Abstract: Mice are provided that comprise a reduction or deletion of ADAM6 activity from an endogenous ADAM6 locus, or that lack an endogenous locus encoding a mouse ADAM6 protein, wherein the mice comprise a sequence encoding an ADAM6 or ortholog or homolog or fragment thereof that is functional in a male mouse. In one embodiment, the sequence is an ectopic ADAM6 sequence or a sequence that confers upon a male mouse the ability to generate offspring by mating. Mice and cells with genetically modified immunoglobulin heavy chain loci that comprise an ectopic nucleotide sequence encoding a mouse ADAM6 or functional fragment or homolog or ortholog thereof are also provided.

Abstract: Mice, embryos, cells, and tissues having a restricted immunoglobulin heavy chain locus and an ectopic sequence encoding one or more ADAM6 proteins are provided. In various embodiments, mice are described that have humanized endogenous immunoglobulin heavy chain loci and are capable of expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof that is functional in a male mouse. Mice, embryos, cells, and tissues having an immunoglobulin heavy chain locus characterized by a single human VH gene segment, a plurality of human DH gene segments and a plurality of human JH gene segments and capable expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof are also provided.

Abstract: The disclosure is and includes at least an apparatus, system and method for a flexible heater sensor suitable for association with a fluid bag. The apparatus, system and method may include a conformable substrate on a ply of the fluid bag opposite a printed flexible heater; and a matched function ink set, printed onto at least one substantially planar face of the substrate.

Abstract: The disclosure is and includes at least an apparatus, system and method for a flexible heater sensor suitable for association with a fluid bag. The apparatus, system and method may include a conformable substrate on a ply of the fluid bag opposite a printed flexible heater; and a matched function ink set, printed onto at least one substantially planar face of the substrate.

Abstract: The flag pole is a mast and banner pole assembly that is adapted for use in displaying flags and banners. The flag pole is mounted to the ground through the use of a ground post such that the flag pole can be rotated using the ground post as the center of rotation. This configuration allows the position of the flag or banner to be adjusted in a manner that will control the visibility of the flag or banner. Once the flag or banner is rotated into the desired position, the flag pole can be locked in position. The banner pole is removably attached to the mast. The flag pole further comprises an acute angle which displays the flag or banner at an acute angle relative to a line perpendicular to the ground. The flag pole comprises a mast, a banner pole, a ground post, and an acute angle.

Abstract: An insulation device lays on top of an attic access, insulating the access, and prevents heat loss, heat radiation and cold or hot air from flowing into the home. Because the insulation device of the present invention lays on top of the attic access, and insulates all sides of the access at a consistent R-value, the insulation device is a more complete insulation system as compared to conventional systems that merely create a dead air space at the attic access. The insulation device may be hingedly attached at one end of the attic access to allow a user to easily open and close the insulation device accurately over the opening.

Abstract: Sealant compositions and methods which are particularly adaptable for use in detecting movement between two or more adjacent surfaces. The preferred sealant composition of the present invention is comprised of a paint base, such as a latex floor enamel, to which is added a thickening agent. One suitable thickening agent is a texture paint containing silica and silicates. When applied to a surface or series of surfaces, the sealant composition dries to a putty-like consistency. When spread over a portion of two adjacent surfaces and the joint therebetween, the paint forms a smooth continuous surface. If the two surfaces are moved with respect to one another, however, an irreparable tear occurs in the paint surface; as a result, movement between the two surfaces is readily detected. This sealant composition is particularly useful in detecting tampering with utility meters.