Patents by Inventor M. Judah Folkman

M. Judah Folkman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6630448
    Abstract: Methods of inhibiting angiogenesis by administration of an isolated endostatin protein. Endostatin may be administered to individuals for treatment or repression of the growth of tumors, or administered to endothelial cells to inhibit their proliferation.
    Type: Grant
    Filed: September 16, 1998
    Date of Patent: October 7, 2003
    Assignee: The Children's Medical Center Corporation
    Inventors: Michael S. O'Reilly, M. Judah Folkman
  • Patent number: 6607724
    Abstract: The invention provides for methods of reducing or inhibiting angiogenesis, tumor growth and endothelial cell proliferation by the administration of compositions containing fragments, conformations, biological equivalent, or derivatives of antithrombin III. The invention also provides for pharmaceutical compositions comprising a fragment, conformation, biological equivalent, or derivative of antithrombin III and methods of identifying novel inhibitors of tumor growth, endothelial cell proliferation, and/or angiogenesis. The invention also relates to compositions and methods for altering angiogenesis in a mammal, as well as to methods of treatment for disorders associated with angiogenesis (e.g., cancer).
    Type: Grant
    Filed: October 8, 1999
    Date of Patent: August 19, 2003
    Assignee: Children's Hospital
    Inventors: Michael S. O'Reilly, M. Judah Folkman, Steven Pirie-Shepherd
  • Publication number: 20030114370
    Abstract: Endostatin compositions capable of inhibiting endothelial cell proliferation, inhibiting angiogenesis and causing tumor regression are described. Specifically, amino acid sequences of endostatin proteins and nucleic acid sequences coding for endostatin proteins are provided.
    Type: Application
    Filed: January 11, 2002
    Publication date: June 19, 2003
    Inventors: M. Judah Folkman, Michael S. O'Reilly
  • Publication number: 20030087393
    Abstract: An inhibitor of endothelial cell proliferation, capable of inhibiting angiogenesis and causing tumor regression, that is approximately 20 kDa and corresponds to a C-terminal fragment of collagen type XVIII, and methods of treating angiogenesis-related disease.
    Type: Application
    Filed: September 3, 2002
    Publication date: May 8, 2003
    Inventors: Michael S. O'Reilly, M. Judah Folkman
  • Patent number: 6544758
    Abstract: An inhibitor of endothelial cell proliferation, capable of inhibiting angiogenesis and causing tumor regression, that is approximately 20 kDa and corresponds to a C-terminal fragment of collagen type XVIII, and methods of treating angiogenesis-related disease.
    Type: Grant
    Filed: October 16, 1998
    Date of Patent: April 8, 2003
    Assignee: The Children's Medical Center Corporation
    Inventors: Michael S. O'Reilly, M. Judah Folkman
  • Publication number: 20030064926
    Abstract: Fragments of an endothelial cell proliferation inhibitor and method of use therefor are provided. The endothelial proliferation inhibitor is a protein derived from plasminogen, or more specifically is an angiostatin fragment. The angiostatin fragments generally correspond to kringle structures occurring within the endothelial cell proliferation inhibitor. The endothelial cell inhibiting activity of these fragments provides a means for inhibiting angiogenesis of tumors and for treating angiogenic-mediated disease.
    Type: Application
    Filed: April 22, 2002
    Publication date: April 3, 2003
    Inventors: M. Judah Folkman, Michael S. O'Reilly, Yihai Cao, Kim Lee Sim
  • Patent number: 6521439
    Abstract: Nucleic acid sequences encoding kringle region fragments of plasminogen. Ribonucleic and deoxyribonucleic acid sequences that encode for kringle region fragments are useful for gene therapy or recombinant expression for the treatment of angiogenesis-related diseases, specifically angiogenesis-dependent cancer.
    Type: Grant
    Filed: June 17, 1999
    Date of Patent: February 18, 2003
    Assignee: The Children's Medical Center Corporation
    Inventors: M. Judah Folkman, Michael S. O'Reilly, Yihai Cao
  • Publication number: 20020164717
    Abstract: Fragments of an endothelial cell proliferation inhibitor and method of use therefor are provided. The endothelial proliferation inhibitor is a protein derived from plasminogen, or more specifically is an angiostatin fragment. The angiostatin fragments generally correspond to kringle structures occurring within the endothelial cell proliferation inhibitor. The endothelial cell inhibiting activity of these fragments provides a means for inhibiting angiogenesis of tumors and for treating angiogenic-mediated disease.
    Type: Application
    Filed: June 17, 1999
    Publication date: November 7, 2002
    Inventors: M. JUDAH FOLKMAN, MICHAEL S. O'REILLY, YIHAI CAO
  • Publication number: 20020155987
    Abstract: An inhibitor of endothelial cell proliferation, capable of inhibiting angiogenesis and causing tumor regression, that is approximately 20 kDa and corresponds to a C-terminal fragment of collagen type XVIII, and methods of treating angiogenesis-related disease.
    Type: Application
    Filed: September 16, 1998
    Publication date: October 24, 2002
    Inventors: MICHAEL S. O'REILLY, M. JUDAH FOLKMAN
  • Publication number: 20020127595
    Abstract: An inhibitor of endothelial cell proliferation, capable of inhibiting angiogenesis and causing tumor regression, that is approximately 20 kDa and corresponds to a C-terminal fragment of collagen type XVIII, and methods of treating angiogenesis-related disease.
    Type: Application
    Filed: October 16, 1998
    Publication date: September 12, 2002
    Inventors: MICHAEL S. O'REILLY, M. JUDAH FOLKMAN
  • Publication number: 20020123458
    Abstract: An inhibitor of endothelial cell proliferation, capable of inhibiting angiogenesis and causing tumor regression, that is approximately 20 kDa and corresponds to a C-terminal fragment of collagen type XVIII, and methods of treating angiogenesis-related disease.
    Type: Application
    Filed: September 23, 1999
    Publication date: September 5, 2002
    Inventors: MICHAEL S. O'REILLY, M. JUDAH FOLKMAN
  • Publication number: 20020086352
    Abstract: An inhibitor of endothelial cell proliferation, capable of inhibiting angiogenesis and causing tumor regression, that is approximately 20 kDa and corresponds to a C-terminal fragment of collagen type XVIII, and methods of treating angiogenesis-related disease.
    Type: Application
    Filed: October 16, 1998
    Publication date: July 4, 2002
    Inventors: MICHAEL S. O'REILLY, M. JUDAH FOLKMAN
  • Publication number: 20020076413
    Abstract: The invention provides for methods of reducing or inhibiting angiogenesis, tumor growth and endothelial cell proliferation by the administration of compositions containing fragments, conformations, biological equivalent, or derivatives of antithrombin III. The invention also provides for pharmaceutical compositions comprising a fragment, conformation, biological equivalent, or derivative of antithrombin III and methods of identifying novel inhibitors of tumor growth, endothelial cell proliferation, and/or angiogenesis. The invention also relates to compositions and methods for altering angiogenesis in a mammal, as well as to methods of treatment for disorders associated with angiogenesis (e.g., cancer).
    Type: Application
    Filed: October 8, 1999
    Publication date: June 20, 2002
    Inventors: MICHAEL S. O'REILLY, M. JUDAH FOLKMAN, STEVEN PIRIE-SHEPHERD
  • Publication number: 20020037847
    Abstract: Fragments of an endothelial cell proliferation inhibitor and method of use therefor are provided. The endothelial proliferation inhibitor is a protein derived from plasminogen, or more specifically is an angiostatin fragment. The angiostatin fragments generally correspond to kringle structures occurring within the endothelial cell proliferation inhibitor. The endothelial cell inhibiting activity of these fragments provides a means for inhibiting angiogenesis of tumors and for treating angiogenic-mediated disease.
    Type: Application
    Filed: January 16, 2001
    Publication date: March 28, 2002
    Inventors: Michael S. O'Reilly, M. Judah Folkman
  • Patent number: 6346510
    Abstract: Endostatin compositions capable of inhibiting endothelial cell proliferation, inhibiting angiogenesis and causing tumor regression are described. Specifically, amino acid sequences of endostatin proteins and nucleic acid sequences coding for endostatin proteins are provided.
    Type: Grant
    Filed: May 20, 1999
    Date of Patent: February 12, 2002
    Assignee: The Children's Medical Center Corporation
    Inventors: Michael S. O'Reilly, M. Judah Folkman
  • Publication number: 20010029246
    Abstract: Fragments of an endothelial cell proliferation inhibitor and method of use therefor are provided. The endothelial proliferation inhibitor is a protein derived from plasminogen, or more specifically is an angiostatin fragment. The angiostatin fragments generally correspond to kringle structures occurring within the endothelial cell proliferation inhibitor. The endothelial cell inhibiting activity of these fragments provides a means for inhibiting angiogenesis of tumors and for treating angiogenic-mediated disease.
    Type: Application
    Filed: February 16, 2001
    Publication date: October 11, 2001
    Inventors: Michael S. O'Reilly, M. Judah Folkman, Yihai Cao
  • Publication number: 20010016644
    Abstract: The present invention comprises an endothelial inhibitor and method of use therefor. The endothelial cell proliferation inhibitor is a protein having a molecular weight of approximately 14 kD and having a N-terminal sequence of GPVGAGEPKCPLMVKVLDAV, that has the ability to inhibit endothelial cell proliferation in in vitro assays.
    Type: Application
    Filed: December 29, 2000
    Publication date: August 23, 2001
    Inventors: Yihai Cao, Michael S. O'Reilly, M. Judah Folkman
  • Patent number: 6174861
    Abstract: The present invention provides methods of inhibiting angiogenesis by increasing the concentration of endostatin protein or endostatin protein fragments in vivo. The methods of the present invention may be used for the treatment of angiogenesis-dependent diseases such as cancer.
    Type: Grant
    Filed: July 7, 1999
    Date of Patent: January 16, 2001
    Assignee: The Children's Medical Center Corporation
    Inventors: Michael S. O'Reilly, M. Judah Folkman
  • Patent number: 6024688
    Abstract: Fragments of an endothelial cell proliferation inhibitor and method of use therefor are provided. The endothelial proliferation inhibitor is a protein derived from plasminogen, or more specifically is an angiostatin fragment. The angiostatin fragments generally correspond to kringle structures occurring within the endothelial cell proliferation inhibitor. The endothelial cell inhibiting activity of these fragments provides a means for inhibiting angiogenesis of tumors and for treating angiogenic-mediated disease.
    Type: Grant
    Filed: April 24, 1998
    Date of Patent: February 15, 2000
    Assignee: The Children's Medical Center Corporation
    Inventors: M. Judah Folkman, Michael S. O'Reilly, Yihai Cao
  • Patent number: 5945403
    Abstract: Fragments of an endothelial cell proliferation inhibitor and method of use therefor are provided. The endothelial proliferation inhibitor is a protein derived from plasminogen, or more specifically is an angiostatin fragment. The angiostatin fragments generally correspond to kringle structures occurring within the endothelial cell proliferation inhibitor. The endothelial cell inhibiting activity of these fragments provides a means for inhibiting angiogenesis of tumors and for treating angiogenic-mediated disease.
    Type: Grant
    Filed: May 30, 1997
    Date of Patent: August 31, 1999
    Assignee: The Children's Medical Center Corporation
    Inventors: M. Judah Folkman, Michael S. O'Reilly