Patents by Inventor Mária José Illescas

Mária José Illescas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Consensus-based allele detection
    Patent number: 10851413
    Abstract: The present invention provides a method for genotyping alleles in at least one homologous genetic loci set, comprising: (i) providing a DNA-containing sample that includes said at least one homologous genetic loci set; (ii) performing PCR amplification of regions of said homologous genetic loci set using consensus sequence-specific primers, wherein said consensus sequence-specific primers bind to consensus sequences that are common to a plurality of genes within the genetic loci set, thereby generating a pool of amplification products; (iii) sequencing a plurality of said amplification products in order to determine the relative proportion of each nucleotide at each position in a sequencing read; (iv) performing a sequence alignment between the sequencing read results of (iii) and at least one reference sequence, which reference sequence corresponds to one of the genes in said homologous genetic loci set; and (v) performing genotype calling of the allele or alleles in said sample based on the relative proport
    Type: Grant
    Filed: August 12, 2015
    Date of Patent: December 1, 2020
    Assignee: Progenika Biopharma S.A.
    Inventors: Jorge Ochoa, David Arteta, Mariá José Illescas, Monica Lopez, Marianne Stef, Diego Tejedor, Antonio Martìnez
  • CONSENSUS-BASED ALLELE DETECTION
    Publication number: 20180305756
    Abstract: The present invention provides a method for genotyping alleles in at least one homologous genetic loci set, comprising: (i) providing a DNA-containing sample that includes said at least one homologous genetic loci set; (ii) performing PCR amplification of regions of said homologous genetic loci set using consensus sequence-specific primers, wherein said consensus sequence-specific primers bind to consensus sequences that are common to a plurality of genes within the genetic loci set, thereby generating a pool of amplification products; (iii) sequencing a plurality of said amplification products in order to determine the relative proportion of each nucleotide at each position in a sequencing read; (iv) performing a sequence alignment between the sequencing read results of (iii) and at least one reference sequence, which reference sequence corresponds to one of the genes in said homologous genetic loci set; and (v) performing genotype calling of the allele or alleles in said sample based on the relative proport
    Type: Application
    Filed: August 12, 2015
    Publication date: October 25, 2018
    Applicant: Progenika Biopharma S.A.
    Inventors: Jorge Ochoa, David Arteta, Mária José Illescas, Monica Lopez, Marianne Stef, Diego Tejedor, Antonio Martínez