Patents by Inventor M. RAMAMOHAN

M. RAMAMOHAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preparing (R)-N-[4-(1-amino-ethyl)-2,6-difluoro-phenyl]-methanesulfonamide
    Patent number: 10858315
    Abstract: Disclosed in the present specification is a method capable of preparing N-[4-[(1R)-1-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]ethyl]-2,6-difluorophenyl]-methanesulfonamide (INT028-2) with high optical purity, through the selection of Ellman-chiral auxiliaries and the recrystallization and separation of optical isomers. According to the above method, high-purity N-[4-[(1R)-1-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]ethyl]-2,6-difluorophenyl]-methanesulfonamide with excellent quality can be produced at room temperature by improving cryogenic process conditions necessary for realizing high optical purity, and thus the trimming due to the process failure rate can be remarkably reduced.
    Type: Grant
    Filed: September 26, 2017
    Date of Patent: December 8, 2020
    Assignee: AMOREPACIFIC CORPORATION
    Inventors: Byoung Young Woo, Ki-Wha Lee, Jihae Lee, Chang Soon Choi, Miyoung Park, Young-Ho Park, Sarva Jayaprakash, Sridhar Regati, Mamidi Srinivas, Krushnakant Patel, M. Ramamohan
  • METHOD FOR PREPARING (R)-N-[4-(1-AMINO-ETHYL)-2,6-DIFLUORO-PHENYL]-METHANESULFONAMIDE
    Publication number: 20200031766
    Abstract: Disclosed in the present specification is a method capable of preparing N-[4-[(1R)-1-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]ethyl]-2,6-difluorophenyl]-methanesulfonamide (INT028-2) with high optical purity, through the selection of Ellman-chiral auxiliaries and the re-crystallization and separation of optical isomers. According to the above method, high-purity N-[4-[(1R)-1-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]ethyl]-2,6-difluorophenyl]-methanesulfonamide with excellent quality can be produced at room temperature by improving cryogenic process conditions necessary for realizing high optical purity, and thus the trimming due to the process failure rate can be remarkably reduced.
    Type: Application
    Filed: September 26, 2017
    Publication date: January 30, 2020
    Applicant: Amorepacific Corporation
    Inventors: Byoung Young WOO, Ki-Wha LEE, Jihae LEE, Chang Soon CHOI, Miyoung PARK, Young-Ho PARK, Sarva JAYAPRAKASH, Sridhar REGATI, Mamidi SRINIVAS, Krushnakant PATEL, M. RAMAMOHAN