Patents by Inventor Lysle Kevin Lewis

Lysle Kevin Lewis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Systems for in vivo site-directed mutagenesis using oligonucleotides
    Patent number: 7314712
    Abstract: This disclosure provides several methods to generate nucleic acid mutations in vivo, for instance in such a way that no heterologous sequence is retained after the mutagenesis is complete. The methods employ integrative recombinant oligonucleotides (IROs). Specific examples of the described mutagenesis methods enable site-specific point mutations, deletions, and insertions. Also provided are methods that enable multiple rounds of mutation and random mutagenesis in a localized region. The described methods are applicable to any organism that has a homologous recombination system.
    Type: Grant
    Filed: July 26, 2002
    Date of Patent: January 1, 2008
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Francesca Storici, Lysle Kevin Lewis, Michael A. Resnick
  • Systems for in vivo site-directed mutagenesis using oligonucleotides
    Publication number: 20040171154
    Abstract: This disclosure provides several methods to generate nucleic acid mutations in vivo, for instance in such a way that no heterologous sequence is retained after the mutagenesis is complete. The methods employ integrative recombinant oligonucleotides (IROs). Specific examples of the described mutagenesis methods enable site-specific point mutations, deletions, and insertions. Also provided are methods that enable multiple rounds of mutation and random mutagenesis in a localized region. The described methods are applicable to any organism that has a homologous recombination system.
    Type: Application
    Filed: January 26, 2004
    Publication date: September 2, 2004
    Inventors: Francesca Storici, Lysle Kevin Lewis, Michael A. Resnick