Abstract: The present disclosure provides a tissue-removing catheter for removing tissue in a body lumen. The tissue-removing catheter includes an elongate drive member and a tissue-removing element. The elongate drive member has proximal and distal ends with a length and a longitudinal axis extending between the proximal and distal ends. The elongate drive member is sized and shaped to be received in the body lumen and rotates about its longitudinal axis. The elongate drive member further includes first and second longitudinal portions. The first longitudinal portion is proximal to and stiffer than the second longitudinal portion. The tissue-removing element is operatively coupled to the distal end of the elongate drive member and rotates by the elongate drive member to remove the tissue in the body lumen.

Abstract: A clutch assembly or module that includes multiple components and one-way clutches. The clutch assembly or module functions as a releasable torque transmitting mechanism that provides a mechanical engagement between mating parts wherein the multiple components and one-way clutches cooperate to control the torque flow path between a drive or input member and a driven or output member.

Abstract: A coupling and control assembly includes first and second rotatable coupling members. The first coupling member has a first coupling face with locking formations, and the second coupling member has a second coupling face with pockets and in opposition with the first coupling face of the first coupling member and a third face spaced from the second coupling face and with passages communicating with the pockets. Locking members in the pockets transmit torque between the first and second coupling members. A stator includes an electromagnetic source, and a translator is translatable, rotatable, and coupled to the second coupling member to be rotatable therewith. The translator may include springs in the passages to actuate the plurality of locking members, or a permanent magnetic source cooperative with the electromagnetic source to translate the translator. An apertured retainer plate may be coupled to the second coupling member to facilitate pivoting of the plurality of locking members.

Abstract: A clutch assembly or module that includes multiple components and one-way clutches. The clutch assembly or module functions as a releasable torque transmitting mechanism that provides a mechanical engagement between mating parts wherein the multiple components and one-way clutches cooperate to control the torque flow path between a drive or input member and a driven or output member.

Abstract: A support frame is provided that includes an upper plate, a lower plate, side support members, an upper support structure, and a lower support structure. The upper plate defines a first inner surface and an opposed first outer surface. The lower plate defines a second inner surface and an opposed second outer surface. A TEM test space is defined between the first inner surface and the second inner surface. The side support members are disposed between the upper plate and the lower plate proximate a periphery of the test space. The upper support structure is coupled to and supports the upper plate. The upper support structure extends from the first outer surface of the upper plate. The lower support structure is coupled to and supports the lower plate. The lower support structure extends from the second outer surface of the lower plate.

Abstract: Vehicle wheels and methods of making vehicle wheels are provided. A vehicle wheel comprises a generally annular first region, a second region, and a flange extension. The first region comprises an inner surface and an outer surface comprising a tire bead seat. The second region extends radially inwardly from the first region. The second region is configured to mount to a vehicle axle. The flange extension extends from the first region in a direction away from the second region. The flange extension comprises a first extension end integral with the first region, a second extension end, and an elongate portion intermediate the first extension end and the second extension end. The elongate portion comprising a first portion with a thickness less than a thickness of the second extension end.

Abstract: A coupling and control assembly includes first and second rotatable coupling members. The first coupling member has a first coupling face with locking formations, and the second coupling member has a second coupling face with pockets and in opposition with the first coupling face of the first coupling member and a third face spaced from the second coupling face and with passages communicating with the pockets. Locking members in the pockets transmit torque between the first and second coupling members. A stator includes an electromagnetic source, and a translator is translatable, rotatable, and coupled to the second coupling member to be rotatable therewith. The translator may include springs in the passages to actuate the plurality of locking members, or a permanent magnetic source cooperative with the electromagnetic source to translate the translator. An apertured retainer plate may be coupled to the second coupling member to facilitate pivoting of the plurality of locking members.

Abstract: An electro-dynamic coupling and control assembly and a switchable linear actuator device are provided. The assembly has first and second coupling members each of which is supported for rotation about a common rotational axis and at least one locking member for selectively mechanically coupling the coupling members together. The device includes a stator structure including at least one electromagnetic source and a translator structure configured to be coupled to the second coupling member to rotate therewith. The translator structure includes at least one plunger which is elastically deformable in an axial direction to provide the device with compliance. Each plunger has a free end portion configured to move within a passage to engage and actuate a locking member within a pocket in the second coupling member.

Abstract: An electro-dynamic coupling and control assembly and a switchable linear actuator device are provided. The assembly has first and second coupling members each of which is supported for rotation about a common rotational axis and at least one locking member for selectively mechanically coupling the coupling members together. The device includes a stator structure including at least one electromagnetic source and a translator structure configured to be coupled to the second coupling member to rotate therewith. The translator structure includes at least one plunger which is elastically deformable in an axial direction to provide the device with compliance. Each plunger has a free end portion configured to move within a passage to engage and actuate a locking member within a pocket in the second coupling member.

Abstract: A mobile fixture includes a movable base, a support platform, an adaptor interface, at least one sensor, and a controller. The movable base is configured to travel over a floor. The support platform is articulable with respect to the base. The adaptor interface moves with the support platform, and is configured to mechanically interface with an attachment member. The at least one sensor is coupled to the adaptor interface and is configured to detect at least one of a force or movement resulting from an interaction between the adaptor interface and the attachment member. The controller is operably coupled to the movable base, support platform, and at least one sensor, and is configured to control movement of at least one of the movable base or support platform responsive to the at least one of the force or movement detected by the at least one sensor.

Abstract: A source assembly is provided for a transverse electromagnetic (TEM) system. The source assembly includes a first guide and a second guide. The first guide is configured to receive a signal from a supply, and includes a first shell defining a first cavity. The first guide is configured to extend proximate an upper plate of the TEM system. The second guide is configured to receive a reference signal from the supply. The second guide includes a second shell defining a second cavity. The second guide is configured to extend proximate a lower plate of the TEM system, and is spaced a distance from the first guide to define a gap having a gap width. At least one of the first guide or second guide includes an access opening configured to provide access to at least one of the first cavity or the second cavity.

Abstract: Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. In addition, species of tricyclic gyrase inhibitors compounds are also disclosed herein. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.

Abstract: A mobile fixture includes a movable base, a support platform, an adaptor interface, at least one sensor, and a controller. The movable base is configured to travel over a floor. The support platform is articulable with respect to the base. The adaptor interface moves with the support platform, and is configured to mechanically interface with an attachment member. The at least one sensor is coupled to the adaptor interface and is configured to detect at least one of a force or movement resulting from an interaction between the adaptor interface and the attachment member. The controller is operably coupled to the movable base, support platform, and at least one sensor, and is configured to control movement of at least one of the movable base or support platform responsive to the at least one of the force or movement detected by the at least one sensor.

Abstract: An assembly is provided for a transverse electromagnetic (TEM) system. The assembly includes a support frame and at least one resistive sheet. The support frame includes an upper plate and a lower plate. The upper plate defines a first inner surface and an opposed first outer surface. The lower plate defines a second inner surface and an opposed second outer surface. The at least one resistive sheet is coupled to at least one of the upper plate or the lower plate, and extends parallel to the upper plate and lower plate from an exterior of the support frame. The resistive sheet has an inner end disposed proximate the at least one of the upper plate or lower plate and an outer end disposed opposite the inner end, and has a variable resistance that is greater at the outer end than at the inner end.

Abstract: An assembly is provided for a transverse electromagnetic (TEM) system. The assembly includes a support frame and at least one resistive sheet. The support frame includes an upper plate and a lower plate. The upper plate defines a first inner surface and an opposed first outer surface. The lower plate defines a second inner surface and an opposed second outer surface. The at least one resistive sheet is coupled to at least one of the upper plate or the lower plate, and extends parallel to the upper plate and lower plate from an exterior of the support frame. The resistive sheet has an inner end disposed proximate the at least one of the upper plate or lower plate and an outer end disposed opposite the inner end, and has a variable resistance that is greater at the outer end than at the inner end.

Abstract: A source assembly is provided for a transverse electromagnetic (TEM) system. The source assembly includes a first guide and a second guide. The first guide is configured to receive a signal from a supply, and includes a first shell defining a first cavity. The first guide is configured to extend proximate an upper plate of the TEM system. The second guide is configured to receive a reference signal from the supply. The second guide includes a second shell defining a second cavity. The second guide is configured to extend proximate a lower plate of the TEM system, and is spaced a distance from the first guide to define a gap having a gap width. At least one of the first guide or second guide includes an access opening configured to provide access to at least one of the first cavity or the second cavity.

Abstract: A support frame is provided that includes an upper plate, a lower plate, side support members, an upper support structure, and a lower support structure. The upper plate defines a first inner surface and an opposed first outer surface. The lower plate defines a second inner surface and an opposed second outer surface. A TEM test space is defined between the first inner surface and the second inner surface. The side support members are disposed between the upper plate and the lower plate proximate a periphery of the test space. The upper support structure is coupled to and supports the upper plate. The upper support structure extends from the first outer surface of the upper plate. The lower support structure is coupled to and supports the lower plate. The lower support structure extends from the second outer surface of the lower plate.

Abstract: A mobile fixture includes a movable base, a support platform, an adaptor interface, at least one sensor, and a controller. The movable base is configured to travel over a floor. The support platform is articulable with respect to the base. The adaptor interface moves with the support platform, and is configured to mechanically interface with an attachment member. The at least one sensor is coupled to the adaptor interface and is configured to detect at least one of a force or movement resulting from an interaction between the adaptor interface and the attachment member. The controller is operably coupled to the movable base, support platform, and at least one sensor, and is configured to control movement of at least one of the movable base or support platform responsive to the at least one of the force or movement detected by the at least one sensor.

Abstract: A mobile fixture includes a movable base, a support platform, an adaptor interface, at least one sensor, and a controller. The movable base is configured to travel over a floor. The support platform is articulable with respect to the base. The adaptor interface moves with the support platform, and is configured to mechanically interface with an attachment member. The at least one sensor is coupled to the adaptor interface and is configured to detect at least one of a force or movement resulting from an interaction between the adaptor interface and the attachment member. The controller is operably coupled to the movable base, support platform, and at least one sensor, and is configured to control movement of at least one of the movable base or support platform responsive to the at least one of the force or movement detected by the at least one sensor.

Abstract: A mobile fixture includes a movable base, a support platform, an adaptor interface, at least one sensor, and a controller. The movable base is configured to travel over a floor. The support platform is articulable with respect to the base. The adaptor interface moves with the support platform, and is configured to mechanically interface with an attachment member. The at least one sensor is coupled to the adaptor interface and is configured to detect at least one of a force or movement resulting from an interaction between the adaptor interface and the attachment member. The controller is operably coupled to the movable base, support platform, and at least one sensor, and is configured to control movement of at least one of the movable base or support platform responsive to the at least one of the force or movement detected by the at least one sensor.