Patents by Inventor Lynn Thomason

Lynn Thomason has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA recombination in eukaryotic cells by the bacteriophage PHIC31 recombination system
    Patent number: 8129598
    Abstract: This invention provides methods for obtaining specific and stable integration of nucleic acids into eukaryotic cells. The invention makes use of site-specific recombination systems that use prokaryotic recombinase polypeptides, such as the ?C31 integrase, that can mediate recombination between the recombination sites, but not between hybrid recombination sites that are formed upon the recombination. Thus, the recombination is irreversible in the absence of additional factors. Eukaryotic cells that contain the recombinase polypeptides, or genes that encode the recombinases, are also provided.
    Type: Grant
    Filed: November 24, 2003
    Date of Patent: March 6, 2012
    Assignees: The Regents of the University of California, The United States of America as represented by the Secretary of Agriculture
    Inventors: David W. Ow, Richard Calendar, Lynn Thomason
  • DNA recombination in eukaryotic cells by the bacteriophage PHIC31 recombination system
    Publication number: 20050054106
    Abstract: This invention provides methods for obtaining specific and stable integration of nucleic acids into eukaryotic cells. The invention makes use of site-specific recombination systems that use prokaryotic recombinase polypeptides, such as the ?C31 integrase, that can mediate recombination between the recombination sites, but not between hybrid recombination sites that are formed upon the recombination. Thus, the recombination is irreversible in the absence of additional factors. Eukaryotic cells that contain the recombinase polypeptides, or genes that encode the recombinases, are also provided.
    Type: Application
    Filed: November 24, 2003
    Publication date: March 10, 2005
    Inventors: David Ow, Richard Calendar, Lynn Thomason
  • DNA recombination in eukaryotic cells by the bacteriophage PHIC31 recombination system
    Patent number: 6746870
    Abstract: This invention provides methods for obtaining specific and stable integration of nucleic acids into eukaryotic cells. The invention makes use of site-specific recombination systems that use prokaryotic recombinase polypeptides, such as the &PHgr;C31 integrase, that can mediate recombination between the recombination sites, but not between hybrid recombination sites that are formed upon the recombination. Thus, the recombination is irreversible in the absence of additional factors. Eukaryotic cells that contain the recombinase polypeptides, or genes that encode the recombinases, are also provided.
    Type: Grant
    Filed: July 21, 2000
    Date of Patent: June 8, 2004
    Assignees: The Regents of the University of California, The United States of America as represented by the Secretary of Agriculture
    Inventors: David W. Ow, Richard Calendar, Lynn Thomason