Abstract: Provided herein are compositions comprising multi domain peptide (MDP) hydrogels where the peptides that constitute the hydrogel have at least one N6-(1-iminoethyl)-lysine side chain. Also provided are hydrogels that further comprise a STING agonist, an immune checkpoint inhibitor, and/or an anti-cancer therapy. Also provided are methods of using such compositions in the treatment of cancer.

Abstract: A universal bacterial assay and kit for detecting and monitoring changes in concentration of a target analyte in solution. The assay relies on an engineered high affinity protein-based sensor with a detectable label that has high specificity to a target analyte, typically a ligand or metallated complex, and can be used to spectroscopically monitor interaction of the target analyte with a test bacterial strain. The sensors can be in the form of living, transport-deficient bacterial cells expressing the engineered high affinity protein, or in the form of purified proteins themselves. The system can further be used to screen candidate compounds for interference with the binding and uptake of such analytes by bacterial cells, which is useful in investigation of new classes of antibiotics.

Abstract: Systems, methods, and instrumentalities are disclosed for Random Access Channel (RACH) procedures in unlicensed spectrum. A wireless transmit/receive unit (WTRU) may monitor for a random access response (RAR) or a reference signal (RS), e.g. in an RAR window. The WTRU may determine whether an RS has been received a threshold amount of times, e.g. if an RAR is not received. The WTRU may continue to monitor for an RAR or an RS, e.g. if the RS has not been received a threshold amount of times and the RAR window is not at a maximum RAR window size.

Abstract: A universal bacterial assay and kit for detecting and monitoring changes in concentration of a target analyte in solution. The assay relies on an engineered high affinity protein-based sensor with a detectable label that has high specificity to a target analyte, typically a ligand or metallated complex, and can be used to spectroscopically monitor interaction of the target analyte with a test bacterial strain. The sensors can be in the form of living, transport-deficient bacterial cells expressing the engineered high affinity protein, or in the form of purified proteins themselves. The system can further be used to screen candidate compounds for interference with the binding and uptake of such analytes by bacterial cells, which is useful in investigation of new classes of antibiotics.

Abstract: Provided herein are compositions comprising multi domain peptide (MDP) hydrogels where the peptides that constitute the hydrogel have at least one N6-(1-iminoethyl)-lysine side chain. Also provided are hydrogels that further comprise a STING agonist, an immune checkpoint inhibitor, and/or an anti-cancer therapy. Also provided are methods of using such compositions in the treatment of cancer.

Abstract: Systems, methods, and instrumentalities are disclosed for Random Access Channel (RACH) procedures in unlicensed spectrum. A wireless transmit/receive unit (WTRU) may monitor for a random access response (RAR) or a reference signal (RS), e.g. in an RAR window. The WTRU may determine whether an RS has been received a threshold amount of times, e.g. if an RAR is not received. The WTRU may continue to monitor for an RAR or an RS, e.g. if the RS has not been received a threshold amount of times and the RAR window is not at a maximum RAR window size.

Abstract: A cell-based assay for identifying a compound that inhibits iron transport in Gram-negative bacteria, engineered bacterial cells, and kits for conducting the same. The assay involves contacting a candidate compound with an engineered Gram-negative bacteria in the presence of iron for a sufficient period of time, exposing the reaction solution to an energy source to generate the detectable signal, and detecting changes in the detectable signal in the reaction solution over time. The engineered Gram-negative bacteria comprises an iron transport protein on its outer membrane that comprises an amino acid residue that has been engineered with a detectable label that generates a detectable signal. The changes in the detectable signal in the assay system over time correspond to the effect of the candidate compound on iron transport in the Gram-negative bacteria.

Abstract: Embodiments of the disclosure concern methods and compositions for treating cancer in an individual that includes combination therapy comprising radiofrequency therapy and immunotherapy. In specific embodiments, utilization of the radiofrequency therapy invokes the immune system of the individual to provide an environment at the tumor that is receptive to native immune system components of the individual, and/or exogenously provided immune system components. In specific cases, the radiofrequency therapy enhances T cell localization to the tumor.

Abstract: A method of building a three dimensional (3D) structure includes micro-dispensing a layer comprising a material using a syringe-based micro-dispensing tool, curing the layer, and repeating the steps of micro-dispensing and curing a plurality of times in order to build the three-dimensional structure. The material may be loaded with nano to micron sized particles, tubes, or strings.

Abstract: A cell-based assay for identifying a compound that inhibits iron transport in Gram-negative bacteria, engineered bacterial cells, and kits for conducting the same. The assay involves contacting a candidate compound with an engineered Gram-negative bacteria in the presence of iron for a sufficient period of time, exposing the reaction solution to an energy source to generate the detectable signal, and detecting changes in the detectable signal in the reaction solution over time. The engineered Gram-negative bacteria comprises an iron transport protein on its outer membrane that comprises an amino acid residue that has been engineered with a detectable label that generates a detectable signal. The changes in the detectable signal in the assay system over time correspond to the effect of the candidate compound on iron transport in the Gram-negative bacteria.

Abstract: A radar warning receiver system includes an electronic radar receiver unit configured to generate at least one excitation pulse. The at least one excitation pulse initializes at least one antenna during a respective dwell time to receive at least one radar wave output by an active emitter of an active threat object. An electronic enhanced receiver scheduler unit includes a microcontroller configured to determine at least two threat objects from a plurality of possible threat objects. The microcontroller generates at least one enhanced hybrid pattern including a series of non-continuous dwell times respective to each of the at least two determined threat objects. The radar receiver unit generates the at least one excitation pulse according to the enhanced pattern so as to detect the at least two determined threat objects.

Abstract: A radar warning receiver system includes an electronic radar receiver unit configured to generate at least one excitation pulse. The at least one excitation pulse initializes at least one antenna during a respective dwell time to receive at least one radar wave output by an active emitter of an active threat object. An electronic enhanced receiver scheduler unit includes a microcontroller configured to determine at least two threat objects from a plurality of possible threat objects. The microcontroller generates at least one enhanced hybrid pattern including a series of non-continuous dwell times respective to each of the at least two determined threat objects. The radar receiver unit generates the at least one excitation pulse according to the enhanced pattern so as to detect the at least two determined threat objects.

Abstract: An emergency temporary spent fuel pool cooling system for a nuclear power generating facility that has a permanently installed primary loop within the nuclear containment and a mobile temporary secondary loop. The secondary loop is housed in transport vehicles that can be stored off site and is connectable in heat exchange relationship with the primary loop through quick disconnect couplings that are accessible on the outside of the reactor containment. The transport vehicles also include self-contained power and compressed air sources for powering and controlling the entire emergency cooling system. The system also has a make-up water injection capability for refueling the spent fuel pool and secondary loop.

Abstract: The method and system for a material cabinet for use in cooperation with a plurality of articles stored in the material cabinet is disclosed. Each of the plurality of articles having a radio frequency identification tag attached thereto is connected through at least an antenna or a plurality of antennas installed in the material cabinet to a radio frequency identification reader, which is interpreted through a software in a computer system. This method and system has capability to effectuate point of use control of the stored articles through a database in the computer system. This method and system also implements a security mechanism through a lock system to secure the store articles from unauthorized user/stock clerks.

Abstract: A wireless transmit/receive unit (WTRU) is described. The WTRU includes a front-end unit (FEU), a signal processing unit (SPU), and a resource management unit (RMU). The FEU receives a radio frequency (RF) signal, generates time-interleaved samples, an includes: a first array of first time-interleaved samplers, a second array of second time-interleaved samplers, and a third array of third time-interleaved samplers. The SPU receives and combines the plurality of time-interleaved samples and generates a signal quality measurement and in-phase and quadrature-phase (IQ) complex samples. The RMU receives the signal quality measurement and allocates FEU resources in conjunction with a front-end unit controller (FEUC) based on the signal quality measurement. The FEUC generates control signals based on the received signal quality measurement from the RMU.

Abstract: A wireless transmit/receive unit (WTRU) is described. The WTRU includes a front-end unit (FEU), a signal processing unit (SPU), and a resource management unit (RMU). The FEU receives a radio frequency (RF) signal, generates time-interleaved samples, an includes: a first array of first time-interleaved samplers, a second array of second time-interleaved samplers, and a third array of third time-interleaved samplers. The SPU receives and combines the plurality of time-interleaved samples and generates a signal quality measurement and in-phase and quadrature-phase (IQ) complex samples. The RMU receives the signal quality measurement and allocates FEU resources in conjunction with a front-end unit controller (FEUC) based on the signal quality measurement. The FEUC generates control signals based on the received signal quality measurement from the RMU.

Abstract: Bipolar transistors with tailored response curves, as well as fabrication methods for bipolar transistors and design structures for BiCMOS integrated circuits. The bipolar transistor includes a first section of a collector region implanted with a first dopant concentration and a second section of the collector region implanted with a second dopant concentration that is higher than the first dopant concentration. A first emitter is formed in vertical alignment with the first section of the collector region. A second emitter is formed in vertical alignment with the second section of the collector region.

Abstract: A method and apparatus for dynamic resource allocation of an RF sampling system based on a signal quality measurement determined by generating a plurality of time-interleaved samples from a received radio frequency (RF) signal and combining the plurality of time-interleaved samples to generate the signal quality.

Abstract: An emergency temporary spent fuel pool cooling system for a nuclear power generating facility that has a permanently installed primary loop within the nuclear containment and a mobile temporary secondary loop. The secondary loop is housed in transport vehicles that can be stored off site and is connectable in heat exchange relationship with the primary loop through quick disconnect couplings that are accessible on the outside of the reactor containment. The transport vehicles also include self-contained power and compressed air sources for powering and controlling the entire emergency cooling system. The system also has a make-up water injection capability for refueling the spent fuel pool and secondary loop.

Abstract: A method is provided for decontaminating biological pathogens residing in an enclosure of an electronic device. The method includes: identifying materials used to encase the enclosure of the electronic device; tailoring x-ray radiation to penetrate the materials encasing the enclosure; and directing x-ray radiation having a diffused radiation angle towards the electronic device.