Patents by Inventor M. Marshall
M. Marshall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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TECHNIQUES FOR REACTING TO DEVICE EVENT STATE CHANGES THAT ARE SHARED OVER A NETWORK OF USER DEVICES
Publication number: 20250202772Abstract: Techniques are disclosed for coordinating state information between devices in a network of devices. In one example, a first user device can obtain event information identifying an event (e.g., triggering of an alarm) associated with another user device and state information identifying a state of the other device. The first user device can report the state and event information to devices in the network. Observers corresponding to each user device can identify the occurrence of the event corresponding to the event information for each user device. An action (e.g., output an audio chime) can be performed by each device with an observer that identifies the occurrence of the event corresponding to the event information for each user device.Type: ApplicationFiled: December 20, 2024Publication date: June 19, 2025Applicant: Apple Inc.Inventors: Scott M. Marshall, Jiten L. Mehta, Darren S. Litzinger, Jeremy A. Wyld, John J. Iarocci -
Patent number: 12312418Abstract: Heterodimerizing domains with orthogonal mutations that drive heterodimerization, in particular heterodimerizing antibody CH3 domains, heterodimeric polypeptides comprising such heterodimerizing domains, and antibody constructs comprising such heterodimeric polypeptides, are provided.Type: GrantFiled: December 10, 2021Date of Patent: May 27, 2025Assignee: Invenra Inc.Inventors: Jonathan Harry Davis, Nicholas M. Marshall
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Patent number: 12255782Abstract: Techniques are disclosed for generating device cluster capability information for a cluster of devices in a network environment. Capability information can specify capabilities of the devices in the cluster. A first user device can generate device capabilities for the first user device and obtain device capabilities for other devices in the cluster. The first user device can generate cluster capability information providing an intersection of the first set of device capabilities and device capabilities of the other user devices in the cluster. The first user device can obtain cluster capability information for other clusters in the network environment and receive a request from a service user device to perform a specific task. The first user device can transmit cluster capability information relating to a selected cluster that corresponds with the request.Type: GrantFiled: June 29, 2023Date of Patent: March 18, 2025Assignee: Apple Inc.Inventors: Scott M. Marshall, Jeremy A. Wyld, Jiten L Mehta, Darren Litzinger, John J. Iarocci
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Publication number: 20250074577Abstract: The disclosure relates to a ducted fan aircraft propulsion system and to an aircraft incorporating such a propulsion system. Example embodiments include a ducted fan aircraft propulsion system (300), comprising: a duct (301); a central body portion (302) having first and second ends (303, 304) and extending through the duct (301); a payload portion (305) extending from the first end (303) of the central body portion (302); and a rotor (306) extending across an internal volume (307) of the duct (301) from the central body portion (302), wherein the duct (301) comprises an outwardly flared inlet end (308) such that an inlet air flow passage (309) between the central body portion (302) and an inner surface (310) of the duct (301) has a sectional area that decreases from the inlet end (308) of the duct (301) to the rotor (306).Type: ApplicationFiled: August 2, 2024Publication date: March 6, 2025Applicant: ROLLS-ROYCE plcInventors: Jonathan M. PARSONS, Elyse M Marshall, Sibylle Rerolle, Nadav Grunberg
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Publication number: 20250027094Abstract: The present invention provides engineered purine nucleoside phosphorylase (PNP) enzymes, polypeptides having PNP activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PNP enzymes are also provided. The present invention further provides compositions comprising the PNP enzymes and methods of using the engineered PNP enzymes. The present invention finds particular use in the production of pharmaceutical compounds.Type: ApplicationFiled: October 4, 2024Publication date: January 23, 2025Inventors: Scott J. Novick, Nikki Dellas, Vesna Mitchell, Da Duan, Jovana Nazor, Oscar Alvizo, Auric Anthony Sowell-Kantz, Jeffrey C. Moore, Mark A. Huffman, Agustina Rodriguez-Granillo, Deeptak Verma, Nicholas M. Marshall, Jay H. Russell, Keith A. Canada
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Techniques for reacting to device event state changes that are shared over a network of user devices
Patent number: 12177082Abstract: Techniques are disclosed for coordinating state information between devices in a network of devices. In one example, a first user device can obtain event information identifying an event (e.g., triggering of an alarm) associated with another user device and state information identifying a state of the other device. The first user device can report the state and event information to devices in the network. Observers corresponding to each user device can identify the occurrence of the event corresponding to the event information for each user device. An action (e.g., output an audio chime) can be performed by each device with an observer that identifies the occurrence of the event corresponding to the event information for each user device.Type: GrantFiled: March 18, 2022Date of Patent: December 24, 2024Assignee: Apple Inc.Inventors: Scott M. Marshall, Jiten L Mehta, Darren S. Litzinger, Jeremy A. Wyld, John J. Iarocci -
Publication number: 20240390415Abstract: Neuroprotective preparations (formulations) employing the synergistic, neurotrophic benefits of nutritional lithium with bioavailable magnesium (FIG. 1). The biological synergism of lithium and magnesium is further enhanced with a proprietary base of synergistic, neurotrophic nutrients. A highly-effective, trans-mucosal, delivery system is included to provide exceptional bioavailability of a palatable, convenient intra-oral preparation, which saturates the vascular tissue in the oral cavity for efficient absorption. Additionally, methods of use are described, allowing for effective, safe, and convenient use of this novel, neuroprotective, antioxidant, anti-inflammatory preparation for humans and animals.Type: ApplicationFiled: July 31, 2024Publication date: November 28, 2024Inventor: Timothy M. Marshall
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Patent number: 12110493Abstract: The present invention provides engineered purine nucleoside phosphorylase (PNP) enzymes, polypeptides having PNP activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PNP enzymes are also provided. The present invention further provides compositions comprising the PNP enzymes and methods of using the engineered PNP enzymes. The present invention finds particular use in the production of pharmaceutical compounds.Type: GrantFiled: September 30, 2021Date of Patent: October 8, 2024Assignee: Codexis, Inc.Inventors: Scott J. Novick, Nikki Dellas, Vesna Mitchell, Da Duan, Jovana Nazor, Oscar Alvizo, Auric Anthony Sowell-Kantz, Jeffrey C. Moore, Mark A. Huffman, Agustina Rodriguez-Granillo, Deeptak Verma, Nicholas M. Marshall, Jay H. Russell, Keith A. Canada
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Publication number: 20240285704Abstract: The compositions of this disclosure provide broad-spectrum nutrient supplementation to support the health of multiple organ and tissue systems in which mitochondrial function plays a fundamental role. In particular, the formulations promote neuroprotective, cardioprotective, immunosupportive, and anti-aging benefits. Also provided herein are novel, neuroprotective preparations containing a combination of broad- or full-spectrum hemp oil extract combined with niacinamide, a non-flushing form of vitamin B3, and methods of use are described allowing for safe, effective, and convenient use of a neuroprotective, antioxidant preparation for general and clinical use.Type: ApplicationFiled: January 8, 2024Publication date: August 29, 2024Inventor: Timothy M. Marshall
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Publication number: 20240287474Abstract: The present invention provides engineered galactose oxidase (GOase) enzymes, polypeptides having GOase activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing GOase enzymes are also provided. The present invention further provides compositions comprising the GOase enzymes and methods of using the engineered GOase enzymes. The present invention finds particular use in the production of pharmaceutical and other compounds.Type: ApplicationFiled: May 7, 2024Publication date: August 29, 2024Applicant: Codexis, Inc.Inventors: Christopher Micklitsch, Oscar Alvizo, Jovana Nazor, Harvinder Chagger Maniar, Mikayla Jianghongxia Krawczyk, Margie Tabuga Borra-Garske, Nandhitha Subramanian, Anna Fryszkowska, Nicholas M. Marshall, Agustina Rodriguez-Granillo, Deeptak Verma, Dewan Andrews
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Publication number: 20240199680Abstract: The present invention relates to efficient processes useful in the preparation of fluorinated cyclic dinucleosides, such as [P(R)]-2?-deoxy-2?-fluoro-5?-O—[(R)-hydroxymercaptophosphinyl]-P-thio-?-D-arabino-adenylyl-(3??5?)-3?-deoxy-3?-fluoroguanosine cyclic nucleotide, which is also known as (2R,5R,7R,8S,10R,12aR,14R,15S,15aR,16R)-7-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-15,16-difluoro-2, 10-bis(sulfanyl)octahydro-2H,10H, 12H-2?5,10?5-5,8-methanofuro[3,2-1][1, 3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.Type: ApplicationFiled: March 28, 2022Publication date: June 20, 2024Applicant: Merck Sharp & Dohme LLCInventors: Chihui An, Patrick S. Fier, Kaori Hiraga, Zhijian Liu, Nicholas M. Marshall, John McIntosh, Steven P. Miller, Jeffrey C. Moore, Grant S. Murphy, Jennifer V. Obligacion, Weilan Pan, Feng Peng, Nastaran Salehi Marzijarani, Matthew S. Winston
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Patent number: 12012618Abstract: The present invention provides engineered galactose oxidase (GOase) enzymes, polypeptides having GOase activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing GOase enzymes are also provided. The present invention further provides compositions comprising the GOase enzymes and methods of using the engineered GOase enzymes. The present invention finds particular use in the production of pharmaceutical and other compounds.Type: GrantFiled: September 9, 2022Date of Patent: June 18, 2024Assignee: Codexis, Inc.Inventors: Christopher Michael Micklitsch, Oscar Alvizo, Jovana Nazor, Harvinder Chagger Maniar, Mikayla Jianghongxia Krawczyk, Margie Tabuga Borra-Garske, Nandhitha Subramanian, Anna Fryszkowska, Nicholas M. Marshall, Agustina Rodriguez-Granillo, Deeptak Verma, Dewan Andrews
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SACCHARIDE-BASED ORAL MUCOADHESIVE DELIVERY SYSTEM FOR NEUROTROPHIC AND NEUROPROTECTIVE COMPOSITIONS
Publication number: 20240115493Abstract: The oral cavity is an ideal-site for small molecule, nutrient/nutraceutical delivery to the central nervous system (CNS) and systemic circulation due to the highly-vascularized, oral mucosa, near-neutral pH conditions, close proximity to the brain, and avoidance of gastric degradation and the first-pass effect. The rich-blood supply of the oral mucosa and “sticky”, mucoadhesive properties of this novel, saccharide-based, delivery system allows for the efficient absorption of small molecules across several highly-vascularized surfaces including the gingival, sublingual, soft-palatal, and buccal mucosa. Herein, I introduce a novel, saccharide-based, food-form, palatable, easy-to-administer, oral delivery system that attaches to these four, highly-absorptive surfaces for a longer contact-duration than current orally-available formulas resulting in greater, small molecule bioavailability, and a more rapid, therapeutic effect.Type: ApplicationFiled: December 19, 2023Publication date: April 11, 2024Inventor: Timothy M. Marshall -
Publication number: 20230344722Abstract: Techniques are disclosed for generating device cluster capability information for a cluster of devices in a network environment. Capability information can specify capabilities of the devices in the cluster. A first user device can generate device capabilities for the first user device and obtain device capabilities for other devices in the cluster. The first user device can generate cluster capability information providing an intersection of the first set of device capabilities and device capabilities of the other user devices in the cluster. The first user device can obtain cluster capability information for other clusters in the network environment and receive a request from a service user device to perform a specific task. The first user device can transmit cluster capability information relating to a selected cluster that corresponds with the request.Type: ApplicationFiled: June 29, 2023Publication date: October 26, 2023Applicant: Apple Inc.Inventors: Scott M. Marshall, Jeremy A. Wyld, Jiten L. Mehta, Darren Litzinger, John J. Iarocci
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Patent number: 11773445Abstract: In one aspect the invention relates to the use of single nucleotide polymorphisms (SNPs) in transient receptor potential (TRP) ion channel, acetylcholine receptor (AchR) and/or adrenergic receptor (ADR) genes as probes, tools or reagents for identifying, screening, diagnosing, monitoring or managing/treating subjects with, or predisposed to, medical conditions (or symptoms thereof), such as chronic fatigue syndrome (CFS), myalgic encephalomyelitis (ME), Gulf war syndrome (GWS), irritable bowel syndrome (IBS), multiple chemical sensitivity (MCS), fibromyalgia, and migraine, as well as some medical conditions caused by dysregulation in calcium, acetylcholine, TRP and ADR, and dysregulation in the gastrointestinal, cardiovascular, neurological, genitourinary and immune systems. In another aspect the invention relates to methods, kits and assays for identifying, screening, diagnosing, monitoring or managing/treating subjects with one or more of those medical conditions or symptoms.Type: GrantFiled: April 29, 2016Date of Patent: October 3, 2023Inventors: Sonya M. Marshall-Gradisnik, Donald R. Staines, Peter Kenneth Smith
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Patent number: 11736361Abstract: Techniques are disclosed for generating device cluster capability information for a cluster of devices in a network environment. Capability information can specify capabilities of the devices in the cluster. A first user device can generate device capabilities for the first user device and obtain device capabilities for other devices in the cluster. The first user device can generate cluster capability information providing an intersection of the first set of device capabilities and device capabilities of the other user devices in the cluster. The first user device can obtain cluster capability information for other clusters in the network environment and receive a request from a service user device to perform a specific task. The first user device can transmit cluster capability information relating to a selected cluster that corresponds with the request.Type: GrantFiled: December 13, 2022Date of Patent: August 22, 2023Assignee: Apple Inc.Inventors: Scott M. Marshall, Jeremy A. Wyld, Jiten L. Mehta, Darren Litzinger, John J. Iarocci
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Patent number: 11686470Abstract: A boiler includes a steam drum, an intermediate drum, and a lower drum. Each drum is divided into a clean section and a concentrated section. A channel that is fluidly connected to the clean section also runs down one side of the concentrated section in the intermediate drum and the lower drum. The presence of the channels permits low-quality feedwater tubes and high-quality feedwater tubes to be arranged in parallel rows next to each other.Type: GrantFiled: February 3, 2020Date of Patent: June 27, 2023Assignee: The Babcock & Wilcox CompanyInventors: Melvin J Albrecht, Jason M Marshall, Jonathan B Ford, Jeremy L Remus
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Publication number: 20230084026Abstract: Systems and methods provide customizable package options according to consumer preferences. Demand simulators may be used to guide the creation of selectable graphical objects representing optimized packages of features, which users may select from to form an insurance product appropriate for their particular needs. Packages may be formed with a particular appeal to consumers with common characteristics. In addition, methods and systems are provided for presenting insurance packages for consideration by customers over a network. Presented insurance packages may be formed through an optimization process or according to customer preferences.Type: ApplicationFiled: October 24, 2022Publication date: March 16, 2023Inventors: Floyd M. Yager, Thomas J. Wilson, Pamela M. Marshall, Sara P. Drexler
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Patent number: 11582110Abstract: Techniques are disclosed for generating device cluster capability information for a cluster of devices in a network environment. Capability information can specify capabilities of the devices in the cluster. A first user device can generate device capabilities for the first user device and obtain device capabilities for other devices in the cluster. The first user device can generate cluster capability information providing an intersection of the first set of device capabilities and device capabilities of the other user devices in the cluster. The first user device can obtain cluster capability information for other clusters in the network environment and receive a request from a service user device to perform a specific task. The first user device can transmit cluster capability information relating to a selected cluster that corresponds with the request.Type: GrantFiled: March 18, 2022Date of Patent: February 14, 2023Assignee: Apple Inc.Inventors: Scott M. Marshall, Jeremy A. Wyld, Jiten L. Mehta, Darren Litzinger, John J. Iarocci
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Publication number: 20230026007Abstract: The present invention provides engineered galactose oxidase (GOase) enzymes, polypeptides having GOase activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing GOase enzymes are also provided. The present invention further provides compositions comprising the GOase enzymes and methods of using the engineered GOase enzymes. The present invention finds particular use in the production of pharmaceutical and other compounds.Type: ApplicationFiled: September 9, 2022Publication date: January 26, 2023Inventors: Christopher Michael Micklitsch, Oscar Alvizo, Jovana Nazor, Harvinder Chagger Maniar, Mikayla Jianghongxia Krawczyk, Margie Tabuga Borra-Garske, Nandhitha Subramanian, Anna Fryszkowska, Nicholas M. Marshall, Agustina Rodriguez-Granillo, Deeptak Verma, Dewan Andrews