Patents by Inventor M. Marshall

M. Marshall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250202772
    Abstract: Techniques are disclosed for coordinating state information between devices in a network of devices. In one example, a first user device can obtain event information identifying an event (e.g., triggering of an alarm) associated with another user device and state information identifying a state of the other device. The first user device can report the state and event information to devices in the network. Observers corresponding to each user device can identify the occurrence of the event corresponding to the event information for each user device. An action (e.g., output an audio chime) can be performed by each device with an observer that identifies the occurrence of the event corresponding to the event information for each user device.
    Type: Application
    Filed: December 20, 2024
    Publication date: June 19, 2025
    Applicant: Apple Inc.
    Inventors: Scott M. Marshall, Jiten L. Mehta, Darren S. Litzinger, Jeremy A. Wyld, John J. Iarocci
  • Patent number: 12312418
    Abstract: Heterodimerizing domains with orthogonal mutations that drive heterodimerization, in particular heterodimerizing antibody CH3 domains, heterodimeric polypeptides comprising such heterodimerizing domains, and antibody constructs comprising such heterodimeric polypeptides, are provided.
    Type: Grant
    Filed: December 10, 2021
    Date of Patent: May 27, 2025
    Assignee: Invenra Inc.
    Inventors: Jonathan Harry Davis, Nicholas M. Marshall
  • Patent number: 12255782
    Abstract: Techniques are disclosed for generating device cluster capability information for a cluster of devices in a network environment. Capability information can specify capabilities of the devices in the cluster. A first user device can generate device capabilities for the first user device and obtain device capabilities for other devices in the cluster. The first user device can generate cluster capability information providing an intersection of the first set of device capabilities and device capabilities of the other user devices in the cluster. The first user device can obtain cluster capability information for other clusters in the network environment and receive a request from a service user device to perform a specific task. The first user device can transmit cluster capability information relating to a selected cluster that corresponds with the request.
    Type: Grant
    Filed: June 29, 2023
    Date of Patent: March 18, 2025
    Assignee: Apple Inc.
    Inventors: Scott M. Marshall, Jeremy A. Wyld, Jiten L Mehta, Darren Litzinger, John J. Iarocci
  • Publication number: 20250074577
    Abstract: The disclosure relates to a ducted fan aircraft propulsion system and to an aircraft incorporating such a propulsion system. Example embodiments include a ducted fan aircraft propulsion system (300), comprising: a duct (301); a central body portion (302) having first and second ends (303, 304) and extending through the duct (301); a payload portion (305) extending from the first end (303) of the central body portion (302); and a rotor (306) extending across an internal volume (307) of the duct (301) from the central body portion (302), wherein the duct (301) comprises an outwardly flared inlet end (308) such that an inlet air flow passage (309) between the central body portion (302) and an inner surface (310) of the duct (301) has a sectional area that decreases from the inlet end (308) of the duct (301) to the rotor (306).
    Type: Application
    Filed: August 2, 2024
    Publication date: March 6, 2025
    Applicant: ROLLS-ROYCE plc
    Inventors: Jonathan M. PARSONS, Elyse M Marshall, Sibylle Rerolle, Nadav Grunberg
  • Publication number: 20250027094
    Abstract: The present invention provides engineered purine nucleoside phosphorylase (PNP) enzymes, polypeptides having PNP activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PNP enzymes are also provided. The present invention further provides compositions comprising the PNP enzymes and methods of using the engineered PNP enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
    Type: Application
    Filed: October 4, 2024
    Publication date: January 23, 2025
    Inventors: Scott J. Novick, Nikki Dellas, Vesna Mitchell, Da Duan, Jovana Nazor, Oscar Alvizo, Auric Anthony Sowell-Kantz, Jeffrey C. Moore, Mark A. Huffman, Agustina Rodriguez-Granillo, Deeptak Verma, Nicholas M. Marshall, Jay H. Russell, Keith A. Canada
  • Patent number: 12177082
    Abstract: Techniques are disclosed for coordinating state information between devices in a network of devices. In one example, a first user device can obtain event information identifying an event (e.g., triggering of an alarm) associated with another user device and state information identifying a state of the other device. The first user device can report the state and event information to devices in the network. Observers corresponding to each user device can identify the occurrence of the event corresponding to the event information for each user device. An action (e.g., output an audio chime) can be performed by each device with an observer that identifies the occurrence of the event corresponding to the event information for each user device.
    Type: Grant
    Filed: March 18, 2022
    Date of Patent: December 24, 2024
    Assignee: Apple Inc.
    Inventors: Scott M. Marshall, Jiten L Mehta, Darren S. Litzinger, Jeremy A. Wyld, John J. Iarocci
  • Publication number: 20240390415
    Abstract: Neuroprotective preparations (formulations) employing the synergistic, neurotrophic benefits of nutritional lithium with bioavailable magnesium (FIG. 1). The biological synergism of lithium and magnesium is further enhanced with a proprietary base of synergistic, neurotrophic nutrients. A highly-effective, trans-mucosal, delivery system is included to provide exceptional bioavailability of a palatable, convenient intra-oral preparation, which saturates the vascular tissue in the oral cavity for efficient absorption. Additionally, methods of use are described, allowing for effective, safe, and convenient use of this novel, neuroprotective, antioxidant, anti-inflammatory preparation for humans and animals.
    Type: Application
    Filed: July 31, 2024
    Publication date: November 28, 2024
    Inventor: Timothy M. Marshall
  • Patent number: 12110493
    Abstract: The present invention provides engineered purine nucleoside phosphorylase (PNP) enzymes, polypeptides having PNP activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PNP enzymes are also provided. The present invention further provides compositions comprising the PNP enzymes and methods of using the engineered PNP enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
    Type: Grant
    Filed: September 30, 2021
    Date of Patent: October 8, 2024
    Assignee: Codexis, Inc.
    Inventors: Scott J. Novick, Nikki Dellas, Vesna Mitchell, Da Duan, Jovana Nazor, Oscar Alvizo, Auric Anthony Sowell-Kantz, Jeffrey C. Moore, Mark A. Huffman, Agustina Rodriguez-Granillo, Deeptak Verma, Nicholas M. Marshall, Jay H. Russell, Keith A. Canada
  • Publication number: 20240285704
    Abstract: The compositions of this disclosure provide broad-spectrum nutrient supplementation to support the health of multiple organ and tissue systems in which mitochondrial function plays a fundamental role. In particular, the formulations promote neuroprotective, cardioprotective, immunosupportive, and anti-aging benefits. Also provided herein are novel, neuroprotective preparations containing a combination of broad- or full-spectrum hemp oil extract combined with niacinamide, a non-flushing form of vitamin B3, and methods of use are described allowing for safe, effective, and convenient use of a neuroprotective, antioxidant preparation for general and clinical use.
    Type: Application
    Filed: January 8, 2024
    Publication date: August 29, 2024
    Inventor: Timothy M. Marshall
  • Publication number: 20240287474
    Abstract: The present invention provides engineered galactose oxidase (GOase) enzymes, polypeptides having GOase activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing GOase enzymes are also provided. The present invention further provides compositions comprising the GOase enzymes and methods of using the engineered GOase enzymes. The present invention finds particular use in the production of pharmaceutical and other compounds.
    Type: Application
    Filed: May 7, 2024
    Publication date: August 29, 2024
    Applicant: Codexis, Inc.
    Inventors: Christopher Micklitsch, Oscar Alvizo, Jovana Nazor, Harvinder Chagger Maniar, Mikayla Jianghongxia Krawczyk, Margie Tabuga Borra-Garske, Nandhitha Subramanian, Anna Fryszkowska, Nicholas M. Marshall, Agustina Rodriguez-Granillo, Deeptak Verma, Dewan Andrews
  • Publication number: 20240199680
    Abstract: The present invention relates to efficient processes useful in the preparation of fluorinated cyclic dinucleosides, such as [P(R)]-2?-deoxy-2?-fluoro-5?-O—[(R)-hydroxymercaptophosphinyl]-P-thio-?-D-arabino-adenylyl-(3??5?)-3?-deoxy-3?-fluoroguanosine cyclic nucleotide, which is also known as (2R,5R,7R,8S,10R,12aR,14R,15S,15aR,16R)-7-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-15,16-difluoro-2, 10-bis(sulfanyl)octahydro-2H,10H, 12H-2?5,10?5-5,8-methanofuro[3,2-1][1, 3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.
    Type: Application
    Filed: March 28, 2022
    Publication date: June 20, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Chihui An, Patrick S. Fier, Kaori Hiraga, Zhijian Liu, Nicholas M. Marshall, John McIntosh, Steven P. Miller, Jeffrey C. Moore, Grant S. Murphy, Jennifer V. Obligacion, Weilan Pan, Feng Peng, Nastaran Salehi Marzijarani, Matthew S. Winston
  • Patent number: 12012618
    Abstract: The present invention provides engineered galactose oxidase (GOase) enzymes, polypeptides having GOase activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing GOase enzymes are also provided. The present invention further provides compositions comprising the GOase enzymes and methods of using the engineered GOase enzymes. The present invention finds particular use in the production of pharmaceutical and other compounds.
    Type: Grant
    Filed: September 9, 2022
    Date of Patent: June 18, 2024
    Assignee: Codexis, Inc.
    Inventors: Christopher Michael Micklitsch, Oscar Alvizo, Jovana Nazor, Harvinder Chagger Maniar, Mikayla Jianghongxia Krawczyk, Margie Tabuga Borra-Garske, Nandhitha Subramanian, Anna Fryszkowska, Nicholas M. Marshall, Agustina Rodriguez-Granillo, Deeptak Verma, Dewan Andrews
  • Publication number: 20240115493
    Abstract: The oral cavity is an ideal-site for small molecule, nutrient/nutraceutical delivery to the central nervous system (CNS) and systemic circulation due to the highly-vascularized, oral mucosa, near-neutral pH conditions, close proximity to the brain, and avoidance of gastric degradation and the first-pass effect. The rich-blood supply of the oral mucosa and “sticky”, mucoadhesive properties of this novel, saccharide-based, delivery system allows for the efficient absorption of small molecules across several highly-vascularized surfaces including the gingival, sublingual, soft-palatal, and buccal mucosa. Herein, I introduce a novel, saccharide-based, food-form, palatable, easy-to-administer, oral delivery system that attaches to these four, highly-absorptive surfaces for a longer contact-duration than current orally-available formulas resulting in greater, small molecule bioavailability, and a more rapid, therapeutic effect.
    Type: Application
    Filed: December 19, 2023
    Publication date: April 11, 2024
    Inventor: Timothy M. Marshall
  • Publication number: 20230344722
    Abstract: Techniques are disclosed for generating device cluster capability information for a cluster of devices in a network environment. Capability information can specify capabilities of the devices in the cluster. A first user device can generate device capabilities for the first user device and obtain device capabilities for other devices in the cluster. The first user device can generate cluster capability information providing an intersection of the first set of device capabilities and device capabilities of the other user devices in the cluster. The first user device can obtain cluster capability information for other clusters in the network environment and receive a request from a service user device to perform a specific task. The first user device can transmit cluster capability information relating to a selected cluster that corresponds with the request.
    Type: Application
    Filed: June 29, 2023
    Publication date: October 26, 2023
    Applicant: Apple Inc.
    Inventors: Scott M. Marshall, Jeremy A. Wyld, Jiten L. Mehta, Darren Litzinger, John J. Iarocci
  • Patent number: 11773445
    Abstract: In one aspect the invention relates to the use of single nucleotide polymorphisms (SNPs) in transient receptor potential (TRP) ion channel, acetylcholine receptor (AchR) and/or adrenergic receptor (ADR) genes as probes, tools or reagents for identifying, screening, diagnosing, monitoring or managing/treating subjects with, or predisposed to, medical conditions (or symptoms thereof), such as chronic fatigue syndrome (CFS), myalgic encephalomyelitis (ME), Gulf war syndrome (GWS), irritable bowel syndrome (IBS), multiple chemical sensitivity (MCS), fibromyalgia, and migraine, as well as some medical conditions caused by dysregulation in calcium, acetylcholine, TRP and ADR, and dysregulation in the gastrointestinal, cardiovascular, neurological, genitourinary and immune systems. In another aspect the invention relates to methods, kits and assays for identifying, screening, diagnosing, monitoring or managing/treating subjects with one or more of those medical conditions or symptoms.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: October 3, 2023
    Inventors: Sonya M. Marshall-Gradisnik, Donald R. Staines, Peter Kenneth Smith
  • Patent number: 11736361
    Abstract: Techniques are disclosed for generating device cluster capability information for a cluster of devices in a network environment. Capability information can specify capabilities of the devices in the cluster. A first user device can generate device capabilities for the first user device and obtain device capabilities for other devices in the cluster. The first user device can generate cluster capability information providing an intersection of the first set of device capabilities and device capabilities of the other user devices in the cluster. The first user device can obtain cluster capability information for other clusters in the network environment and receive a request from a service user device to perform a specific task. The first user device can transmit cluster capability information relating to a selected cluster that corresponds with the request.
    Type: Grant
    Filed: December 13, 2022
    Date of Patent: August 22, 2023
    Assignee: Apple Inc.
    Inventors: Scott M. Marshall, Jeremy A. Wyld, Jiten L. Mehta, Darren Litzinger, John J. Iarocci
  • Patent number: 11686470
    Abstract: A boiler includes a steam drum, an intermediate drum, and a lower drum. Each drum is divided into a clean section and a concentrated section. A channel that is fluidly connected to the clean section also runs down one side of the concentrated section in the intermediate drum and the lower drum. The presence of the channels permits low-quality feedwater tubes and high-quality feedwater tubes to be arranged in parallel rows next to each other.
    Type: Grant
    Filed: February 3, 2020
    Date of Patent: June 27, 2023
    Assignee: The Babcock & Wilcox Company
    Inventors: Melvin J Albrecht, Jason M Marshall, Jonathan B Ford, Jeremy L Remus
  • Publication number: 20230084026
    Abstract: Systems and methods provide customizable package options according to consumer preferences. Demand simulators may be used to guide the creation of selectable graphical objects representing optimized packages of features, which users may select from to form an insurance product appropriate for their particular needs. Packages may be formed with a particular appeal to consumers with common characteristics. In addition, methods and systems are provided for presenting insurance packages for consideration by customers over a network. Presented insurance packages may be formed through an optimization process or according to customer preferences.
    Type: Application
    Filed: October 24, 2022
    Publication date: March 16, 2023
    Inventors: Floyd M. Yager, Thomas J. Wilson, Pamela M. Marshall, Sara P. Drexler
  • Patent number: 11582110
    Abstract: Techniques are disclosed for generating device cluster capability information for a cluster of devices in a network environment. Capability information can specify capabilities of the devices in the cluster. A first user device can generate device capabilities for the first user device and obtain device capabilities for other devices in the cluster. The first user device can generate cluster capability information providing an intersection of the first set of device capabilities and device capabilities of the other user devices in the cluster. The first user device can obtain cluster capability information for other clusters in the network environment and receive a request from a service user device to perform a specific task. The first user device can transmit cluster capability information relating to a selected cluster that corresponds with the request.
    Type: Grant
    Filed: March 18, 2022
    Date of Patent: February 14, 2023
    Assignee: Apple Inc.
    Inventors: Scott M. Marshall, Jeremy A. Wyld, Jiten L. Mehta, Darren Litzinger, John J. Iarocci
  • Publication number: 20230026007
    Abstract: The present invention provides engineered galactose oxidase (GOase) enzymes, polypeptides having GOase activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing GOase enzymes are also provided. The present invention further provides compositions comprising the GOase enzymes and methods of using the engineered GOase enzymes. The present invention finds particular use in the production of pharmaceutical and other compounds.
    Type: Application
    Filed: September 9, 2022
    Publication date: January 26, 2023
    Inventors: Christopher Michael Micklitsch, Oscar Alvizo, Jovana Nazor, Harvinder Chagger Maniar, Mikayla Jianghongxia Krawczyk, Margie Tabuga Borra-Garske, Nandhitha Subramanian, Anna Fryszkowska, Nicholas M. Marshall, Agustina Rodriguez-Granillo, Deeptak Verma, Dewan Andrews