Abstract: A knitted component for an article of footwear may have an overfoot portion and an underfoot portion, a first yarn, where the first yarn at least partially forms the overfoot portion and at least partially forms the underfoot portion, and a second yarn, where the second yarn at least partially forms the overfoot portion and at least partially forms the underfoot portion. The first yarn may include a first material composition with a first melting point and the second yarn may include a second material composition with a second melting point. The first melting point may be at least 20 degrees Celsius higher than the second melting point.

Abstract: The invention is directed to compounds of Formula I: wherein A, X, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairy cell leukemia and non-small lung carcinoma; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including arthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.