Abstract: Curved ion manipulation devices can provide relatively greater ion pathway lengths over conventional devices. Ions can be directed through one or more pairs of opposing curved surfaces of a curved ion manipulation structure. Each pair of opposing curved surfaces can be spaced apart radially relative to a common longitudinal axis of the ion manipulation structure to define a radial gap. Each pair of opposing curved surfaces can include a first electrode arrangement and a second electrode arrangement opposed to the first electrode arrangement. The first and second electrode arrangements can define an ion pathway and are configured to direct ions along the ion pathway and circumferentially through the radial gaps of the ion manipulation structure.

Abstract: Methods include directing a group of ions through a separation region of an ion manipulation apparatus, separating the group of ions in the separation region based on ion mobility, selecting a subset of the group of ions based on a dependence between ion mobility and ion arrival time of the separated ions at a deposition switch of the ion manipulation apparatus, and depositing the selected subset of ions on a substrate. Related systems and ion manipulation apparatus are disclosed. Also disclosed are methods and system that provide concurrent ion accumulation and ion separation in coupled and switchable electrode regions using traveling wave electric fields.

Abstract: The present invention is directed to a pharmaceutical product which includes a liquid formulation comprising levothyroxine or a pharmaceutically acceptable salt thereof. The formulation of the present invention includes a cyclodextrin, water, and an amine, and has a pH above the buffering range of the amine. The liquid formulation of the invention is stable and ready-to-use.

Abstract: Apparatus and methods are disclosed to improve performance of ion mobility separation. Deleterious bend effects are counteracted by adjusting phase shifts between adjoining traveling wave sections at bends; superior trajectories and performance are achieved. Improvements are also achieved by arranging serpentine paths primarily along a lengthwise direction of a substrate, thereby reducing the number of bends. An ion mobility spectrometers is coupled to a mass spectrometer, and intermittent traveling waves improve sample utilization or reduce total time required for combined ion analysis with both modalities.

Abstract: Methods, systems and devices are disclosed that provide, among other benefits, an adequate and effective pain management that can be implemented as part of surgical planning, pain management, and other applications. An example methodology for reducing post-operative pain of a subject includes administering, daily, for a first number of days before a surgery on the subject and according to a first pre-arranged schedule of administrations, light with one or more wavelengths in the range between approximately 515 nm and approximately 535 nm to the subject. The method further includes administering, daily, for a second number of days following the surgery and according to a second pre-arranged schedule of administrations, light with one or more wavelengths in the range between approximately 515 nm and approximately 535 nm. The light is administered for a time period during each day of the light administration.

Abstract: Systems and methods are presented for mitigating cyber threats. Cybersecurity-related data are stored in a semantic cybersecurity database. A user interface converts a user input to a command utterance. A command node that corresponds to the command utterance is identified in the cybersecurity database. The command node is resolved to one or more action nodes that are connected to the command node, and each action node is resolved to one or more parameter nodes that are connected to the action node. The command node has a command that implements actions indicated in the action nodes. Each action can have one or more required parameters indicated in the parameter nodes. The values of the required parameters are obtained from the command utterance, prompted from the user, or obtained from the cybersecurity database. Actions with their parameter values are executed to mitigate a cyber threat in accordance with the user input.

Abstract: Curved ion manipulation devices can provide relatively greater ion pathway lengths over conventional devices. Ions can be directed through one or more pairs of opposing curved surfaces of a curved ion manipulation structure. Each pair of opposing curved surfaces can be spaced apart radially relative to a common longitudinal axis of the ion manipulation structure to define a radial gap. Each pair of opposing curved surfaces can include a first electrode arrangement and a second electrode arrangement opposed to the first electrode arrangement. The first and second electrode arrangements can define an ion pathway and are configured to direct ions along the ion pathway and circumferentially through the radial gaps of the ion manipulation structure.

Abstract: Methods and apparatuses for ion manipulations, including ion trapping, transfer, and mobility separations, using traveling waves (TW) formed by continuous alternating current (AC) are disclosed. An apparatus for ion manipulation includes a surface to which are coupled a first plurality of continuous electrodes and a second plurality of segmented electrodes. The second plurality of segmented electrodes is arranged in longitudinal sets between or adjacent to the first plurality of electrodes. An RF voltage applied to adjacent electrodes of the first plurality of electrodes is phase shifted by approximately 180° to confine ions within the apparatus. An AC voltage waveform applied to adjacent electrodes within a longitudinal set of the second plurality of segmented electrodes is phase shifted on the adjacent electrodes by 1°-359° to move ions longitudinally through the apparatus for separation.

Abstract: The invention provides a demulsifier compound, formulations comprising the demulsifier compound, and methods for preparing the demulsifier compound.

Abstract: An apparatus includes multiple levels of ion transport channels, with successive levels coupled by elevator channels. Efficient three dimensional packing provides long path lengths in practical volumes for ion mobility separation with high resolving power. Disclosed elevator configurations provide efficient routing of ion transport channels across levels with low ion loss, enabling ion mobility separation over 100 levels or more. Elevator configurations include (i) opposed traveling waves meeting at an elevator entrance, (ii) external elevator with a wrap-around electrode bank, (iii) external elevator with electrode banks on parallel extension plates, or (iv) elevator operating in surfing mode, in various combinations. Manufacture is aided by printed wiring boards, with interchangeable boards. Assembly with motherboard, spacer block(s), and alignment pins provides efficient distribution of electrode excitations and accurate reproducible positioning.

Abstract: Methods and apparatuses for ion manipulations, including ion trapping, transfer, and mobility separations, using traveling waves (TW) formed by continuous alternating current (AC) are disclosed. An apparatus for ion manipulation includes a surface to which are coupled a first plurality of continuous electrodes and a second plurality of segmented electrodes. The second plurality of segmented electrodes is arranged in longitudinal sets between or adjacent to the first plurality of electrodes. An RF voltage applied to adjacent electrodes of the first plurality of electrodes is phase shifted by approximately 180° to confine ions within the apparatus. An AC voltage waveform applied to adjacent electrodes within a longitudinal set of the second plurality of segmented electrodes is phase shifted on the adjacent electrodes by 1°-359° to move ions longitudinally through the apparatus for separation.

Abstract: Methods, systems, and devices for wireless communications are described. Communication devices may perform secret key generation using a set of line-of-sight (LOS) communication modes to secure a physical channel. For example, a first device and a second device may communicate a set of reference signals over the physical channel using a set of LOS communication modes. The first device and the second device may generate a secret key based on the set of LOS communication modes, for example, by using information associated with the set of LOS communication modes to compute the secret key using a key derivation function that outputs the secret key. The first device and the second device may secure the physical channel by encrypting signaling between the first device and the second device with the secret key and communicating the signaling over the physical channel using LOS communications.

Abstract: Methods, systems, and devices for wireless communication are described to estimate interference for concurrent uplink and downlink communications based on an indication of one or more one or more characteristics of an interfering uplink signal communicated between a base station and a second user equipment (UE). The base station or the second UE may transmit, to a first UE, an indication of one or more characteristics of an uplink signal, such as a baseband of the uplink signal or one or more parameters of the uplink signal. The first UE may use the characteristic(s) of the uplink signal to estimate the baseband of the uplink signal and cancel interference associated with the uplink signal. For example, the first UE may use the baseband signal to estimate the interference and may subtract the estimated interference from a downlink signal received at the first UE.

Abstract: Devices and systems for treating based on light therapy are disclosed. One example device includes an eyewear configured for placement in front of an eye to allow light to reach the eye, and one or more filters having transmission spectra within a range that approximately spans 450 to 570 nm associated with blue or green light. The one or more filters is configured to block light spectra outside of said range and to allow the blue or green light to reach the eye for administering light therapy to a subject exhibiting pain.

Abstract: Apparatus include a plurality of electrode arrangements spaced apart from each other opposite an ion propagation axis and defining an ion transfer channel that extends along the ion propagation axis that tapers between an input end that is situated to receive ions and an output end that is situated to couple the received ions to an input end of an ion guide. Methods include positioning a plurality of electrode arrangements at oblique angles opposite an ion propagation axis so as to form a ion transfer channel that tapers between an input end and an output end, and coupling the output end of the ion transfer channel to an input end of an ion optical element so as to direct ions in the ion transfer channel into the ion optical element. Related systems are also disclosed.

Abstract: A passenger assistant system includes an artificial intelligence processing unit, a sensor interface, a flight crew interface, a passenger interface, and at least one end effector. The sensor interface couples the artificial intelligence processing unit with at least one sensor configured to provide environmental information regarding a cabin of an aircraft. The flight crew interface couples the artificial intelligence processing unit with at least one flight crew input. The passenger interface couples the artificial intelligence processing unit with at least one passenger input. The at least one end effector is coupled to the artificial intelligence processing unit. The artificial intelligence processing unit is configured to direct the at least one end effector to perform at least one task responsive to information acquired from one or more of the sensor interface, flight crew interface, or passenger interface.

Abstract: Methods, systems, and devices for wireless communications are described. In a wireless communications system, a user equipment (UE) may receive control signaling indicating a first semi-static configuration for transmitting uplink signaling and a second semi-static configuration for receiving downlink signaling. In some cases, the UE may operate using half-duplex communications and may monitor for a transmission direction conflict between the first semi-static configuration and the second semi-static configuration during a transmission time interval. The UE may communicate, according to a priority rule, one of an uplink signal in accordance with the first semi-static configuration or a downlink signal in accordance with the second semi-static configuration during the transmission time interval based on the monitoring. Additionally, or alternatively, the UE may drop one of the uplink signal or downlink signal according to the priority rule.

Abstract: Embodiments of a safety alert device and associated methods are disclosed. In one embodiment, the safety alert device includes a processing element and an image sensor in operative communication with the processing element. The processing element is configured to receive image data of a region of interest. The processing element determine a presence of a moving object in the region of interest based on the image data. The processing element is configured to identify a presence of a person in the region of interest based on the image data. The processing element determines a likelihood of a collision between the moving object and the person, and generates, based on the likelihood being above a threshold, an alert adapted to warn the person of the likelihood of the collision.

Abstract: Thioctamer, a nanoconjugate of glatiramer acetate (GA) and thioctic acid (TA), e.g. in the form of nanospheres, is provided as are compositions comprising thioctamer and methods of using the same for wound healing. Application of thioctamer to a wound accelerates wound healing, compared to control wounds that are not treated with the copolymer.

Abstract: Apparatus comprise an electrode arrangement comprising a plurality of electrodes defining a volume, an ion entrance, and an ion exit, and a voltage source coupled to the plurality of electrodes and configured to apply a nonlinear DC voltage sequence to the electrodes between the ion entrance and the ion exit that directs ions through the volume with the volume at a pressure of at least 1 Torr. Ions can be focused using nonlinear DC voltage sequences, including at atmospheric pressure. Related methods are also disclosed.