Patents by Inventor M. Josefina Coloma

M. Josefina Coloma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified immunoglobin molecules and methods for use thereof
    Patent number: 6284536
    Abstract: Disclosed are modified immunoglobulin (Ig) molecules, a method of producing modified Ig molecules, and methods for treatment and prevention of infectious diseases using modified Ig molecules. In one embodiment, the modified Ig molecule comprises a CH3 domain of an IgA molecule (&agr; CH3). The combination of an &agr; CH3 with other domains selected from one or more nonIgA Ig molecules provides an Ig molecule that has the capacity to bind J chain and/or secretory component (SC) together with features of a nonIgA molecule. In another embodiment, the modified Ig molecule comprises a CH1 and/or a CH2 domain of an IgA molecule. The combination of an &agr; CH1 and/or CH2 domain with other domains selected from one or more nonIgA Ig molecules provides an Ig molecule that has the capacity to form higher polymers (trimers, tetramers, pentamers, etc.) together with features of a nonIgA molecule. In one embodiment, the modified immunoglobulin molecule lacks one or more carbohydrate addition sites.
    Type: Grant
    Filed: April 20, 1999
    Date of Patent: September 4, 2001
    Assignee: The Regents of the University of California
    Inventors: Sherie L. Morrison, Koteswara R. Chintalacharuvu, Esther Mikyung Yoo, Kham M. Trinh, M. Josefina Coloma