Abstract: A method, a computer system, and a computer program product for a shiftleft topology construction is provided. Embodiments of the present invention may include collecting datasets. Embodiments of the present invention may include extracting topological entities from the datasets. Embodiments of the present invention may include correlating a plurality of data from the topological entities. Embodiments of the present invention may include mapping the topological entities. Embodiments of the present invention may include marking entry points for a plurality of subgraphs of the topological entities. Embodiments of the present invention may include constructing a topology graph.

Abstract: Methods of producing an optical surface atop an exterior of a substrate that includes smoothing the exterior using an ALD process to sequentially deposit ALD layers to produce one or more ALD films that fill spaces between spaced-apart asperities existing on the exterior, and thereafter depositing a reflective material on the smoothed exterior of the substrate to produce the optical surface. The smoothing resulting from depositing the ALD film on the exterior of the substrate causes the grain size of the reflective material to be reduced in comparison to the grain size that would exists without having deposited the ALD film on the exterior of the substrate. The smoothing is sufficient to cause a reduction in grain size that results in a reduction in plasmon absorption in the optical surface in comparison to the plasmon absorption that would otherwise exist without having reduced the grain size of the reflective material.

Abstract: A system and associated method for manipulating tissues and anatomical or other structures in medical applications for the purpose of treating diseases or disorders or other purposes. In one aspect, the system includes an expandable structure for enhancing engagement with median lobe prostate tissue.

Abstract: Water-in-oil sunscreen emulsion compositions including an aqueous phase emulsified within an external fatty phase are provided. The external fatty phase includes at least one silicone fatty compound and at least about 10% by weight of organic UV filters with respect to the entire sunscreen composition. The compositions include an emulsifying silicone elastomer and a non-elastomeric silicone surfactant. The compositions further include swellable clay and pigment.

Abstract: Embodiments provide an adjustable cage template for determining a cage for use in a spinal surgery. The adjustable cage template may include top and bottom cage template, control supports. A configuration of the cage template may be modified and sensors may measure forces applied to the cage template during the modification of the cage template configuration. Modifications to the cage template include rotation of the top cage template relative to the bottom cage template, vertical translation of the top cage template relative to the bottom cage template, or both rotation and vertical translation of the top and bottom cage templates. Information associated with measurements from the sensors may be output to determine whether a current configuration of the cage template is optimal and a final cage template may be selected for the spinal surgery based at least in part on the output information.

Abstract: A system and associated method for manipulating tissues and anatomical or other structures in medical applications for the purpose of treating diseases or disorders or other purposes. In one aspect, the system includes an expandable structure for enhancing engagement with median lobe prostate tissue.

Abstract: A system for configuring and providing cellular connectivity for a vehicle includes a vehicle communication system and a vehicle controller in electrical communication with the vehicle communication system. The vehicle controller is programmed to establish a connection between the vehicle communication system and a mobile device. The vehicle controller is further programmed to retrieve a cellular connectivity configuration profile from at least one remote server using an internet connection of the mobile device. The vehicle controller is further programmed to configure the vehicle communication system to connect to a cellular network using the cellular connectivity configuration profile.

Abstract: Embodiments provide an adjustable cage template for determining a cage for use in a spinal surgery. The adjustable cage template may include top and bottom cage template, control supports. A configuration of the cage template may be modified and sensors may measure forces applied to the cage template during the modification of the cage template configuration. Modifications to the cage template include rotation of the top cage template relative to the bottom cage template, vertical translation of the top cage template relative to the bottom cage template, or both rotation and vertical translation of the top and bottom cage templates. Information associated with measurements from the sensors may be output to determine whether a current configuration of the cage template is optimal and a final cage template may be selected for the spinal surgery based at least in part on the output information.

Abstract: Presented are intelligent vehicle communications systems for cellular link monitoring and failure detection, methods for making/using such systems, and vehicles equipped with such systems. A method for operating a wireless-enabled vehicle component of a motor vehicle includes a cellular communications device of the vehicle component detecting an uplink (or downlink) network data packet transmitted by (or to) the vehicle. An electronic vehicle controller then establishes an observation period as a function of the time at which the network data packet was transmitted. The opposite downlink (or uplink) of the wireless-enabled vehicle component is monitored to determine if a downlink (or uplink) network data packet is received within the observation period, thereby indicating detection of a cellular link failure.

Abstract: Described herein is an unbiased method of identifying tumor rejection mediating neoepitopes (TRMNs). Putative neoepitopes from a cancer cell exome sequence from a cancer patient are putative neoepitopes are unbiased by MHC binding and/or CD8T* reactivity. By plotting the putative neoepitope IC50s on one axis, and the non-mutated amino acid sequence IC50s on a perpendicular axis to provide a bivariate scatter plot, novel TRMNs are identified TRMNs the neoepitopes in the bivariate scatter plot which are in the space greater than 501 nM on the x-axis and greater than 501 nM on the y-axis. Peptides and nucleic acids for expressing peptides including the TRMNs are also described.

Abstract: Systems, methods, and computer-readable media are disclosed for processing input data to determine an entity such as a product, service, user profile, etc. referenced in or otherwise relevant to a semantic context of the input data. Information related to the entity may be provided as an information package (e.g., a card) that is shareable as part of an electronic message. The card may include a representation of a network resource identifier that identifies a network resource, a network location of the network resource, and an access mechanism for accessing a representation (e.g. a product detail page) of the network resource. The network resource identifier may include one or more tags or tokens that identify an electronic messaging application provider and/or a user such as a sender or recipient of an electronic message that includes the card so as to enable compensating the provider and/or the user for a purchase of a product or service to which the card relates.

Abstract: Methods and pharmaceutical compositions for delivering a therapeutic agent, treating a neovascularization disorder, and treating an ocular infection include make use of a compound that includes an elastin-like polypeptide (ELP) coupled to a therapeutic agent, wherein the ELP comprises at least one repeat of the amino acid sequence VPGXG (SEQ ID NO: 1), and where the composition is suitable for ocular administration.

Abstract: A rotary cutting tool includes a shank portion, a cutting portion, and a cutting tip. The cutting portion includes a plurality of blades and a plurality of flutes. Each blade includes a leading face, a trailing face, and a land surface extending between the leading face and the trailing face. The cutting end includes an end cutting edge having a first end face cutting edge portion formed with a positive, neutral or negative radial angle, a positive dish angle and a negative axial rake angle, and second end face cutting edge portion formed with a highly positive radial angle, a positive dish angle and a negative axial rake angle. The highly positive radial angle of the second end face cutting edge portion enables the rotary cutting tool to perform a ramp operation at very large ramp angles of between about 15-45 degrees.

Abstract: Systems, methods, and computer-readable media are disclosed for processing input data to determine an entity such as a product, service, user profile, etc. referenced in or otherwise relevant to a semantic context of the input data. Information related to the entity may be provided as an information package (e.g., a card) that is shareable as part of an electronic message. The card may include a representation of a network resource identifier that identifies a network resource, a network location of the network resource, and an access mechanism for accessing a representation (e.g. a product detail page) of the network resource. The network resource identifier may include one or more tags or tokens that identify an electronic messaging application provider and/or a user such as a sender or recipient of an electronic message that includes the card so as to enable compensating the provider and/or the user for a purchase of a product or service to which the card relates.

Abstract: A system and associated method for manipulating tissues and anatomical or other structures in medical applications for the purpose of treating diseases or disorders or other purposes. In one aspect, the system includes an expandable structure for enhancing engagement with median lobe prostate tissue.

Abstract: Presented are intelligent vehicle communications systems for cellular link monitoring and failure detection, methods for making/using such systems, and vehicles equipped with such systems. A method for operating a wireless-enabled vehicle component of a motor vehicle includes a cellular communications device of the vehicle component detecting an uplink (or downlink) network data packet transmitted by (or to) the vehicle. An electronic vehicle controller then establishes an observation period as a function of the time at which the network data packet was transmitted. The opposite downlink (or uplink) of the wireless-enabled vehicle component is monitored to determine if a downlink (or uplink) network data packet is received within the observation period, thereby indicating detection of a cellular link failure.

Abstract: A system and associated method for manipulating tissues and anatomical or other structures in medical applications for the purpose of treating diseases or disorders or other purposes. In one aspect, the system includes an expandable structure for enhancing engagement with median lobe prostate tissue.

Abstract: A rotary cutting tool includes a shank portion, a cutting portion, and a cutting tip. The cutting portion includes a plurality of blades and a plurality of flutes. Each blade includes a leading face, a trailing face, and a land surface extending between the leading face and the trailing face. The cutting end includes an end cutting edge having a first end face cutting edge portion formed with a positive, neutral or negative radial angle, a positive dish angle and a negative axial rake angle, and second end face cutting edge portion formed with a highly positive radial angle, a positive dish angle and a negative axial rake angle. The highly positive radial angle of the second end face cutting edge portion enables the rotary cutting tool to perform a ramp operation at very large ramp angles of between about 15-45 degrees.

Abstract: A first service's exhibition of a first symptom while executing a set of transactions is detected. A graph is constructed representing data flow between a set of services including the first service. By traversing the graph, a set of candidate services is constructed, a candidate service in the set of candidate services comprising a service exhibiting the first symptom, the set of candidate services including the first service. A probability of a first cause is evaluated, for the candidate service. At a problem service in the set of candidate services, a problem cause is ameliorated, the problem service identified using the set of candidate services and the probability of the first cause, the problem cause causing the first symptom.

Abstract: The present invention relates to the unexpected discovery of novel methods of preparing nanodevices and/or microdevices with predetermined patterns. In one aspect, the methods of the invention allow for engineering structures and films with continuous thickness equal to or less than 50 nm.