Abstract: Compositions that selectively bind to coronaviruses, including but not limited to SARS-COV-2 and methods of use thereof are provided. The disclosed antibodies and antigen-binding fragments were developed against SARS-CoV-2. The antibodies bind to the spike protein of coronaviruses. The disclosed antibodies are useful for diagnosing, detecting, preventing, and treating coronavirus infections.

Abstract: Disclosed are antimicrobial articles and surfaces, as well as methods of making such articles and surfaces.

Abstract: Disclosed herein are polymers comprising at least one alkyne functional group, at least one azide functional group, and a conformational bend outside of coplanarity of 30 or greater. Also disclosed herein are methods of making and using the same.

Abstract: Disclosed are antimicrobial articles and surfaces, as well as methods of making such articles and surfaces.

Abstract: Disclosed are antimicrobial articles and surfaces, as well as methods of making such articles and surfaces.

Abstract: The present invention provides polymer brush constructs, for example, surfaces decorated with hyaluronan polymers, and methods of making the same. The constructs are useful as functional materials for numerous applications, e.g., as lubricants, implant coatings, bandages and other uses.

Abstract: The present invention is directed to novel functionalized spirocentric compounds and polymers thereof that produce hyper-rigid cross-linked membranes.

Abstract: The present invention is directed to methods of fabricating novel cross-linked membranes and to cross-linked membranes produced by the disclosed methods. Specifically, methods of fabricating cross-linked membranes according to the present invention may comprise direct crosslinking, crosslinking by addition of a small molecule, interfacial crosslinking of free-standing film, and interfacial crosslinking on a solid support.

Abstract: Disclosed are antimicrobial articles and surfaces, as well as methods of making such articles and surfaces.

Abstract: A vaccine composition for treating and preventing infection by protozoans is disclosed. The vaccine composition comprises carbohydrates and/or peptides present on the surface of the protozoan, optionally bound to an immunogenic protein nanoparticle.

Abstract: Degradable materials including the reaction product of an oxanorbornadiene crosslinker or derivative thereof and a multivalent nucleophile-terminated compound, wherein the reaction product is a degradable elastic solid capable of entraining cargo. Degradable materials include a polymeric and hyperbranched crosslinked material made with oxanorbornadiene linkage that can be activated for cleavage at a predetermined rate by addition of a nucleophile. Methods of making and using degradable materials are included.

Abstract: Disclosed herein are degradable materials comprising the reaction product of an oxanorbornadiene crosslinker or derivative thereof and a multivalent nucleophile-terminated compound, wherein the reaction product is a degradable elastic solid capable of entraining cargo. Also disclosed herein are degradable materials comprising a polymeric and hyperbranched crosslinked material made with oxanorbornadiene linkage that can be activated for cleavage at a predetermined rate by addition of a nucleophile. Also disclosed herein are methods of making and using the same.

Abstract: Disclosed are polycationic polymers. The polycationic polymers can include a plurality of positively charged centers, each of which is formed by condensation of cyclic bis-electrophile (e.g., a 9-thia/aza/selenabicyclo[3.3.1]nonyl electrophile) with a nucleophile. The resulting polycationic polymers can efficiently bind nucleic acids. The polycations can also exhibit properties of cytotoxicity and DNA transfection with interesting structure-activity characteristics.

Abstract: Provided herein are immunogenic compositions comprising an immunogen with at least one complement component 5 (C5) epitope, wherein the immunogen is capable of generating autologous anti-C5 antibodies in a subject. In certain embodiments, such compositions are employed for treating and preventing complement component 5 (C5) related diseases. In certain embodiments, the immunogenic compositions comprise virus like particles and/or PADRE sequences, in addition to the C5 epitope(s).

Abstract: The present invention provides polymer brush constructs, for example, surfaces decorated with hyaluronan polymers, and methods of making the same. The constructs are useful as functional materials for numerous applications, e.g., as lubricants, implant coatings, bandages and other uses.

Abstract: The present invention is directed to novel functionalized spirocentric compounds and polymers thereof that produce hyper-rigid cross-linked membranes.

Abstract: The present disclosure relates to methods for using functional molecules and other structural carbon-based molecules with rigid backbones and kinked segments to alter the interactions between molecules, and consequently improve/modify the properties of materials. In particular, the disclosure provides methods for using functional molecules and other structural carbon-based molecules with rigid backbones and kinked segments as (1) precursors for carbon fiber, (2) “molecular agents” to separate and/or link ?-? stacked aromatic systems, 3) stabilizers in composite materials to achieve better blending of matrix with fiber reinforcement, and/or (4) one of the components in carbon fibers to achieve better mechanical properties.

Abstract: The present invention is directed to methods of fabricating novel cross-linked membranes and to cross-linked membranes produced by the disclosed methods. Specifically, methods of fabricating cross-linked membranes according to the present invention may comprise direct crosslinking, crosslinking by addition of a small molecule, interfacial crosslinking of free-standing film, and interfacial crosslinking on a solid support.

Abstract: In alternative embodiments, provided are selective agonists having a high affinity for the alpha7 nicotinic acetylcholine receptor (?7 nAChR), assays for selectivity of nicotinic receptor subtype and ligand-gated ion channel subtype based on receptor occupation and response, behavioral assessments for reversing cognitive impairment after scopolamine treatment, enhancing memory retention over time, pharmaceutical compositions and formulations and devices comprising them, and methods for making and using them, including characterizing and efficiently assaying them for receptor subtype selectivity. In alternative embodiments, provided are substituted anti 1,2,3-triazoles compounds with high affinity, and selective binding, for the alpha7 nicotine acetylcholine receptor (?7 nAChR), as exemplified by 5-(1-(2-(Piperidin-1-yl)ethyl)-1H-1,2,3-triazol-4-yl)-1H-indole (“IND1”), 5-((quinuclid-3-yl)-1H-1,2,3-triazol-4-yl)-1H-indole (“IND8”) and 3-(4-hydroxyphenyl-1,2,3-triazol-1-yl) quinuclidine (“QND8”).

Abstract: Disclosed are polycationic polymers. The polycationic polymers can include a plurality of positively charged centers, each of which is formed by condensation of cyclic bis-electrophile (e.g., a 9-thia/aza/selenabicyclo[3.3.1]nonyl electrophile) with a nucleophile. The resulting polycationic polymers can efficiently bind nucleic acids. The polycations can also exhibit properties of cytotoxicity and DNA transfection with interesting structure-activity characteristics.