Patents by Inventor M. Teresa Yip

M. Teresa Yip has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5258311
    Abstract: Use of a lithium salt, particularly lithium thiocyanate, as an agent for lysing red blood cells and denaturing hemoglobin in the performance of an immunoassay to detect the relative amount of a hemoglobin derivative in a blood sample. The method is particularly useful in the determination of hemoglobin Alc. The method provides a rapid means for releasing hemoglobin from red blood cells by lysis and for exposing the epitope that is characteristic of the Alc form. Low concentrations of the lithium salt provide rapid release and denaturation of hemoglobin without the need for dilution prior to the performance of the immunoassay.
    Type: Grant
    Filed: March 30, 1992
    Date of Patent: November 2, 1993
    Assignee: Miles Inc.
    Inventors: Lynette A. Lewis, M. Teresa Yip
  • Patent number: 5191073
    Abstract: Chromogenic merocyanine enzyme substrate compounds of the general formula: ##STR1## where Y is an enzymatically-cleavable group such as a radical of a sugar, carboxylic acid, amino acid, peptide, phosphoric acid, or sulfuric acid; A and B represent residues that complete 5- or 6-membered ring systems; R.sup.1 is substituted or unsubstituted alkyl; R.sup.2 and R.sup.3, independently, are hydrogen or lower alkyl; m, n, and p, which can be different, are integers from 0 through 3 provided that m+n+p must be at least 2; and X is an appropriate counterion (anion).
    Type: Grant
    Filed: February 26, 1992
    Date of Patent: March 2, 1993
    Assignee: Miles Inc.
    Inventors: Paul F. Corey, M. Teresa Yip
  • Patent number: 5151369
    Abstract: Use of a lithium salt, particularly lithium thiocyanate, as an agent for lysing red blood cells and denaturing hemoglobin in the performance of an immunoassay to detect the relative amount of a hemoglobin derivative in a blood sample. The method is particularly useful in the determination of hemoglobin A1c. The method rapidly releases hemoglobin from red blood cells by lysis and exposes the epitope that is characteristic of the A1c form. Low concentrations of the lithium salt provide rapid release and denaturation of hemoglobin without the need for dilution prior to the performance of the immunoassay.
    Type: Grant
    Filed: May 14, 1990
    Date of Patent: September 29, 1992
    Assignee: Miles Inc.
    Inventors: Lynette A. Lewis, M. Teresa Yip
  • Patent number: 5122602
    Abstract: Chromogenic merocyanine enzyme substrate compounds of the general formula: ##STR1## where Y is an enzymatically-cleavable group such as a radical of a sugar, carboxylic acid, amino acid, peptide, phosphoric acid, or sulfuric acid; A and B represent residues that complete 5- or 6-membered ring systems; R.sup.1 is substituted or unsubstituted alkyl; R.sup.2 and R.sup.3, independently, are hydrogen or lower alkyl; m, n, and p, which can be different, are integers from 0 through 3 provided that m+n+p must be at least 2; and X is an appropriate counterion (anion).
    Type: Grant
    Filed: February 13, 1989
    Date of Patent: June 16, 1992
    Assignee: Miles Inc.
    Inventors: Paul F. Corey, M. Teresa Yip