Patents by Inventor Lynne Elizabeth Wagoner

Lynne Elizabeth Wagoner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for predicting relative efficacy of a beta blocker therapy based on a B1-adrenergic receptor polymorphism
    Patent number: 7449292
    Abstract: Methods and compositions for the detection, diagnosis, and prevention of cardiac conditions are provided. Polymorphisms of ?1-adrenergic receptor are provided. The Gly389 ?1-adrenergic receptor variants are not as responsive to treatment ? blockers such as carvedilol, metoprolol or bisoprol. Thus, genotyping ?1-adrenergic receptor polymorphisms is useful for predicting relative responsiveness to treatment with beta blockers. The Gly389 polymorphism also may be used, alone or in conjunction with other adrenergic receptor polymorphisms, to predict relative risk of developing cardiovascular diseases such as heart failure or to predict relative survival rate in patients with heart failure or other cardiovascular diseases. Also provided are transgenic mice and transgenic cells expressing the ?1-adrenergic receptor polymorphisms, and their use in identifying therapeutic agents.
    Type: Grant
    Filed: September 13, 2004
    Date of Patent: November 11, 2008
    Assignee: University of Cincinnati
    Inventors: Stephen Bryant Liggett, Lynne Elizabeth Wagoner