Patents by Inventor M. Edward Medof

M. Edward Medof has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS OF TREATING T CELL MEDIATED DISORDER
    Publication number: 20120219566
    Abstract: A method of generating a CD4+FoxP3+ Treg cell, the method includes administering at least one complement antagonist to a naive CD4+ T cell at an amount effective to substantially inhibits C3a receptor (C3aR) and/or C5a receptor (C5aR) signal transduction in the CD4+ T cell, induce TGF-?1 expression of the CD4+ T cell, and induce differentiation of the of the naive CD4+ T cell into a CD4+FoxP3+ Treg cell.
    Type: Application
    Filed: November 4, 2010
    Publication date: August 30, 2012
    Inventors: M. Edward Medof, Feng Lin, Michael G. Strainic
  • METHOD OF TREATING T CELL MEDIATED DISORDERS
    Publication number: 20110182910
    Abstract: A method of treating a T-cell mediated disorders in a tissue includes administering to the tissue of the subject a therapeutically effective amount of a complement antagonist that substantially reduces T-cell differentiation or t-cell inflammatory cytokine generation.
    Type: Application
    Filed: March 6, 2009
    Publication date: July 28, 2011
    Inventors: M. Edward Medof, Michael G. Strainic, Kristina V. Thomas, Jodi Arth, Fenqgi An, Juang Huang
  • METHOD OF TREATING CANCER
    Publication number: 20110135656
    Abstract: A method for inducing apoptosis of a neoplastic cell expressing C3aR or C5aR includes administering at least one complement antagonist to the cell so that the at least one complement antagonist substantially reduces or inhibits the activity of protein kinase B in the neoplastic cell.
    Type: Application
    Filed: March 2, 2009
    Publication date: June 9, 2011
    Inventors: M. Edward Medof, Michael G. Strainic, Young A Choi
  • METHOD FOR TREATING DISORDERS RELATED TO COMPLEMENT ACTIVATION
    Publication number: 20100063146
    Abstract: A method for treating or preventing a complement activated T-cell mediated disorder in a subject includes administering a therapeutically effective amount of a pharmaceutical composition to the subject. The pharmaceutical composition includes at least one amidine compound or pharmaceutically acceptable salt.
    Type: Application
    Filed: November 7, 2007
    Publication date: March 11, 2010
    Inventors: M. Edward Medof, Feng Lin, Qing Li