Patents by Inventor M. Uljana Mayer-Cumblidge

M. Uljana Mayer-Cumblidge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyanine-based probe\tag-peptide pair fluorescence protein imaging and fluorescence protein imaging methods
    Patent number: 8354499
    Abstract: A molecular probe comprises two arsenic atoms and at least one cyanine based moiety. A method of producing a molecular probe includes providing a molecule having a first formula, treating the molecule with HgOAc, and subsequently transmetallizing with AsCl3. The As is liganded to ethanedithiol to produce a probe having a second formula. A method of labeling a peptide includes providing a peptide comprising a tag sequence and contacting the peptide with a biarsenical molecular probe. A complex is formed comprising the tag sequence and the molecular probe. A method of studying a peptide includes providing a mixture containing a peptide comprising a peptide tag sequence, adding a biarsenical probe to the mixture, and monitoring the fluorescence of the mixture.
    Type: Grant
    Filed: May 4, 2010
    Date of Patent: January 15, 2013
    Assignee: Battelle Memorial Institute
    Inventors: M. Uljana Mayer-Cumblidge, Haishi Cao
  • Cyanine-Based Probe\Tag-Peptide Pair Fluorescence Protein Imaging and Fluorescence Protein Imaging Methods
    Publication number: 20100216182
    Abstract: A molecular probe comprises two arsenic atoms and at least one cyanine based moiety. A method of producing a molecular probe includes providing a molecule having a first formula, treating the molecule with HgOAc, and subsequently transmetallizing with AsCl3. The As is liganded to ethanedithiol to produce a probe having a second formula. A method of labeling a peptide includes providing a peptide comprising a tag sequence and contacting the peptide with a biarsenical molecular probe. A complex is formed comprising the tag sequence and the molecular probe. A method of studying a peptide includes providing a mixture containing a peptide comprising a peptide tag sequence, adding a biarsenical probe to the mixture, and monitoring the fluorescence of the mixture.
    Type: Application
    Filed: May 4, 2010
    Publication date: August 26, 2010
    Applicant: BATTELLE MEMORIAL INSTITUTE
    Inventors: M. Uljana Mayer-Cumblidge, Haishi Cao
  • Cyanine-based probe\tag-peptide pair for fluorescence protein imaging and fluorescence protein imaging methods
    Patent number: 7776999
    Abstract: A molecular probe comprises two arsenic atoms and at least one cyanine based moiety. A method of producing a molecular probe includes providing a molecule having a first formula, treating the molecule with HgOAc, and subsequently transmetallizing with AsCl3. The As is liganded to ethanedithiol to produce a probe having a second formula. A method of labeling a peptide includes providing a peptide comprising a tag sequence and contacting the peptide with a biarsenical molecular probe. A complex is formed comprising the tag sequence and the molecular probe. A method of studying a peptide includes providing a mixture containing a peptide comprising a peptide tag sequence, adding a biarsenical probe to the mixture, and monitoring the fluorescence of the mixture.
    Type: Grant
    Filed: April 12, 2007
    Date of Patent: August 17, 2010
    Assignee: Battelle Memorial Institute
    Inventors: M. Uljana Mayer-Cumblidge, Haishi Cao
  • A Cyanine-based probe\tag-peptide pair for fluorescence protein imaging and fluorescence protein imaging methods
    Publication number: 20080254546
    Abstract: A molecular probe comprises two arsenic atoms and at least one cyanine based moiety. A method of producing a molecular probe includes providing a molecule having a first formula, treating the molecule with HgOAc, and subsequently transmetallizing with AsCl3. The As is liganded to ethanedithiol to produce a probe having a second formula. A method of labeling a peptide includes providing a peptide comprising a tag sequence and contacting the peptide with a biarsenical molecular probe. A complex is formed comprising the tag sequence and the molecular probe. A method of studying a peptide includes providing a mixture containing a peptide comprising a peptide tag sequence, adding a biarsenical probe to the mixture, and monitoring the fluorescence of the mixture.
    Type: Application
    Filed: April 12, 2007
    Publication date: October 16, 2008
    Inventors: M. Uljana Mayer-Cumblidge, Haishi Cao