Abstract: The present invention relates to a novel class of compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.

Abstract: The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.

Abstract: The invention relates to inhibitors of kinases, compositions comprising the inhibitors, and methods of using the inhibitors and inhibitor compositions. The inhibitors and compositions comprising them are useful for treating disease or disease symptoms. The invention also provides for methods of making kinase inhibitor compounds, methods of inhibiting kinase activity, and methods for treating disease or disease symptoms.

Abstract: A thermal image identification system includes an infrared emitting element having a laminate, and a power source electrically communicable with the infrared emitting element. The laminate includes an infrared emitting layer having a first side and a second side, a cover layer associated with the first side, and a backing layer associated with the second side. The laminate may also include a first heat insulating layer between the infrared emitting layer and the cover layer, a second heat insulating layer between the infrared emitting layer and the backing layer, and an infrared reflective layer between the second heat insulating layer and the backing layer. A plurality of infrared emitting elements may be arranged contiguously for coordinated operation. The infrared emitting elements may be arranged in a one-dimensional or a two-dimensional array.

Abstract: A method for producing a polymer by coordination polymerization, comprising the steps of (a) reacting an unsaturated polar monomer having a functional group releasing a proton or a salt of the unsaturated polar monomer, with a masking agent comprising a halogenated organometallic compound or a organoaluminum compound capable of masking the functional group to form a corresponding masked monomer; and (b) polymerizing the masked monomer either alone or in combination with another monomer in the presence of the coordination polymerization catalyst to obtain the polymer.

Abstract: The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.

Abstract: The present invention relates to compounds, methods and pharmaceutical compositions for stimulating the growth of neurites in nerve cells. The compounds and the compositions and methods that utilize them can be used, either alone or in conjunction with a neurotrophic factor, such as nerve growth factor, to promote repair of neuronal damage caused by disease or physical trauma.

Abstract: A candle snuffing device for snuffing out a candle without producing smoke. The candle snuffing device includes a housing. The housing has a front wall, a back wall and a peripheral wall integrally coupled to and extending between the front and back walls. A first tubular member is elongate and has a first end and a second end. The first tubular member is securely coupled to the housing such that the first end of the first tubular member extends into housing. A reservoir for holding a fluid is positioned in the housing. A pumping means for pumping liquid out of the reservoir is fluidly coupled to the reservoir and extends outwardly from the housing through the peripheral wall. A hose member has a first end and a second end. The first end is mechanically coupled to the pumping means. The hose member extending through the reservoir and through the first tubular member. A block member has a front side, a back side, and a perimeter edge extending therebetween.

Abstract: The present invention relates to compounds, methods and pharmaceutical compositions for stimulating the growth of neurites in nerve cells. The compounds and the compositions and methods that utilize them can be used, either alone or in conjunction with a neurotrophic factor, such as nerve growth factor, to promote repair of neuronal damage caused by disease or physical trauma.

Abstract: An adjustable child car seat (100) includes a base (110) with a pivot rod (174) at one end and a level adjuster receptor (140) with a plurality of adjust positions (150) at an opposite end. A recliner (114) is carried by the base (110) at the pivot rod (174). The recliner (114) provides a level adjuster (250) that is selectively moveable into any one of the adjust positions (150). The recliner also provides a seat recline level adjuster receptor (220) with a plurality of recline positions (224). A car seat (102) is pivotably mounted to the recliner (114) by a seat pin (126). A seat recline adjuster (300) is slidably mounted to the car seat and is selectively moveable into one of the recline positions. Accordingly, the level adjuster (250) allows positioning of the base (110) to the angle of the supporting seat. Further adjustment is permitted by moving the seat with respect to the recliner.

Abstract: The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.

Abstract: Providing an isomerization process which can isomerize allenes to alkynes less expensively and stably is an assignment to be solved by the present invention and given thereto. The present invention is an isomerization process including the step of reacting an allene-lype hydrocarbon compound (R.sub.1 R.sub.2 C.dbd.C.dbd.CR.sub.3 R.sub.4) in the presence of alkaline-earth metal hydride working as an isomerization catalyst, thereby isomerizing the allene-type hydrocarbon compound to an alkyne-type hydrocarbon compound (R.sub.1 C.ident.C--CR.sub.2 R.sub.3 R.sub.4).

Abstract: The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.

Abstract: Cholesteric copolyisocyanates with repeating units of the formulae: ##STR1## and, where appropriate, of the formula ##STR2## where R.sup.1 is a chiral aliphatic or aromatic radical,R.sup.2 is a crosslinkable radical, andR.sup.3 is an achiral radical,and polymers obtainable by crosslinking the copolyisocyanates according to the invention with a polymerizable solvent, and pigments comprising the polymers according to the invention, are described.

Abstract: The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as agents for immunosuppression. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.

Abstract: The invention features linear copolymers prepared from mixtures of allenes and alkynes. The new copolymers have the formula: ##STR1## wherein R.sub.1 through R.sub.6 are, independently, H, an alkyl, an aryl, a phenyl or substituted phenyl, an alkoxy, or an aryloxyl, x+n is 1 to 10,000, and m is 1 to 10,000. The invention also features efficient methods of preparing the new copolymers using nickel or palladium catalysts.

Abstract: An automated check-out system for retail stores, such as supermarkets, employing digitized video signals and other means to determine and differentiate individual products, and thereby register the data for billing and inventory purposes. The sensors control the flow and positioning of retail items into the housing wherein the light source is regulated and controlled. Within the housing, optical imaging of the retail item is made with the electronic signal being digitized. By use of computerized databases, the digitized signal is compared to the finite set of data for products of approximately the same size, shape, weight and other comparative variables. Further confirmation of product identity is achieved by use of bar code differentiation, multiple image comparisons and, if necessary, optical display to the store personnel operating the cash register station serving multiple check-out lanes within the store. The customer is guided through the transaction by use of a video display screen.

Abstract: "Living" polymerization methods are described wherein a bimetallic lanthanide complex initiator is reacted with a monomer. Using these methods, link-functionalized polymers can be formed that are capable of being modified after polymerization with various reactants, or to be biodegraded through oxidation or reduction or cleavage. The bimetallic lanthanide complex initiator can be used to polymerize methyl methacrylate in a living fashion. A two-step method of forming a triblock polymer using the bimetallic lanthanide complex initiator is also disclosed.

Abstract: An apparatus controls an appliance, the appliance including a compressor, a fan, and a heater. The apparatus includes a first switch for selectively coupling a first terminal with one of a second terminal and a third terminal in response to a first control signal. The first terminal is coupled with an energy source and the third terminal is coupled with the compressor. The apparatus further includes a second switch for selectively coupling the second terminal with the heater and the third terminal with the fan in response to a second control signal. The apparatus still further includes a control circuit coupled with the first switch and the second switch for generating the first control signal and the second control signal. A relay drive circuit couples relay coils in series to control the first switch, the second switch, and the third switch. A bypass switch allows a single current to selectively energize one or both relay coils.

Abstract: A point of sale (POS) bar code scanner such as in common use in retail stores includes provision for reading bar coded redemption coupons (or other bar coded documents redeemable for value) in a manner secure from a human operator. Integration of functions between the POS scanner and the coupon reader varies with different embodiments described. Through software associated with bar code decoding logic, a comparison is made between information on a validation coupon and information on items presented for purchase, and a decision is made as to whether the redemption coupon is valid and redeemable in this transaction. In one embodiment, the bar code scanner simply receives the redemption coupon face down on the product scanner window, and integrated decode logic of the scanner identifies the bar code as belonging to a redemption coupon, then makes the comparison and validation of the coupon for the particular transaction.