Abstract: A system for early detection and treatment of sepsis, comprising a fluid transfer device having an inlet and an outlet. The inlet is configured to receive a flow of bodily fluid. A flow-based assay device is configured to be coupled to the fluid transfer device. A portion of the flow-based assay device engages the outlet to allow a portion of a first volume of the bodily fluid to be transferred to the flow-based assay device. The flow-based assay device is configured to detect at least one sepsis-associated biomarker. Processing circuitry is configured to receive data from the flow-based assay device, apply a computational model to the received data, generate a sepsis probability score based on an output of the applied computational model, and when the sepsis probability score exceeds a sepsis-associated threshold, alert a care provider to initiate corresponding treatment.

Abstract: An apparatus and method for monitoring live-action gameplay interactions may be provided. A weapon device, body sensors, and a hub may be used to detect interactions, such as weapon strikes or casting of a spell. Interactions may be communicated to a game application on a mobile device for updating gameplay data.

Abstract: A system and method for interactive game support may be provided. A player may have a mobile device configured to run a game support application. The game support application may maintain game and player attributes and monitor interactions with game devices. In some embodiments, a command-control center server may be communicatively coupled with the at least one mobile device or game device so as to facilitate game management.

Abstract: An apparatus and method for monitoring live-action gameplay interactions may be provided. A weapon device, body sensors, and a hub may be used to detect interactions, such as weapon strikes or casting of a spell. Interactions may be communicated to a game application on a mobile device for updating gameplay data.

Abstract: A system and method for interactive game support may be provided. A player may have a mobile device configured to run a game support application. The game support application may maintain game and player attributes and monitor interactions with game devices. In some embodiments, a command-control center server may be communicatively coupled with the at least one mobile device or game device so as to facilitate game management.

Abstract: A method of fishing that employs a fishing loop as the terminal tackle article that holds bait and interoperates with fish attractants. The fishing loop opens a gap urged by pressure between a gradual bend top and a loop closing extension to receive bait and allow fish flesh to pass. The gap closes after pressure is released holding the bait or engaged fish. The fishing loop has an elongated lever eye for securing fishing line. The lever eye also serves to help the loop stay closed under pressure from swimming fish. The fishing loop can be shaped from a single section of wire or rod; or, the loop closing extension can be a separate flexible material when rigidity in the fish engaging portion is desired. The fishing loop can be used with natural or penetrable artificial bait.

Abstract: Mass spectrometry techniques for determining the status of sepsis in an individual are provided. A biomarker profile resolved from a biological sample, taken from the individual, using a mass spectrometry technique is compared to a reference biomarker profile. A single such comparison classifies the individual as belonging to or not belonging to a reference population. The individual's biomarker profile and the reference biomarker profile comprise a plurality of ions each having a mass-to-charge ratio of about 100 Daltons to about 1000 Daltons. The plurality of ions can be detected by electrospray ionization mass spectrometry in positive mode. The comparison uses a decision rule, such as a classification tree, that determines the status of sepsis in the individual without requiring knowledge of the identity of the biomarkers in the biomarker profile from the individual and without requiring knowledge of the identity of the biomarkers in the reference biomarker profile.

Abstract: The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished using a molecular diagnostics approach, involving comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population who develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated at the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms.

Abstract: Mass spectrometry techniques for determining the status of sepsis in an individual are provided. A biomarker profile resolved from a biological sample, taken from the individual, using a mass spectrometry technique is compared to a reference biomarker profile. A single such comparison classifies the individual as belonging to or not belonging to a reference population. The individual's biomarker profile and the reference biomarker profile comprise a plurality of ions each having a mass-to-charge ratio of about 100 Daltons to about 1000 Daltons. The plurality of ions can be detected by electrospray ionization mass spectrometry in positive mode. The comparison uses a decision rule, such as a classification tree, that determines the status of sepsis in the individual without requiring knowledge of the identity of the biomarkers in the biomarker profile from the individual and without requiring knowledge of the identity of the biomarkers in the reference biomarker profile.

Abstract: The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished by comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population that develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated from the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms of sepsis.

Abstract: Mass spectrometry techniques for determining the status of sepsis in an individual are provided. A biomarker profile resolved from a biological sample, taken from the individual, using a mass spectrometry technique is compared to a reference biomarker profile. A single such comparison classifies the individual as belonging to or not belonging to a reference population. The individual's biomarker profile and the reference biomarker profile comprise a plurality of ions each having a mass-to-charge ratio of about 100 Daltons to about 1000 Daltons. The plurality of ions can be detected by electrospray ionization mass spectrometry in positive mode. The comparison uses a decision rule, such as a classification tree, that determines the status of sepsis in the individual without requiring knowledge of the identity of the biomarkers in the biomarker profile from the individual and without requiring knowledge of the identity of the biomarkers in the reference biomarker profile.

Abstract: A method of reciprocally publishing and matching data files is disclosed. The method includes facilitating the creation of Category A and Category B data files having a respective sets of characteristics defined utilizing a common language architecture, associating enhancement objects with each data file, identifying characteristics in each data file which must be met by other data files, weighting characteristics in each data file differently from other characteristics in the same data file, enabling the selection of participation levels for each data file in marketspaces, and matching Category A data files participating in particular marketspaces to Category B data files participating in the same marketspaces using the common language architecture, the enhancement objects, the weights and the required characteristics.

Abstract: A method of reciprocally publishing and matching data files is disclosed. The method includes facilitating the creation of Category A and Category B data files having a respective sets of characteristics defined utilizing a common language architecture, associating enhancement objects with each data file, identifying characteristics in each data file which must be met by other data files, weighting characteristics in each data file differently from other characteristics in the same data file, enabling the selection of participation levels for each data file in marketspaces, and matching Category A data files participating in particular marketspaces to Category B data files participating in the same marketspaces using the common language architecture, the enhancement objects, the weights and the required characteristics.

Abstract: A method of reciprocally publishing and matching data files is disclosed. The method includes facilitating the creation of Category A and Category B data files having a respective sets of characteristics defined utilizing a common language architecture, associating enhancement objects with each data file, identifying characteristics in each data file which must be met by other data files, weighting characteristics in each data file differently from other characteristics in the same data file, enabling the selection of participation levels for each data file in marketspaces, and matching Category A data files participating in particular marketspaces to Category B data files participating in the same marketspaces using the common language architecture, the enhancement objects, the weights and the required characteristics.

Abstract: A method of reciprocally publishing and matching data files is disclosed. The method includes facilitating the creation of Category A and Category B data files having a respective sets of characteristics defined utilizing a common language architecture, associating enhancement objects with each data file, identifying characteristics in each data file which must be met by other data files, weighting characteristics in each data file differently from other characteristics in the same data file, enabling the selection of participation levels for each data file in marketspaces, and matching Category A data files participating in particular marketspaces to Category B data files participating in the same marketspaces using the common language architecture, the enhancement objects, the weights and the required characteristics.

Abstract: A method of reciprocally publishing and matching data files is disclosed. The method includes facilitating the creation of Category A and Category B data files having a respective sets of characteristics defined utilizing a common language architecture, associating enhancement objects with each data file, identifying characteristics in each data file which must be met by other data files, weighting characteristics in each data file differently from other characteristics in the same data file, enabling the selection of participation levels for each data file in marketspaces, and matching Category A data files participating in particular marketspaces to Category B data files participating in the same marketspaces using the common language architecture, the enhancement objects, the weights and the required characteristics.

Abstract: A method of reciprocally publishing and matching data files is disclosed. The method includes facilitating the creation of Category A and Category B data files having a respective sets of characteristics defined utilizing a common language architecture, associating enhancement objects with each data file, identifying characteristics in each data file which must be met by other data files, weighting characteristics in each data file differently from other characteristics in the same data file, enabling the selection of participation levels for each data file in marketspaces, and matching Category A data files participating in particular marketspaces to Category B data files participating in the same marketspaces using the common language architecture, the enhancement objects, the weights and the required characteristics.

Abstract: The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished by comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population who develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated at the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms.

Abstract: The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished using a molecular diagnostics approach, involving comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population who develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated at the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms.

Abstract: The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished using a molecular diagnostics approach, involving comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population that develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated at the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms of sepsis.