Abstract: Disclosed herein are mutant Plasmodium-species parasites that are genetically attenuated (GAP). They retain the ability to infect a host and invade host hepatocytes but subsequently their development is completely arrested within the liver stage of Plasmodium development and the parasites do not reach the blood stage of development. Vaccines and pharmaceutical compositions comprising genetically attenuated Plasmodium sporozoites as well as methods of using the same are likewise provided.

Abstract: HslVU is the proteasome-related system composed of HslV peptidase and HslU chaperone. It is involved in intracellular proteolysis. The presence of HslVU homologs in pathogenic microbes and its absence in human makes it an antimicrobial drug target. The functional HslVU complex forms when HslV dodecamer is flanked at both ends by HslU hexamers. In the HslVU complex, intercalation of C-termini residues of HslU subunits into the clefts between adjacent HslV subunits results in allosteric activation of HslV. We identified small molecules capable of activating HslV peptidase in the absence of its natural activator HslU. Quinazoline and chromone derivatives were suggested by ligand docking to bind at the HslU C-termini intercalation pockets in the HslV. This was confirmed by HslV activation assays with these compounds that gave ED50 in sub-micromolar range. The results showed that small, extracellular non-peptidic molecules can activate the HslV peptidase which in turn would initiate intracellular proteolysis.

Abstract: A cable bypass assembly is disclosed for use in providing a high speed transmission line for connecting a board mounted connector of an electronic device to a chip on the device board. The bypass cable assembly has a structure that permits it, where it is terminated to the board mounted connector and the chip member, or closely proximate thereto to replicate closely the geometry of the cable. The connector terminals are arranged in alignment with the cable signal conductors and shield extensions are provided so that shielding can be provided up to and over the termination between the cable signal conductors and the board connector terminal tails. Likewise, a similar termination structure is provided at the opposite end of the cable where a pair of terminals are supported by a second connector body and enclosed in a shield collar. The shield collar has an extension that engages the second end of the cable.

Abstract: ?-Chymotrypsin inhibitors of thiourea class are reported that could be potent inhibitors of proteases, elastases, proteasomes, NS3 and NS4 serine protease of hepatitis C virus, dengue virus, etc. Compounds 1-22, which are belong to thiourea class, showed good inhibition. Their kinetics study and cytotoxicity profiles showed all type of inhibition except uncompetitive-type inhibition and no cytotoxicity except few compounds. Competitive type of inhibitors could inhibit other ?-chymotrypsin-like serine proteases, which are therapeutics target.

Abstract: Systems and computer program products for relating facts stored in healthcare databases are provided. At least two fact tables stored in a healthcare database including data meeting a criteria of interest are located. An identification key is assigned to the at least two fact tables including the located data meeting the criteria of interest. The identification key provides access to a dimension table including a list of subjects associated with the at least two fact tables including the located data meeting the criteria of interest so as to allow future identification of the subjects meeting the criteria of interest.

Abstract: Methods and systems for routing video in conferencing are disclosed. A device receives one or more data streams from a media source, where each data stream associated with a data stream identifier. A media source identifier is assigned to each data stream from the media source. The data stream identifiers are mapped to the media source identifiers. At least one of the data streams may be modified by replacing an associated data stream identifier with the media source identifier. The modified data streams are provided to a destination device. A request is received from a destination device for data streams associated with a media source identifier. One or more data stream identifiers are associated with the requested media source identifier. The one or more data streams may be associated with Application sharing/Desktop Sharing, a video quality, a video resolution, a video frame rate, or an audio quality.

Abstract: I/O logic can be separated into critical and non-critical portions, with the non-critical portions being powered down during processor idle. The I/O logic is separated into gate logic and ungated logic, where the ungated logic continues to be powered during a processor deep sleep state, and the gated logic is powered off during the deep sleep state. A power control unit can trigger the shutting down of the I/O logic.

Abstract: This invention provides a series of new oxindole derivatives 1-21, evaluated for their antiglycation potential by using in vitro BSA-MG glycation model. These derivatives showed a varying degree of antiglycation activity with IC50 values ranging between 150-856 ?M. Compound 14 (IC50=150.4±2.5 ?M) was found to be the most potent among all derivatives, even better than the standard inhibitor i.e. rutin (IC50=294.5±1.50 followed by compounds 13 and 8 with IC50 value of 194.40±2.5 and 211.41±4.1 ?M, respectively.

Abstract: At least one attribute type associated with an individual in a first record of a first database and one or more similar attribute types in record(s) of other second database(s) are located. The attribute types compared. Based on the comparison, a first weighted score for the first record and another weighted score for each other records are computed. The weighted score indicates a likelihood the particular attribute type is associated with a same individual as other attribute type(s) located in other record(s) and further accounts for a time delta between measurements of the attribute types. Confidence score outputs for the records are also computed. The confidence score output of a record is based on all weighted scores of that record and indicates a likelihood that record is associated with the same individual. At least one database is updated based on at least one of the confidence score outputs.

Abstract: In one aspect, methods of detecting tumor cells are described herein. In some embodiments, a method of detecting tumor cells comprises providing a device, the device comprising a substrate surface and a plurality of first aptamer probes attached to the substrate surface. The method further comprises contacting a plurality of cells with the plurality of first aptamer probes attached to the substrate surface; adhering one or more of the plurality of cells to the substrate surface; and measuring a non-uniformity parameter, a Hausdorff distance, a change in the number of pseudopods, and/or a shape of at least one adhered cell. In some cases, the method further comprises using the non-uniformity parameter, Hausdorff distance, change in the number of pseudopods, and/or shape of the adhered cell to identify the adhered cell as a tumor cell or a non-tumor cell.

Abstract: The invention discloses creatine derivatives that are represented by Formula (I), Formula (II), and Formula (III); wherein Z is a functional group; Y is a mitochondrial targeting agent, a cationic ammonium group, or a polypeptide containing at least one positively charged amino acid residue; each R1 is independently hydrogen, alkyl, or a phosphate group; R2 a linker; R3 is a spacer group; R4 is hydrogen, alkyl, aryl, or heterocyclic; or R4 and R1, or R4 and R3, together with the nitrogen atoms to which they are attached form a heterocyclic ring, and W is hydrogen or alkyl.

Abstract: The invention feature series of benzothiazole derivatives as potent immunosuppressive and antiinflammatory agents. Eight compounds 2, 4, 5, 8, 9, 10, 12, and 18 showed potent inhibitory activity on PHA-activated T-cell proliferation. Compounds 2, 4, 8, and 18 were found to have a potent inhibitory activity with IC50 values ranging <1.0-2.9 ?g/mL against IL-2. Studies on innate immune response revealed that compounds 2, 8, 9, and 10 have significant suppressive effect on ROS production with an IC50 values 1.9, <1, 3.7 and 1.1 ?g/mL, respectively. The LPS-induced nitrites in J774 macrophages cell line was inhibited by 4, 8, 9, and 18 at a concentration of 25 ?g/mL (56-91%). In addition compounds 5, 8, 12, and 18 showed potent suppression on interleukin 4 (IL-4), particularly 9 (IC50<1 ?g/mL). No cytotoxicity was found except for compound 9 and 18 (11.4 and 10.4 ?g/mL IC50), respectively.

Abstract: The present application provides, among other things, compounds and methods for metathesis reactions. In some embodiments, provided compounds promote highly efficient and highly Z-selective metathesis. In some embodiments, provided compounds and methods are particularly useful for producing allyl alcohols. In some embodiments, provided compounds have the structure of formula I. In some embodiments, provided compounds comprise ruthenium, and a ligand bonded to ruthenium through a sulfur atom.

Abstract: HslVU is the proteasome-related system composed of HslV peptidase and HslU chaperone. It is involved in intracellular proteolysis. The presence of HslVU homologs in pathogenic microbes and its absence in human makes it an antimicrobial drug target. The functional HslVU complex forms when HslV dodecamer is flanked at both ends by HslU hexamers. In the HslVU complex, intercalation of C-termini residues of HslU subunits into the clefts between adjacent HslV subunits results in allosteric activation of HslV. We identified small molecules capable of activating HslV peptidase in the absence of its natural activator HslU. Quinazoline and chromone derivatives were suggested by ligand docking to bind at the HslU C-termini intercalation pockets in the HslV. This was confirmed by HslV activation assays with these compounds that gave ED50 in sub-micromolar range. The results showed that small, extracellular non-peptidic molecules can activate the HslV peptidase which in turn would initiate intracellular proteolysis.

Abstract: Methods, systems and computer program products for associating healthcare records in healthcare databases with an individual are provided. One or more attribute types are located in first and second records. The one or more attribute types being associated with the individual. A weighted score is determined for the located at least one attribute type based on a comparison of the located at least one attribute type in the first record and the located at least one attribute type in the second record. The weighted score indicates a likelihood that the located at least one attribute type in the first and second records are both associated with the individual. A confidence is provided and is associated with the first and second records based on the weighted score. The confidence score indicates a likelihood that both the first and second records are associated with the individual.

Abstract: A system and method to enforce read-write partitioning in an N-way, set associative cache may limit a number of ways allocated for storing modified data in a set to a value W and limit a number of ways holding read data to a value R. The cache may be configured where N=R+W. Furthermore, a number of ways storing prefetched read data may be limited to RP, while a number of ways storing prefetched modified data may be limited to WP. The values for W, R, WP, and/or RP may be determined using a prediction method to estimate cache miss rates for different values for W, R, WP, and/or RP and selecting values corresponding to a desired cache miss rate, and so allowing for selective application of the read-write partitioning.

Abstract: Surprising antiviral activity of 3-amino-2-(4-nitrophenyl)-4-(3H)-quinazolinone (Compound 1) was reported in the treatment or prevention of viral infections, particularly in combination with other antiviral agents such as interferon and/or ribavarin.

Abstract: A high speed voltage mode sensing is provided for a digital multibit non-volatile memory integrated system. An embodiment has a local source follower stage followed by a high speed common source stage. Another embodiment has a local source follower stage followed by a high speed source follower stage. Another embodiment has a common source stage followed by a source follower. An auto zeroing scheme is used. A capacitor sensing scheme is used. Multilevel parallel operation is described.

Abstract: Methods and systems for routing video in conferencing are disclosed. A device receives one or more data streams from a media source, where each data stream associated with a data stream identifier. A media source identifier is assigned to each data stream from the media source. The data stream identifiers are mapped to the media source identifiers. At least one of the data streams may be modified by replacing an associated data stream identifier with the media source identifier. The modified data streams are provided to a destination device. A request is received from a destination device for data streams associated with a media source identifier. One or more data stream identifiers are associated with the requested media source identifier. The one or more data streams may be associated with Application sharing/Desktop Sharing, a video quality, a video resolution, a video frame rate, or an audio quality.

Abstract: Embodiments of methods and systems for dominant speaker identification in video conferencing are described. In one embodiment, the computer-implemented method includes identifying one or more dominant speakers in a video conference. The method may also include generating a list of the one or more dominant speakers. Additionally, the method may include communicating the list of one or more dominant speakers to clients in a video conferencing system. In a further embodiment, the method includes communicating the list of the one or more dominant speakers to a client in response to the client joining the video conference.