Patents by Inventor M. Anthony Moody

M. Anthony Moody has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HIV-1 neutralizing antibodies and uses thereof
    Patent number: 11944681
    Abstract: The invention is directed to HIV-1 neutralizing antibodies and methods for their uses.
    Type: Grant
    Filed: June 24, 2021
    Date of Patent: April 2, 2024
    Assignees: Duke University, University of Maryland
    Inventors: Barton F. Haynes, Hua-Xin Liao, M. Anthony Moody, LaTonya Williams, Kevin J. Wiehe, Gilad Adi Ofek
  • Methods of inhibiting complement factor H (CFH) comprising administering an antibody that binds CFH
    Patent number: 11897946
    Abstract: Disclosed herein are Complement factor H (CFH) inhibitors, such as anti-CFH antibodies and small molecules, and methods of using said inhibitors.
    Type: Grant
    Filed: August 26, 2021
    Date of Patent: February 13, 2024
    Assignee: Duke University
    Inventors: Edward F. Patz, Jr., Michael J. Campa, Elizabeth Gottlin, Barton F. Haynes, Hua-Xin Liao, M. Anthony Moody
  • HIV-1 NEUTRALIZING ANTIBODIES AND USES THEREOF
    Publication number: 20220096632
    Abstract: The invention is directed to HIV-1 neutralizing antibodies and methods for their uses.
    Type: Application
    Filed: June 24, 2021
    Publication date: March 31, 2022
    Inventors: Barton F. HAYNES, Hua-Xin LIAO, M. Anthony MOODY, LaTonya WILLIAMS, Kevin J. WIEHE, Gilad Adi OFEK
  • INHIBITORS OF COMPLEMENT FACTOR H
    Publication number: 20210395353
    Abstract: Disclosed herein are Complement factor H (CFH) inhibitors, such as anti-CFH antibodies and small molecules, and methods of using said inhibitors.
    Type: Application
    Filed: August 26, 2021
    Publication date: December 23, 2021
    Inventors: Edward F. Patz, JR., Michael J. Campa, Elizabeth Gottlin, Barton F. Haynes, Hua-Xin Liao, M. Anthony Moody
  • Anti-complement factor H antibodies
    Patent number: 11136380
    Abstract: Disclosed herein are Complement factor H (CFH) inhibitors, such as anti-CFH antibodies and small molecules, and methods of using said inhibitors.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: October 5, 2021
    Assignee: Duke University
    Inventors: Edward F. Patz, Jr., Michael J. Campa, Elizabeth Gottlin, Barton F. Haynes, Hua-Xin Liao, M. Anthony Moody
  • Methods for reducing HIV-1 mother-to-child transmission by inducing V3-specific or CD4 binding site-specific antibodies
    Patent number: 11077130
    Abstract: The invention provides compositions and methods to induce and boost antibody response, including but not limited to IgG responses binding to HIV-1 in a subject in need thereof, wherein the induced/boosted plasma level of the antibody responses, for example V3 and/or CD4 binding site antibody responses, is over a threshold level and is associated with reduced risk of maternal-to-child-transmission (MTCT) of HIV-1.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: August 3, 2021
    Assignee: DUKE UNIVERSITY
    Inventors: Barton F. Haynes, Sallie Permar, M. Anthony Moody, Feng Gao, Hua-Xin Liao, Georgia Tomaras, David C. Montefiori
  • HIV-1 neutralizing antibodies and uses thereof
    Patent number: 11071783
    Abstract: The invention is directed to HIV-1 neutralizing antibodies and methods for their uses.
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: July 27, 2021
    Assignees: DUKE UNIVERSITY, UNIVERSITY OF MARYLAND, COLLEGE PARK
    Inventors: Barton F. Haynes, Hua-Xin Liao, M. Anthony Moody, LaTonya Williams, Kevin J. Wiehe, Gilad Adi Ofek
  • INHIBITORS OF COMPLEMENT FACTOR H
    Publication number: 20190315842
    Abstract: Disclosed herein are Complement factor H (CFH) inhibitors, such as anti-CFH antibodies and small molecules, and methods of using said inhibitors.
    Type: Application
    Filed: November 20, 2018
    Publication date: October 17, 2019
    Inventors: Edward F. Patz, Jr., Michael J. Campa, Elizabeth Gottlin, Barton F. Haynes, Hua-Xin Liao, M. Anthony Moody
  • HIV-1 neutralizing antibodies and uses thereof (V3 antibodies)
    Patent number: 10344077
    Abstract: The invention is directed to HIV-1 neutralizing antibodies, CD4 binding site and V3 glycan antibodies, and methods for their uses.
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: July 9, 2019
    Assignee: DUKE UNIVERSITY
    Inventors: Barton F. Haynes, Ryan Meyerhoff, M. Anthony Moody, Hua-Xin Liao, Todd Bradley, Mattia Bonsignori
  • HIV-1 NEUTRALIZING ANTIBODIES AND USES THEREOF
    Publication number: 20180256719
    Abstract: The invention is directed to HIV-1 neutralizing antibodies and methods for their uses.
    Type: Application
    Filed: March 21, 2016
    Publication date: September 13, 2018
    Applicants: Duke University, University of Maryland, College Park
    Inventors: Barton F. HAYNES, Hua-Xin LIAO, M. Anthony MOODY, LaTonya WILLIAMS, Kevin J. WIEHE, Gilad Adi OFEK
  • HIV-1 NEUTRALIZING ANTIBODIES AND USES THEREOF (V3 ANTIBODIES)
    Publication number: 20180072797
    Abstract: The invention is directed to HIV-1 neutralizing antibodies, CD4 binding site and V3 glycan antibodies, and methods for their uses.
    Type: Application
    Filed: March 21, 2016
    Publication date: March 15, 2018
    Inventors: Barton F. HAYNES, Ryan MEYERHOFF, M. Anthony MOODY, Hua-Xin LIAO, Todd BRADLEY, Mattia BONSIGNORI
  • COMPOSITIONS AND METHODS FOR TRANSIENT IMMUNE RESPONSE MODULATION DURING VACCINATION
    Publication number: 20170216426
    Abstract: In certain aspects the invention provides a selection of HIV-1 envelopes suitable for use as immunogens, and methods of using these immunogens to induce neutralizing antibodies. In certain embodiments, the immunogens are designed to trimerize. In other embodiments, the immunogenic compositions and methods comprise at least one agent for transient immune response modulation during vaccination.
    Type: Application
    Filed: September 28, 2015
    Publication date: August 3, 2017
    Inventors: Barton F. HAYNES, Garnett KELSOE, Masayuki KURAOKA, M. Anthony MOODY, Hua-Xin LIAO, Laurent VERKOCZY
  • HIV-1 MOTHER-TO-CHILD TRANSMISSION CORRELATES OF PROTECTION AND VACCINE
    Publication number: 20160339051
    Abstract: The invention provides compositions and methods to induce and boost antibody response, including but not limited to IgG responses binding to HIV-1 in a subject in need thereof, wherein the induced/boosted plasma level of the antibody responses, for example V3 and/or CD4 binding site antibody responses, is over a threshold level and is associated with reduced risk of maternal-to-child-transmission (MTCT) of HIV-1.
    Type: Application
    Filed: September 26, 2014
    Publication date: November 24, 2016
    Inventors: Barton F. Haynes, Sallie Permar, M. Anthony Moody, Feng Gao, Hua-Xin Liao, Georgia Tomaras, David C. Montefiori
  • HUMAN MONOCLONAL ANTIBODIES
    Publication number: 20160244510
    Abstract: The present invention relates, in general, to HIV-1-reactive antibodies and, in at least certain specific embodiments, to broadly neutralizing antibodies (bnAbs) (and fragments and derivatives thereof) and to compositions comprising same. The invention further relates to methods of using such bnAbs (and fragments and derivatives thereof) and compositions in immunotherapy regimens (e.g., passive immunotherapy regimens). The antibodies (and fragments and derivatives thereof) disclosed herein can also be used in methods of identifying candidate immunogens for use in inducing an immune response against HIV-1 in a mammal (e.g., a human). The invention also relates to such methods and to immunogens so identified.
    Type: Application
    Filed: September 26, 2014
    Publication date: August 25, 2016
    Inventors: M Anthony Moody, Hua-Xin Liao, Barton F Haynes, Lynn Morris
  • Adjuvant
    Patent number: 8926995
    Abstract: The present invention relates, in general, to human immunodeficiency virus (HIV-1) and, in particular, to a method of enhancing an immune response to an HIV-1 immunogen, and to compounds and compositions suitable for use in such a method.
    Type: Grant
    Filed: November 23, 2011
    Date of Patent: January 6, 2015
    Assignee: Duke University
    Inventors: Barton F. Haynes, Laurent Verkoczy, M. Anthony Moody, Matt T. Holl, Masayuki Kuraoka, Garnett Kelsoe
  • HERPES SIMPLEX VIRUS
    Publication number: 20140302062
    Abstract: The present invention relates, in general to herpes simplex virus (HSV) and, particular, to antibodies that are specific for glycoprotein D (gD) of HSV. The invention also relates to prophylactic and therapeutic uses of such antibodies.
    Type: Application
    Filed: April 9, 2012
    Publication date: October 9, 2014
    Applicants: U.S. ARMY MEDICAL RESEARCH AND MATERIEL COMMAND, DUKE UNIVERSITY
    Inventors: Barton F. Haynes, Hua-Xin Liao, M. Anthony Moody, Georgia D. Tomaras, Jerome Kim, Nelson Michael
  • HIV-1 ANTIBODIES
    Publication number: 20120269821
    Abstract: The present invention relates, in general, to HIV-1 antibodies and, in particular, to broadly neutralizing HIV-1 antibodies that target the gp41 membrane-proximal external region (MPER).
    Type: Application
    Filed: December 8, 2011
    Publication date: October 25, 2012
    Inventors: Barton F. Haynes, Hua-Xin Liao, M. Anthony Moody, Lynn Morris, Salim S. Abdool Karim
  • ANTI-LIPID ANTIBODIES
    Publication number: 20110318360
    Abstract: The present invention relates, in general, to anti-lipid antibodies and, in particular, to methods of inhibiting HIV-I infection using anti-lipid (e.g. anti-phospholipid) antibodies.
    Type: Application
    Filed: September 8, 2009
    Publication date: December 29, 2011
    Applicant: DUKE UNIVERSITY
    Inventors: Barton F. Haynes, M. Anthony Moody, Bua-Xin Liao
  • Anti-lipid antibodies
    Publication number: 20110305700
    Abstract: The present invention relates, in general, to anti-lipid antibodies and, in particular, to methods of inhibiting HIV-1 infection using anti-lipid (e.g. antiphospholipid) antibodies.
    Type: Application
    Filed: April 20, 2011
    Publication date: December 15, 2011
    Applicant: DUKE UNIVERSITY
    Inventors: Barton F. Haynes, Hua-Xin Liao, M. Anthony Moody
  • METHODS OF TREATING AND PROTECTING AGAINST HUMAN IMMUNODEFICIENCY VIRUS
    Publication number: 20110159037
    Abstract: The present invention relates, in general, to human immunodeficiency virus (HIV), and, in particular, to a method of inducing neutralizing antibodies against HIV, to a method of inducing antibodies protective against HIV and to compounds and compositions suitable for use in such methods.
    Type: Application
    Filed: August 22, 2008
    Publication date: June 30, 2011
    Applicant: DUKE UNIVERISTY
    Inventors: Munir S. Alam, Hua-xin Liao, Barton F. Haynes, M. Anthony Moody