Abstract: Provided herein are methods for treating a virus (e.g,. an RNA virus, such as a SARS-CoV-2) infection or a disease associated therewith (e.g., COVID-19) comprising administering a compound of Formula (I), or a salt thereof, or a composition thereof to a subject (e.g., a human subject). Also provided herein are methods for treating a virus (e.g,. an RNA virus, such as a SARS-CoV-2) infection or a disease associated therewith (e.g., COVID-19) comprising administering 108110 or a composition thereof to a subject (e.g., a human subject). In addition, provided herein are methods for treating a virus (e.g., an RNA virus, such as a SARS-CoV-2) infection or a disease associated therewith (e.g., COVID-19) comprising administering 108600 or a composition thereof to a subject (e.g., a human subject).

Abstract: A computer implemented method of video data encoding generates a mask having one bit corresponding each spatial frequency coefficient of a block during quantization. The bit state of the mask depends upon whether the corresponding quantized spatial frequency coefficient is zero or non-zero. The runs of zero quantized spatial frequency coefficients determined by a left most bit detect instruction are determined from the mask and run length encoded. The mask is generated using a look up table to map the scan order of quantization to the zig-zag order of run length encoding. Variable length coding and inverse quantization optionally take place within the run length encoding loop.

Abstract: This invention is useful in video compression standards support a rich set of intra prediction modes. This invention a unique table creation and lookup approach to software pipeline the prediction process for all pixels within a block. The table stores constant data and pointer data into a neighbor pixel table. Indexing into the table based upon the current intra prediction mode for each pixel of a block recalls constant data and other pixel data for calculation of an intra prediction value.

Abstract: A half sample and quarter sample pixel value interpolation calculation classifies a set of all possible half sample and quarter sample pixel value interpolation calculations into a plurality of interpolation types. A function kernel for each interpolation type includes a half sample pixel and all quarter sample pixels whose value calculation depend on a value of said half sample pixel value. The correct function kernel is called invoking the corresponding value interpolation calculation. The function kernels operate iteratively over a plurality of macroblocks of at least two macroblock sub-partition sizes. The calculation of dependent quarter sample pixel values preferably employs a packed average instruction.

Abstract: This invention is useful in video compression standards support a rich set of intra prediction modes. This invention a unique table creation and lookup approach to software pipeline the prediction process for all pixels within a block. The table stores constant data and pointer data into a neighbor pixel table. Indexing into the table based upon the current intra prediction mode for each pixel of a block recalls constant data and other pixel data for calculation of an intra prediction value.

Abstract: ?,?-Unsaturated sulfones, sulfoxides, sulfonimides, sulfinimides, acylsulfonamides and acylsulfinamides of Formula I: wherein R1, R2, M1, M2, L, E1, E2, Q1, Q2 and n are as defined herein, are useful as anti-angiogenesis agents, as agents for treatment of age related senile dementia, and as antiproliferative agents including, for example, as anticancer agents.

Abstract: A computer implemented method of video date encoding generates a mask having one bit corresponding each spatial frequency coefficient of a block during quantization. The bit state of the mask depends upon whether the corresponding quantized spatial frequency coefficient is zero or non-zero. The runs of zero quantized spatial frequency coefficients determined by a left most bit detect instruction are determined from the mask and run length encoded. The mask is generated using a look up table to map the scan order of quantization to the zig-zag order of run length encoding. Variable length coding and inverse quantization optionally take place within the run length encoding loop.

Abstract: Compounds of Formula I: wherein R1, R2, M, Q and n are as defined herein, are useful as antiproliferative agents including, for example, as anticancer agents.

Abstract: ??-Unsaturated sulfoxides of Formula I: are useful as antiproliferative agents including, for example, anticancer agents, and as radioprotective and chemoprotective agents.

Abstract: Compounds useful as antiproliferative agents, radioprotective agents and cytoprotective agents, including, for example, anticancer agents, are provided according to formula I: wherein ring A, ring B,,X, R1, R2, R3, a, and b are as defined herein.

Abstract: Provided are processes and chemical intermediates useful for preparing a compound of the formula I wherein X is selected from the group consisting of C1-C6 trihalomethyl; C1-C6 alkyl; and an optionally substituted or di-substituted phenyl group of formula II: Y and Z are independently selected from the group consisting of substituted and unsubstituted aryl.

Abstract: Provided are compounds, processes and synthetic intermediates useful for the preparation of compounds of the formula I and IX wherein R1 is selected from the group consisting of hydrogen, trihalomethyl, C1-C6 alkyl and substituted or unsubstituted phenyl; Y is a group of the formula wherein R2 is selected from the group consisting of C1-C6 alkyl, C1-C6 alkanoylamino and amino; and R5 is selected from the group consisting of hydrogen, amino, halogen, hydroxyl, nitro, C1-C6 alkyl, C1-C6 alkoxy, carboxy, C1-C6 trihaloalkyl, cyano, phosphonato, and hydroxyalkyl; and Z is selected from the group consisting of substituted and unsubstituted aryl. Also provided are certain N-acylated analogs of compounds of the formula I and IX, and processes for their preparation.

Abstract: Compounds useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula (I); wherein: X, X1, X2, Ra, R1, R2,R3, R4, R5, R6, R7, g, M, y, a, b, d, e, V, W, Z and Q are as defined herein.

Abstract: (E)-Styryl benzylsulfones useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula I: wherein: R1 is selected from the group consisting of halogen, C1-C6 alkoxy, nitro, phosphonato, amino, sulfamyl, carboxy, acetoxy and dimethylamino (C2-C6 alkoxy); and R2 and R3 are independently selected from the group consisting of halogen, C1-C6 alkoxy, C1-C6 alkyl, nitro, cyano, hydroxyl, phosphonato, amino, sulfamyl, carboxy, acetoxy, and dimethylamino (C2-C6 alkoxy); provided: R1 may not be halogen when R2 and R3 are both halogen; R2 may not be 2-halogen when R3 is 4-halogen; or a pharmaceutically acceptable salt thereof; or formula II: wherein: R4 is selected from the group consisting of C1-C6 alkoxy, phosphonato, amino, sulfamyl, carboxy, acetoxy and dimethylamino (C2-C6 alkoxy); R6 is selected from the group consisting of nitro, hydrogen, phosphonato, amino, sulfamyl, carboxy, acetoxy and dimethylamino (C2-C6 alkoxy); and R7 is selected from the group consistin

Abstract: Compounds useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula I: wherein: Ar, X, X1, g, R and R3 are as defined herein.