Patents by Inventor Mónika Megyesi
Mónika Megyesi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240000911Abstract: The disclosure relates to polypeptides and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer, in particular gastric cancer, lung cancer, melanoma and bladder cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods of identifying subjects for treatment. The peptides comprise T cell epitopes that are immunogenic in a high percentage of patients.Type: ApplicationFiled: May 2, 2023Publication date: January 4, 2024Inventors: Julianna Lisziewicz, Levente Molnár, Eniko Toke, József Toth, Orsolya Lorincz, Zsolt Csiszovszki, Eszter Somogyi, Katalin Pántya, Mónika Megyesi
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Publication number: 20230405100Abstract: The disclosure relates to polypeptides and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer, in particular breast cancer, ovarian cancer and colorectal cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods of identifying subjects for treatment. The peptides comprise T cell epitopes that are immunogenic in a high percentage of patients.Type: ApplicationFiled: February 8, 2023Publication date: December 21, 2023Inventors: Julianna Lisziewicz, Levente Molnár, Eniko R. Toke, József Toth, Orsolya Lorincz, Zsolt Csiszovszki, Eszter Somogyi, Katalin Pántya, Mónika Megyesi
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Patent number: 11666644Abstract: The disclosure relates to polypeptides and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer, in particular gastric cancer, lung cancer, melanoma and bladder cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods of identifying subjects for treatment. The peptides comprise T cell epitopes that are immunogenic in a high percentage of patients.Type: GrantFiled: September 3, 2019Date of Patent: June 6, 2023Assignee: Treos Bio LimitedInventors: Julianna Lisziewicz, Levente Molnar, Eniko Toke, József Toth, Orsolya Lorincz, Zsolt Csiszovszki, Eszter Somogyi, Katalin Pantya, Mónika Megyesi
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Patent number: 11628211Abstract: The disclosure relates to polypeptides and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer, in particular breast cancer, ovarian cancer and colorectal cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods of identifying subjects for treatment. The peptides comprise T cell epitopes that are immunogenic in a high percentage of patients.Type: GrantFiled: December 22, 2021Date of Patent: April 18, 2023Assignee: Treos Bio LimitedInventors: Julianna Lisziewicz, Levente Molnár, Eniko R. Toke, József Toth, Orsolya Lorincz, Zsolt Csiszovszki, Eszter Somogyi, Katalin Pántya, Mónika Megyesi
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Publication number: 20230102031Abstract: The disclosure relates to polypeptides and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer, in particular gastric cancer, lung cancer, melanoma and bladder cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods of identifying subjects for treatment. The peptides comprise T cell epitopes that are immunogenic in a high percentage of patients.Type: ApplicationFiled: September 3, 2019Publication date: March 30, 2023Inventors: Julianna LISZEWICZ, Levente MOLNAR, Eniko TOKE, József TOTH, Orsolya LORINCZ, Zsolt CSISZOVSZKI, Eszter SOMOGYI, Katalin PANTYA, Mónika MEGYESI
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Patent number: 11426452Abstract: The disclosure relates to polypeptides and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer, in particular breast cancer, ovarian cancer and colorectal cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods of identifying subjects for treatment. The peptides comprise T cell epitopes that are immunogenic in a high percentage of patients.Type: GrantFiled: December 22, 2021Date of Patent: August 30, 2022Assignee: Treos Bio LimitedInventors: Julianna Lisziewicz, Levente Molnár, Eniko R. Toke, József Toth, Orsolya Lorincz, Zsolt Csiszovszki, Eszter Somogyi, Katalin Pántya, Mónika Megyesi
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Publication number: 20220233660Abstract: The disclosure relates to a method for determining the risk that a human subject will develop a cancer, the method comprising quantifying the HLA triplets (HEAT) of the subject that are capable of binding to T cell epitopes in the amino acid sequence of tumor associated antigens. The disclosure also relates to methods of treating subjects who are determined to have an elevated risk of developing cancer.Type: ApplicationFiled: September 3, 2019Publication date: July 28, 2022Inventors: Julianna LISZEWICZ, Levente MOLNAR, Eniko TOKE, József TOTH, Orsolya LORINCZ, Zsolt CSISZOVSZKI, Eszter SOMOGYI, Katalin PANTYA, Péter PÁLES, István MIKLÓS, Mónika MEGYESI
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Publication number: 20220160854Abstract: The disclosure relates to polypeptides, polynucleic acids and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods. The disclosure also relates to a method of preparing a peptide or polynucleic acid for use in a method of inducing a T cell response against a target polypeptide, wherein the method comprises identifying epitopes in the antigen that bind to multiple alleles of receptors of the highest proportion of subjects in a target population.Type: ApplicationFiled: February 8, 2022Publication date: May 26, 2022Inventors: Levente Molnár, Eniko R. Toke, Julianna Lisziewicz, József Tóth, Orsolya Lorincz, Zsolt Csiszovszki, Eszter Somogyi, Katalin Pántya, Mónika Megyesi, Péter Páles
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Publication number: 20220111025Abstract: The disclosure relates to polypeptides and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer, in particular breast cancer, ovarian cancer and colorectal cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods of identifying subjects for treatment. The peptides comprise T cell epitopes that are immunogenic in a high percentage of patients.Type: ApplicationFiled: December 22, 2021Publication date: April 14, 2022Inventors: Julianna Lisziewicz, Levente Molnár, Eniko R. Toke, József Toth, Orsolya Lorincz, Zsolt Csiszovszki, Eszter Somogyi, Katalin Pántya, Mónika Megyesi
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Publication number: 20220111024Abstract: The disclosure relates to polypeptides and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer, in particular breast cancer, ovarian cancer and colorectal cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods of identifying subjects for treatment. The peptides comprise T cell epitopes that are immunogenic in a high percentage of patients.Type: ApplicationFiled: December 22, 2021Publication date: April 14, 2022Inventors: Julianna Lisziewicz, Levente Molnár, Eniko R. Toke, József Toth, Orsolya Lorincz, Zsolt Csiszovszki, Eszter Somogyi, Katalin Pántya, Mónika Megyesi
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Publication number: 20220072114Abstract: The disclosure relates to methods of identifying fragments of a polypeptide that are immunogenic for a specific human subject, methods of preparing pharmaceutical compositions comprising such polypeptide fragments, pharmaceutical compositions comprising such polypeptide fragments, and methods of treatment using such compositions. The methods comprise identifying a fragment of the polypeptide that binds to multiple HLA of individual subjects.Type: ApplicationFiled: November 9, 2021Publication date: March 10, 2022Inventors: Julianna Lisziewicz, Levente Molnár, Eniko R. Toke, József Toth, Orsolya Lorincz, Zsolt Csiszovszki, Eszter Somogyi, Katalin Pántya, Mónika Megyesi
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Publication number: 20220031823Abstract: The disclosure relates to methods of identifying fragments of a polypeptide that are immunogenic for a specific human subject, methods of preparing personalised pharmaceutical compositions comprising such polypeptide fragments, human subject-specific pharmaceutical compositions comprising such polypeptide fragments, and methods of treatment using such compositions. The methods comprise identifying a fragment of the polypeptide that binds to multiple HLA of the subject.Type: ApplicationFiled: September 17, 2021Publication date: February 3, 2022Inventors: Julianna Lisziewicz, Levente Molnár, Eniko R. Toke, József Toth, Orsolya Lorincz, Zsolt Csiszovszki, Eszter Somogyi, Katalin Pántya, Mónika Megyesi
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Patent number: 11213578Abstract: The disclosure relates to polypeptides and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer, in particular breast cancer, ovarian cancer and colorectal cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods of identifying subjects for treatment. The peptides comprise T cell epitopes that are immunogenic in a high percentage of patients.Type: GrantFiled: January 10, 2019Date of Patent: January 4, 2022Assignee: Treos Bio LimitedInventors: Julianna Lisziewicz, Levente Molnár, Enikő R. Tőke, József Toth, Orsolya Lorincz, Zsolt Csiszovszki, Eszter Somogyi, Katalin Pántya, Mónika Megyesi
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Publication number: 20210236611Abstract: The disclosure relates to polypeptides, polynucleic acids and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods. The disclosure also relates to a method of preparing a peptide or polynucleic acid for use in a method of inducing a T cell response against a target polypeptide, wherein the method comprises identifying epitopes in the antigen that bind to multiple alleles of receptors of the highest proportion of subjects in a target population.Type: ApplicationFiled: February 26, 2021Publication date: August 5, 2021Inventors: Levente MOLNÁR, Eniko R. TOKE, Julianna LISZIEWICZ, József TÓTH, Orsolya LORINCZ, Zsolt CSISZOVSZKI, Eszter SOMOGYI, Katalin PÁNTYA, Mónika MEGYESI, Péter PÁLES
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Publication number: 20200069786Abstract: The disclosure relates to polypeptides, polynucleic acids and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods. The disclosure also relates to a method of preparing a peptide or polynucleic acid for use in a method of inducing a T cell response against a target polypeptide, wherein the method comprises identifying epitopes in the antigen that bind to multiple HLA alleles of the highest proportion of subjects in a target population.Type: ApplicationFiled: September 3, 2019Publication date: March 5, 2020Inventors: Levente MOLNÁR, Enikõ R. TÕKE, Julianna LISZEWICZ, József TÓTH, Orsolya LÕRINCZ, Zsolt CSISZOVSZKI, Eszter SOMOGYI, Katalin PÁNTYA, Mónika MEGYESI, Péter PÁLES
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Publication number: 20190240302Abstract: The disclosure relates to polypeptides and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer, in particular breast cancer, ovarian cancer and colorectal cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods of identifying subjects for treatment. The peptides comprise T cell epitopes that are immunogenic in a high percentage of patients.Type: ApplicationFiled: January 10, 2019Publication date: August 8, 2019Inventors: Julianna LISZIEWICZ, Levente MOLNÁR, Eniko R. TOKE, József TOTH, Orsolya LORINCZ, Zsolt CSISZOVSZKI, Eszter SOMOGYI, Katalin PÁNTYA, Mónika MEGYESI
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Patent number: 10213497Abstract: The disclosure relates to polypeptides and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer, in particular breast cancer, ovarian cancer and colorectal cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods of identifying subjects for treatment. The peptides comprise T cell epitopes that are immunogenic in a high percentage of patients.Type: GrantFiled: March 2, 2018Date of Patent: February 26, 2019Assignee: TREOS BIO ZRT.Inventors: Julianna Lisziewicz, Levente Molnár, Eniko R. Toke, József Toth, Orsolya Lorincz, Zsolt Csiszovszki, Eszter Somogyi, Katalin Pántya, Mónika Megyesi
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Publication number: 20180264094Abstract: The disclosure relates to methods of identifying fragments of a polypeptide that are immunogenic for a specific human subject, methods of preparing personalised pharmaceutical compositions comprising such polypeptide fragments, human subject-specific pharmaceutical compositions comprising such polypeptide fragments, and methods of treatment using such compositions. The methods comprise identifying a fragment of the polypeptide that binds to multiple HLA of the subject.Type: ApplicationFiled: March 2, 2018Publication date: September 20, 2018Inventors: Julianna LISZIEWICZ, Levente MOLNÁR, Enikö R. TÖKE, József TOTH, Orsolya LORINCZ, Zsolt CSISZOVSZKI, Eszter SOMOGYI, Katalin PÁNTYA, Mónika MEGYESI
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Publication number: 20180264095Abstract: The disclosure relates to methods of identifying fragments of a polypeptide that are immunogenic for a specific human subject, methods of preparing pharmaceutical compositions comprising such polypeptide fragments, pharmaceutical compositions comprising such polypeptide fragments, and methods of treatment using such compositions. The methods comprise identifying a fragment of the polypeptide that binds to multiple HLA of individual subjects.Type: ApplicationFiled: March 2, 2018Publication date: September 20, 2018Inventors: Julianna LISZIEWICZ, Levente MOLNÁR, Enikõ R. TÖKE, József TOTH, Orsolya LORINCZ, Zsolt CSISZOVSZKI, Eszter SOMOGYI, Katalin PÁNTYA, Mónika MEGYESI
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Publication number: 20180250399Abstract: The disclosure relates to polypeptides and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer, in particular breast cancer, ovarian cancer and colorectal cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods of identifying subjects for treatment. The peptides comprise T cell epitopes that are immunogenic in a high percentage of patients.Type: ApplicationFiled: March 2, 2018Publication date: September 6, 2018Inventors: Julianna Lisziewicz, Levente Molnár, Enikö R. Töke, József Toth, Orsolya Lorincz, Zsolt Csiszovszki, Eszter Somogyi, Katalin Pántya, Mónika Megyesi