Abstract: The present invention provides methods and compositions for treating cancer, and even more preferably, prostate cancer. In one aspect, the present invention comprises a method for inducing cell death in cancer cells comprising treating at least a portion of the cancer cells with an effective amount of TRAIL and an effective amount of an antiprogestin sufficient to induce apoptosis in at least a portion of the treated cancer cells. In another aspect, the present invention comprises a composition for treating cancer by inducing cell death in cancer cells comprising a pharmaceutical composition comprising an effective amount of TRAIL and an effective amount of an antiprogestin sufficient to induce apoptosis in at least a portion of the cancer cells exposed to the composition. In an embodiment, the antiprogestin is Mifepristone.