Patents by Inventor M. Selim Ünlü
M. Selim Ünlü has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240036339Abstract: An exemplary illumination source is provided. The illumination source includes a light integrating device for coupling to at least one optical structure at an output port. The light integrating device includes at least one input port. At least one light source produces at least one optical illumination coupled to the at least one input port. A light adjusting tool controls the optical illumination emitted by the light integrating device. The light adjusting tool controls uniformity of light emitted by the light integrating device by modifying at least one internal surface of the light integrating device.Type: ApplicationFiled: July 26, 2023Publication date: February 1, 2024Applicant: Trustees of Boston UniversityInventors: M. Selim Ünlü, Mete Aslan, Iris Celebi, Celalettin Yurdakul, Allison Marie Marn
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Publication number: 20230408805Abstract: Microscopic analysis of a sample includes a system using dark-field illumination. A mid-IR optical source generates a mid-infrared beam, which is directed onto the sample to induce a temperature change by absorption of the mid-infrared beam. A visible light source generates a light illuminating the sample on a substrate and creating a scattered field and a reflected field along a collection path of the system. A pupil mask is positioned along the collection path to block the reflected field while allowing the scattered field to pass therethrough. A camera is positioned at an end of the collection path to collect the scattered field and generate a dark-field image of the sample.Type: ApplicationFiled: June 2, 2023Publication date: December 21, 2023Applicant: Trustees of Boston UniversityInventors: Ji-Xin Cheng, Celalettin Yurdakul, Haonan Zong, M. Selim Ünlü
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Patent number: 11709352Abstract: Microscopic analysis of a sample includes a system using dark-field illumination. A mid-IR optical source generates a mid-infrared beam, which is directed onto the sample to induce a temperature change by absorption of the mid-infrared beam. A visible light source generates a light illuminating the sample on a substrate and creating a scattered field and a reflected field along a collection path of the system. A pupil mask is positioned along the collection path to block the reflected field while allowing the scattered field to pass therethrough. A camera is positioned at an end of the collection path to collect the scattered field and generate a dark-field image of the sample.Type: GrantFiled: March 25, 2022Date of Patent: July 25, 2023Assignee: Trustees of Boston UniversityInventors: Ji-Xin Cheng, Celalettin Yurdakul, Haonan Zong, M. Selim Ünlü
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Publication number: 20230116588Abstract: Herein is described kinetic assay, in which individual binding events are detected and monitored during sample incubation. This method uses interferometric reflectance imaging to detect thousands of individual binding events across a multiplex solid phase sensor with a large area. A dynamic tracking procedure is used to measure the duration of each event. From this, the total rates of binding and de-binding as well as the distribution of binding event durations are determined. Systems and components for performing the kinetic assay are also described.Type: ApplicationFiled: December 7, 2022Publication date: April 13, 2023Applicant: Trustees of Boston UniversityInventors: Derin Sevenler, M. Selim Ünlü
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Patent number: 11573177Abstract: Provided herein are methods for capturing extracellular vesicles from a biological sample for quantification and/or characterization (e.g., size and/or shape discrimination) using an SP-IRIS system. Also provided herein are methods of detecting a biomarker on captured extracellular vesicles or inside the captured vesicles (e.g., intra-vesicular or intra-exosomal biomarkers).Type: GrantFiled: January 14, 2021Date of Patent: February 7, 2023Assignee: TRUSTEES OF BOSTON UNIVERSITYInventors: M. Selim Ünlü, George G. Daaboul, Marcella Chiari
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Patent number: 11561221Abstract: Herein is described kinetic assay, in which individual binding events are detected and monitored during sample incubation. This method uses interferometric reflectance imaging to detect thousands of individual binding events across a multiplex solid phase sensor with a large area. A dynamic tracking procedure is used to measure the duration of each event. From this, the total rates of binding and de-binding as well as the distribution of binding event durations are determined. Systems and components for performing the kinetic assay are also described.Type: GrantFiled: May 2, 2019Date of Patent: January 24, 2023Assignee: TRUSTEES OF BOSTON UNIVERSITYInventors: Derin Sevenler, M. Selim Ünlü
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Patent number: 11428626Abstract: An imaging system uses polarized light to illuminate the target and then uses a polarization filter to remove the light that is reflected from the target without modification. The target can include one or more anisotropic objects that scatter the light and alter the polarization state of the reflected light and causing it to be selectively transmitted to the imaging device which can record the transmitted light through the filter. The illuminating light can be circularly polarized and the filter can remove the circularly polarized light. The target can include asymmetric nanoparticles, such as nanorods that alter the amplitude or phase of the scattered light enabling pass through the filter to be detected by the imaging device.Type: GrantFiled: October 18, 2019Date of Patent: August 30, 2022Assignee: TRUSTEES OF BOSTON UNIVERSITYInventors: M. Selim Ünlü, George Daaboul, Abdulkadir Yurt
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Patent number: 11137343Abstract: An apparatus, and method of operating the same, detects changes in biomass accumulating on a surface of a substrate while minimizing bulk effect. The apparatus includes a sensor substrate and two illumination sources. A first illumination source generates a first light having a first central wavelength. A second illumination source generates a second light having a second central wavelength different than the first wavelength. The first and second light are mixed to produce a combined light. An analyte solution is introduced to the sensor substrate. Incident light of the combined light is reflected from the sensor substrate to produce a signal. The signal is imaged with a camera to obtain a reflectance. Reflectance produced by the combined light is not affected by variations in the dielectric properties of the analyte solution. A biomass accumulated on the substrate is computed based on the reflectance.Type: GrantFiled: December 8, 2020Date of Patent: October 5, 2021Assignee: TRUSTEES OF BOSTON UNIVERSITYInventors: M. Selim Ünlü, Celalettin Yurdakul, Allison Marie Marn
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Publication number: 20210231563Abstract: Provided herein are methods for capturing extracellular vesicles from a biological sample for quantification and/or characterization (e.g., size and/or shape discrimination) using an SP-IRIS system. Also provided herein are methods of detecting a biomarker on captured extracellular vesicles or inside the captured vesicles (e.g., intra-vesicular or intra-exosomal biomarkers).Type: ApplicationFiled: January 14, 2021Publication date: July 29, 2021Applicant: TRUSTEES OF BOSTON UNIVERSITYInventors: M. Selim ÜNLÜ, George G. Daaboul, Marcella Chiari
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Publication number: 20210172863Abstract: An apparatus, and method of operating the same, detects changes in biomass accumulating on a surface of a substrate while minimizing bulk effect. The apparatus includes a sensor substrate and two illumination sources. A first illumination source generates a first light having a first central wavelength. A second illumination source generates a second light having a second central wavelength different than the first wavelength. The first and second light are mixed to produce a combined light. An analyte solution is introduced to the sensor substrate. Incident light of the combined light is reflected from the sensor substrate to produce a signal. The signal is imaged with a camera to obtain a reflectance. Reflectance produced by the combined light is not affected by variations in the dielectric properties of the analyte solution. A biomass accumulated on the substrate is computed based on the reflectance.Type: ApplicationFiled: December 8, 2020Publication date: June 10, 2021Applicant: Trustees of Boston UniversityInventors: M. Selim Ünlü, Celalettin Yurdakul, Allison Marie Marn
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Publication number: 20210069706Abstract: A low cost/disposable fluidic cartridge for interferometric reflectance imaging sensor is described. Systems and methods using this cartridge are also disclosed. The cartridges and systems simplify the protocols and minimizes potential user error, for example, in biosensing experiments and assays.Type: ApplicationFiled: December 11, 2018Publication date: March 11, 2021Applicant: TRUSTEES OF BOSTON UNIVERSITYInventors: M. Selim ÜNLÜ, Derin SEVENLER, Jabob TRUEB, Steven SCHERR
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Patent number: 10705138Abstract: A device testing approach employs optical antennas at test locations of a semiconductor device, usable as either/both radiators or receivers. As a radiator, an antenna responds to localized optical energy at a test location of the device to generate corresponding radiated optical energy that can be sensed and processed by a test system. As a receiver, an antenna receives radiated optical energy as generated by a test system and converts the energy into corresponding localized optical energy for affecting operation of the device. The optical antennas may be formed from metal segments on the same metal layers used for signal interconnections in the device, and thus the disclosed approach can provide enhanced test functionality without burdening the device manufacturing process with additional complexity solely to support testing. The testing approach may be used in different modalities in which the antennas variably act as transmitters, receivers, and reflectors/refractors.Type: GrantFiled: July 6, 2016Date of Patent: July 7, 2020Assignee: Trustees of Boston UniversityInventors: M. Selim Ünlü, Bennett B. Goldberg, Yusuf Leblebici
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Publication number: 20200150028Abstract: An imaging system uses polarized light to illuminate the target and then uses a polarization filter to remove the light that is reflected from the target without modification. The target can include one or more anisotropic objects that scatter the light and alter the polarization state of the reflected light and causing it to be selectively transmitted to the imaging device which can record the transmitted light through the filter. The illuminating light can be circularly polarized and the filter can remove the circularly polarized light. The target can include asymmetric nanoparticles, such as nanorods that alter the amplitude or phase of the scattered light enabling pass through the filter to be detected by the imaging device.Type: ApplicationFiled: October 18, 2019Publication date: May 14, 2020Applicant: TRUSTEES OF BOSTON UNIVERSITYInventors: M. Selim ÜNLÜ, George DAABOUL, Abdulkadir YURT
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Patent number: 10585042Abstract: A system for analyzing one or more liquid samples includes a microwell plate including a plurality of rows of wells configured to store liquid samples, a sensor array that is moveable relative to the microwell plate along a first axis between a first position and a second position to allow a portion of the sensor array to be disposed within a first one of the plurality of rows of wells when the sensor array is in the second position, an objective, and one or more linear translation stages configured to move the microwell plate relative to the objective (i) along a second axis that is orthogonal to the first axis, (ii) along a third axis that is orthogonal to the first axis and the second axis, or (iii) both (i) and (ii).Type: GrantFiled: June 5, 2019Date of Patent: March 10, 2020Assignees: TRUSTEES OF BOSTON UNIVERSITY, NANOVIEW BIOSCIENCES, INC.Inventors: M. Selim Ünlü, Derin Sevenler, Jacob Trueb, Oguzhan Avci, Celalettin Yurdakul, Steven Scherr, George G. Daaboul, David S. Freedman
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Publication number: 20190376896Abstract: A system for analyzing one or more liquid samples includes a microwell plate including a plurality of rows of wells configured to store liquid samples, a sensor array that is moveable relative to the microwell plate along a first axis between a first position and a second position to allow a portion of the sensor array to be disposed within a first one of the plurality of rows of wells when the sensor array is in the second position, an objective, and one or more linear translation stages configured to move the microwell plate relative to the objective (i) along a second axis that is orthogonal to the first axis, (ii) along a third axis that is orthogonal to the first axis and the second axis, or (iii) both (i) and (ii).Type: ApplicationFiled: June 5, 2019Publication date: December 12, 2019Inventors: M. SELIM ÜNLÜ, DERIN SEVENLER, JACOB TRUEB, OGUZHAN AVCI, CELALETTIN YURDAKUL, STEVEN SCHERR, GEORGE G. DAABOUL, DAVID S. FREEDMAN
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Patent number: 10488328Abstract: An imaging system uses polarized light to illuminate the target and then uses a polarization filter to remove the light that is reflected from the target without modification. The target can include one or more anisotropic objects that scatter the light and alter the polarization state of the reflected light and causing it to be selectively transmitted to the imaging device which can record the transmitted light through the filter. The illuminating light can be circularly polarized and the filter can remove the circularly polarized light. The target can include asymmetric nanoparticles, such as nanorods that alter the amplitude or phase of the scattered light enabling pass through the filter to be detected by the imaging device.Type: GrantFiled: March 6, 2015Date of Patent: November 26, 2019Assignee: TRUSTEES OF BOSTON UNIVERSITYInventors: M. Selim Ünlü, George Daaboul, Abdulkadir Yurt
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Publication number: 20190339268Abstract: Herein is described kinetic assay, in which individual binding events are detected and monitored during sample incubation. This method uses interferometric reflectance imaging to detect thousands of individual binding events across a multiplex solid phase sensor with a large area. A dynamic tracking procedure is used to measure the duration of each event. From this, the total rates of binding and de-binding as well as the distribution of binding event durations are determined. Systems and components for performing the kinetic assay are also described.Type: ApplicationFiled: May 2, 2019Publication date: November 7, 2019Applicant: Trustees of Boston UniversityInventors: Derin Sevenler, M. Selim Ünlü
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Publication number: 20160313395Abstract: A device testing approach employs optical antennas at test locations of a semiconductor device, usable as either/both radiators or receivers. As a radiator, an antenna responds to localized optical energy at a test location of the device to generate corresponding radiated optical energy that can be sensed and processed by a test system. As a receiver, an antenna receives radiated optical energy as generated by a test system and converts the energy into corresponding localized optical energy for affecting operation of the device. The optical antennas may be formed from metal segments on the same metal layers used for signal interconnections in the device, and thus the disclosed approach can provide enhanced test functionality without burdening the device manufacturing process with additional complexity solely to support testing. The testing approach may be used in different modalities in which the antennas variably act as transmitters, receivers, and reflectors/refractors.Type: ApplicationFiled: July 6, 2016Publication date: October 27, 2016Inventors: M. Selim Ünlü, Bennett B. Goldberg, Yusuf Leblebici