Abstract: The present invention thus provides a simple and automatic method for determining an optimal AV interval and/or range of AV intervals for, in an exemplary embodiment, LV-only pacing. Such a method provides significant advantages for patients while reducing burdens related to post-implant follow-up by clinicians in that it greatly reduces the need for doing echocardiographic-based AV interval optimization procedures as well as providing a way to dynamically optimize AV intervals as the patient moves about their activities of daily living (ADL).

Abstract: The present invention enables efficient provision of hemodynamic benefits and therapy for patients suffering from intraventricular conduction delays or conduction blockage. The invention enables effectively measures against conduction delay or block (e.g., left bundle branch block or “LBBB”) and enhances delivery of a novel form of left ventricle-only cardiac resynchronization therapy. According to the invention, a single LV fusion pacing stimulus is triggered from an atrial event (e.g., intrinsic or evoked depolarization). The triggering event can emanate from the right atrium (RA) or the left atrium (LA). The single LV fusion pacing stimulus is delivered prior to the intrinsic depolarization of the RV—upon expiration of a “LEPARS interval”—thus efficiently providing intraventricular electromechanical synchrony by fusion.