October 30, 2007
    Assignee: Cal Poly Pomona Foundation
    Inventors: Bijay K. Pal, Lynn M. Tran
  • Potent inhibition of influenza virus by specifically designed short interfering RNA
    Patent number: 7199109
    Abstract: This patent application discloses siRNA sequences against the constant region of the influenza virus nucleoprotein gene comprising: Sense strand: 5? UGAAGGAUCUUAUUUCUUCdTdT 3? (SEQ ID NO: 1) Anti sense strand: 3? dTdTACUUCCUAGAAUAAAGAAG 5? (SEQ ID NO: 2) Sense strand: 5? UGAAGGAUCUUAUUUCUUCGGdTdT 3? (SEQ ID NO: 3) Anti sense strand: 3? dTdTACUUCCUAGAAUAAAGAAGCC 5? (SEQ ID NO: 4) Sense strand: 5? GGAUCUUAUUUCUUCGGAGACdTdT 3? (SEQ ID NO: 5) Anti sense strand: 3? dTdTCCUAGAAUAAAGAAGCCUCUG 5? (SEQ ID NO: 6) said sequences being inhibitory against influenza virus in animals including humans. The invention further includes one or more of said siRNA sequences in the form of an aqueous suspension suitable for nasal inhalation. Still further, the invention includes one or more of said siRNA sequences in the form of a plasmid expressing intracellularly in animals including humans.
    Type: Grant
    Filed: June 2, 2006
    Date of Patent: April 3, 2007
    Assignee: Cal Poly Pomona Foundation
    Inventors: Bijay K. Pal, Lynn M. Tran