Patents by Inventor M. Dominic Ryan

M. Dominic Ryan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystal structure of angiotensin-converting enzyme-related carboxypeptidase
    Publication number: 20040209344
    Abstract: The invention relates to molecules or molecular complexes which comprise binding pockets of angiotensin-converting enzyme-related carboxypeptidase or its homologues. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to angiotensin-converting enzyme-related carboxypeptidase protein or homologues thereof. The invention also relates to crystallizable compositions and crystals comprising angiotensin-converting enzyme-related carboxypeptidase protein or angiotensin-converting enzyme-related carboxypeptidase protein complexes.
    Type: Application
    Filed: September 9, 2003
    Publication date: October 21, 2004
    Inventors: Michael W. Pantoliano, M. Dominic Ryan, Bart Lee Staker, G. Sridhar Prasad, Jin Tang, Saurabh Prabhakar Menon, Paul S. Towler, David H. Williams, Martin Fisher
  • Compounds and methods
    Publication number: 20040192914
    Abstract: Disclosed are compounds of the formula: 1
    Type: Application
    Filed: April 9, 2004
    Publication date: September 30, 2004
    Inventors: Lara S Kallander, M Dominic Ryan, Scott K Thompson
  • 1,4,4-(trisubstituted)cyclohexane monomers and related compounds
    Patent number: 5990119
    Abstract: Novel compounds of formula I are described herein. These compounds inhibit the production of Tumor Necrosis Factor and are useful in the treatment of disease states mediated or exacerbated by TNF production; these compounds are also useful in the mediation or inhibition of enzymatic or catalytic activity of phosphodiesterase IV.
    Type: Grant
    Filed: June 23, 1997
    Date of Patent: November 23, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Siegfried B. Christensen, IV, Joseph M. Karpinski, M. Dominic Ryan, Paul E. Bender
  • 4,4-(disubstituted)cyclohexan-1-ols monomers and related compounds
    Patent number: 5977122
    Abstract: The present invention relates to novel 4,4-(disubstituted)cyclohexan-1-ols monomers and related compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and inflammatory diseases and for inhibiting the production to Tumor necrosis Factor (TNF).
    Type: Grant
    Filed: December 2, 1997
    Date of Patent: November 2, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Siegfried B. Christensen, Joseph M. Karpinski, M. Dominic Ryan, Paul E. Bender
  • 1,3,3-(Trisubstituted)cyclohexanemonomers and related compounds
    Patent number: 5900417
    Abstract: This invention relates to certain 1,3,34-(trisubstituted)cyciohexane monomers and related compound which are useful in treating allergic and inflammatory diseases and for inhibiting the production of Tumor Necrosis Factor (TNF).
    Type: Grant
    Filed: February 27, 1996
    Date of Patent: May 4, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Siegfried B. Christensen, IV, Joseph M. Karpinski, M. Dominic Ryan, Paul E. Bender
  • 3,3-(disubstituted)cyclohexan-1-one monomers and related compounds
    Patent number: 5892098
    Abstract: This invention relates to derivatives of 3,3-(disubstituted)cyclohexan-1-one monomers and related compounds which are useful for treating allergic and inflammatory diseases.
    Type: Grant
    Filed: April 15, 1997
    Date of Patent: April 6, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Siegfried B. Christensen, IV, Joseph M. Karpinski, M. Dominic Ryan, Paul E. Bender
  • 4,4-(disubstituted)cyclohexan-1-ols monomers and related compounds
    Patent number: 5891883
    Abstract: The present invention relates to 4,4(disubstituted)cyclohexan-1-ol monomers and related compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and inflammatory diseases and for inhibiting the production of Tumor Necrosis Factor (TNF).
    Type: Grant
    Filed: September 11, 1997
    Date of Patent: April 6, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Siegfried B. Christensen, IV, Joseph M. Karpinski, M. Dominic Ryan, Paul E. Bender
  • 3,3-(disubstituted)cyclohexan-1-carboxylate monomers and related compounds
    Patent number: 5869677
    Abstract: The present invention relates to novel 3,3-(disubstituted)cyclohexan-1-carboxylate monomers and related compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and inflammatory diseases and for inhibiting the production of Tumor Necrosis Factor (TNF).
    Type: Grant
    Filed: February 27, 1996
    Date of Patent: February 9, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Siegfried B. Christensen, IV, Joseph M. Karpinski, M. Dominic Ryan, Paul E. Bender
  • 3,3-(disubstituted) cyclohexan-1-ol monomers and related compounds
    Patent number: 5866616
    Abstract: The present invention relates to novel 3,3-(disubstituted)cyclohexan-1-ol monomers and related compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and inflammatory diseases and for inhibiting the production of Tumor Necrosis Factor (TNF).
    Type: Grant
    Filed: June 23, 1997
    Date of Patent: February 2, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Siegfried B. Christensen, IV, Joseph M. Karpinski, M. Dominic Ryan, Paul E. Bender
  • 4,4-(disubstituted)cyclohexan-1-carboxylate monomers and related compounds
    Patent number: 5863926
    Abstract: The present invention relates to novel 4,4-(disubstituted)cyclohexan-1-carboxylate monomers and related compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and inflammatory diseases and for inhibiting the production of Tumor Necrosis Factor (TNF).
    Type: Grant
    Filed: October 6, 1997
    Date of Patent: January 26, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Siegfried B. Christensen, IV, Joseph M. Karpinski, M. Dominic Ryan, Paul E. Bender
  • 4,4-(disubstituted) cyclohexan-1-one monomers and related compounds
    Patent number: 5861421
    Abstract: This invention relates to derivatives of 4,4-(disubstituted)cyclohexan-1-ones and related compounds which are useful for treating allergic and inflammatory diseases.
    Type: Grant
    Filed: June 23, 1997
    Date of Patent: January 19, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Siegfried B. Christensen, IV, Joseph M. Karpinski, M. Dominic Ryan, Paul E. Bender
  • 1,3,3-(trisubstituted)cyclohex-1-ene monomers and related compounds
    Patent number: 5646158
    Abstract: This invention relates to certain 1,3,3-(trisubstituted)cyclohex-1-ene monomers and related compounds which are useful in treating allergic and inflammatory diseases and for inhibiting the production of Tumor Necrosis Factor (TNF).
    Type: Grant
    Filed: February 27, 1996
    Date of Patent: July 8, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: Siegfried B. Christensen, IV, Joseph M. Karpinski, M. Dominic Ryan, Paul E. Bender