Patents by Inventor Márcio Luis Andrade Silva

Márcio Luis Andrade Silva has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process to obtain dibenzylbutyrolactonic lignans, process to obtain synthetic derivatives from lignans bearing anti-Chagas chemoprophylactic and therapeutical activities
    Patent number: 7521569
    Abstract: The invention refers to a process to obtain lignans, especially to obtain cubebin and methylpluviatolide from leaves of Zanthoxylum naranjillo or Piper cubeba. It also refers to a process to obtain semi-synthetic derivatives of cubebin, especially dibenzylbutirloactonic lignans, such as: hinokinin, o-acetyl cubebin, o-methyl cubebin, 6, 6?-dinitrohinokinin and o-dimethylethylamine cubebin and other derivatives which may be obtained, as well as to obtain methylpluviatolide derivatives, which are used to manufacture drugs to provide activity at least five times higher than observed for gentian violet and other compounds used heretofore for blood treatment and Chagas' disease prophylaxis.
    Type: Grant
    Filed: December 6, 2007
    Date of Patent: April 21, 2009
    Assignee: Fundação De Amparo À Pesquisa Do Estado de São Paulo
    Inventors: Marcio Luis Andrade Silva, Sergio Albuquerque, Gustavo Henrique Bianco Souza, Jairo Kenupp Bastos, Rosangela Silva
  • PROCESS TO OBTAIN DIBENZYLBUTYROLACTONIC LIGNANS, PROCESS TO OBTAIN SYNTHETIC DERIVATIVES FROM LIGNANS BEARING ANTI-CHAGAS CHEMOPROPHYLACTIC AND THERAPEUTICAL ACTIVITIES
    Publication number: 20080090901
    Abstract: The invention refers to a process to obtain lignans, especially to obtain cubebin and methylpluviatolide from leaves of Zanthoxylum naranjillo or Piper cubeba. It also refers to a process to obtain semi-synthetic derivatives of cubebin, especially dibenzylbutirloactonic lignans, such as: hinokinin, o-acetyl cubebin, o-methyl cubebin, 6,6?-dinitrohinokinin and o-dimethylethylamine cubebin and other derivatives which may be obtained, as well as to obtain methylpluviatolide derivatives, which are used to manufacture drugs to provide activity at least five times higher than observed for gentian violet and other compounds used heretofore for blood treatment and Chagas' disease prophylaxis.
    Type: Application
    Filed: December 6, 2007
    Publication date: April 17, 2008
    Applicant: Fundacao De Amparo A Pesquisa Do Estado de Sao Paulo
    Inventors: Marcio Luis Andrade SILVA, Sergio ALBUQUERQUE, Gustavo Henrique Bianco SOUZA, Jairo Kenupp BASTOS, Rosangela SILVA
  • Process to obtain dibenzylbutyrolactonic lignans, process to obtain synthetic derivatives from lignans bearing anti-Chagas chemoprophylactic and therapeutical activities
    Patent number: 7317114
    Abstract: The invention refers to a process to obtain lignans, especially to obtain cubebin and methylpluviatolide from leaves of Zanthoxylum naranjillo or Piper cubeba. It also refers to a process to obtain semi-synthetic derivatives of cubebin, especially dibenzylbutirloactonic lignans, such as: hinokinin, o-acetyl cubebin, o-methyl cubebin, 6,6?-dinitrohinokinine and o-dimethylethylamine cubebin and other derivatives which may be obtained, as well as to obtain methylpluviatolide derivatives, which are used to manufacture drugs to provide activity at least five times higher than observed for gentian violet and other compounds used heretofore for blood treatment and Chagas' disease prophylaxis.
    Type: Grant
    Filed: March 25, 2003
    Date of Patent: January 8, 2008
    Assignee: Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
    Inventors: Márcio Luis Andrade Silva, Sérgio Albuquerque, Gustavo Henrique Bianco Souza, Jairo Kenupp Bastos, Rosângela Silva