Abstract: Apparatus and a method for installing a sensor in connection with relatively movable members for sensing relative position thereof without adjustment, the sensor including a body mountable in a predetermined position on a first of the members, and a coupler being adjustably connectable to a second of the members and connectable in predetermined relation to an input of the sensor for coupling the input to the second member. The coupler is adjustably connectable to the second member in a predetermined relation to the first member such that when the input is connected to the coupler and the body is mounted in the predetermined position on the first member, the input and the body portion will be relatively positioned such that the sensor will provide a predetermined signal when the first and second members are in predetermined relative position.

Abstract: The present invention is directed to certain cinnoline compounds that are PDE10 inhibitors, pharmaceutical compositions containing such compounds and process for preparing such compounds. The invention is also directed to methods of treating diseases treatable by modulation of PDE10 enzyme, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.

Abstract: Certain substituted imidazo[1,2-a]pyrazines and the pharmaceutically-acceptable salts thereof, are provided herein. Pharmaceutical compositions containing one or more compound of Formula I, or a pharmaceutically acceptable salt of such compounds, and one or more pharmaceutically acceptable carriers, excipients, or diluents, are also provided herein. Methods of treating patients suffering from certain diseases and disorders responsive to EphB4 kinase modulation, which comprise administering to such patients an amount of a compound of Formula I effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include cancer, including breast neoplasia, endometrial cancer, colon cancer, and neck squamous cell carcinoma. Thus methods of treatment include administering a sufficient amount of a compound of the invention to decrease the symptoms or slow the progression of these diseases or disorders.