Abstract: The invention provides a system and method for plasma coating of an optical lens, particularly lenses made of silicone-containing polymer. A system of the invention comprises an entry chamber, a coating chamber downstream from the entry chamber, and an exit chamber downstream from the coating chamber. The coating chamber includes a pair of spaced apart electrodes disposed therein. A system of the invention is configured in a way so that a lens may enter, pass through and exit the system without requiring the coating chamber to be repeatedly pressurized and depressurized.

Abstract: The present invention provides a method for forming on a medical device, preferably an ophthalmic lens, more preferably a contact lens, a diffusion-controllable coating capable of controlling the out-diffusion or release of guest materials from the medical device. The method of the invention comprises: (1) applying one layer of clay and optionally one or more layers of polyionic materials onto the medical device; or (2) applying alternatively a layer of a first polyionic material and a layer of a second polyionic material having charges opposite of the charges of the first polyionic material onto the medical device and releasing the coated medical device into a releasing medium having a composition capable of imparting a desired permeability to the diffusion-controllable coating on the medical device.

Abstract: The invention provide a method for applying a coating to an ophthalmic lens or a mold for making the ophthalmic lens or a medical device other than ophthalmic lens. The method comprises spraying at least one layer of a coating liquid onto an ophthalmic lens using a spraying process selected from the group consisting of an air-assisted atomization and dispensing process, an ultrasonic-assisted atomization and dispensing process, a piezoelectric assisted atomization and dispensing process, an electro-mechanical jet printing process, a piezo-electric jet printing process, a piezo-electric with hydrostatic pressure jet printing process, and a thermal jet printing process. The coating can comprise a property/functionality pattern or a color image or combination of both.

Abstract: The present invention provides a method for preparing a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating on a medical device, wherein the antimicrobial metal-containing LbL coating comprises at least one layer of a negatively charged polyionic material having —COOAg groups and/or silver nanoparticles formed by reducing Ag+ ions associated with the —COO? groups of the negatively charged polyionic material. In addition, the present invention provides a medical device prepared according to a method of the invention.

Abstract: The present invention provides a medical device, preferably a contact lens, which a core material and an antimicrobial metal-containing LbL coating that is not covalently attached to the medical device and can impart to the medical device an increased hydrophilicity. The antimicrobial metal-containing coating on a contact lens of the invention has a high antimicrobial efficacy against microorganisms including Gram-positive and Gram-negative bacterial and a low toxicity, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating thereon.

Abstract: An ophthalmic solution for improving the exchange of fluid in the area outside a hydrogel contact lens with the fluid in the area underneath the hydrogel contact lens comprising:(a) 0.0005% by weight to an amount of a hydrogel contact lens flattening agent equivalent to 330 milliosmoles/kg;(b) an amount of a viscosity enhancing agent sufficient to cause the composition to have a Brookfield relative viscosity of 3 to 50 cps; and(c) an amount of an ionic salt sufficient to render the solution substantially isotonic.The invention also includes a method for improving the exchange of fluid in the area outside a hydrogel contact lens with the fluid in the area underneath the hydrogel contact lens in a human eye comprising adding to said eye an effective amount of such ophthalmic solutions.

Abstract: An opthalmic cleaning composition for cleaning a contact lens comprising an effective amount of a water soluble particulate compound for removing proteinaceous, lipid and other non-proteinaceous deposits on the contact lens, wherein the particulate compound is suspended in a predominately non-aqueous water-miscible organic liquid medium which is substantially a non-solvent for the particulate compound, and a method of cleaning a contact lens employing such composition.