Patents by Inventor Maïa CHANRION

Maïa CHANRION has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MCL-1 INHIBITOR ANTIBODY-DRUG CONJUGATES AND METHODS OF USE
    Publication number: 20230092679
    Abstract: Antibody-drug conjugates that bind to human oncology targets are disclosed. The antibody-drug conjugates comprise an Mcl-1 inhibitor drug moiety. The disclosure further relates to methods and compositions for use in the treatment of cancers by administering the antibody-drug conjugates provided herein. Linker-drug conjugates comprising an Mcl-1 inhibitor drug moiety and methods of making same are also disclosed.
    Type: Application
    Filed: May 19, 2020
    Publication date: March 23, 2023
    Inventors: Matthew T. Burger, Maia Chanrion, Frédéric Colland, Marton Csekei, Lea Delacour, Patrice Desos, Olivier Geneste, Jean-Michel Henlin, Vesela Kostova, Andras Kotschy, Ana Leticia Maragno, Eric McNeill, Mark G. Palermo, Francesca Rocchetti, Jérôme Starck, Bing Yu, Qiang Zhang, Ágnes Proszenyák, Szabolcs Sipos, Zhuoliang Chen, Katsumasa Nakajima, Joseph Anthony D'Alessio
  • MCL-1 INHIBITOR ANTIBODY-DRUG CONJUGATES AND METHODS OF USE
    Publication number: 20230081720
    Abstract: Anti-CD74 antibody-drug conjugates are disclosed. The anti-CD74 antibody-drug conjugates comprise an Mcl-1 inhibitor drug moiety and an anti-CD74 antibody or antigen-binding fragment thereof that binds an antigen target, e.g., an antigen expressed on a tumor or other cancer cell. The disclosure further relates to methods and compositions for use in the treatment of cancers by administering the antibody-drug conjugates provided herein. Linker-drug conjugates comprising an Mcl-1 inhibitor drug moiety and methods of making same are also disclosed.
    Type: Application
    Filed: May 19, 2020
    Publication date: March 16, 2023
    Inventors: Matthew T. Burger, Maia Chanrion, Frédéric Colland, Marton Csekei, Lea Delacour, Patrice Desos, Olivier Geneste, Jean-Michel Henlin, Vesela Kostova, Andras Kotschy, Ana Leticia Maragno, Eric McNeill, Mark G. Palermo, Francesca Rocchetti, Jérôme Starck, Bing Yu, Qiang Zhang, Ágnes Proszenyák, Szabolcs Sipos, Zhuoliang Chen, Katsumasa Nakajima, Joseph Anthony D'Alessio, John William Blankenship
  • 6,7-DIHYDRO-5H-PYRIDO[2,3-C]PYRIDAZINE DERIVATIVES AND RELATED COMPOUNDS AS BCL-XL PROTEIN INHIBITORS AND PRO-APOPTOTIC AGENTS FOR TREATING CANCER
    Publication number: 20220363677
    Abstract: Compounds of formula (I): wherein Het, Het1, Het2, A4, A5, Z1, R1, R2 and R3 are as defined in the description. Medicaments.
    Type: Application
    Filed: July 28, 2020
    Publication date: November 17, 2022
    Inventors: Tibor NOVÁK, James Edward Paul DAVIDSON, Attila PACZAL, Jérôme-Benoît STARCK, András KOTSCHY, James Brooke MURRAY, Simon BEDFORD, Maïa CHANRION, Frédéric COLLAND, Mark Philip DODSWORTH, Andràs HERNER, Ana Leticia MARAGNO, Emma SANDERS, Mátyás Pál TIMÁRI, Paul WEBB
  • 3,6-DIAMINO-PYRIDAZIN-3-YL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS PRO-APOPTOTIC AGENTS
    Publication number: 20220289734
    Abstract: Compounds of formula (I): wherein Het1, Het2, R1, R2 and R3 are as defined in the description.
    Type: Application
    Filed: July 28, 2020
    Publication date: September 15, 2022
    Inventors: James Edward Paul DAVIDSON, Tibor NOVÁK, Attila PACZAL, András KOTSCHY, Jérôme-Benoît STARCK, James Brooke MURRAY, Simon BEDFORD, Maïa CHANRION, Frédéric COLLAND, Patrice DESOS, Mark Philip DODSWORTH, Petra DUNKEL, Andràs HERNER, Zoltán MADARÁSZ, Ana Leticia MARAGNO, Márk MOLNÁR, Miklós NYERGES, Rachel Jane PARSONS, Monika RUDASOVÁ, Ágnes STROFEK, Marianna SZIGETI, Mátyás Pál TIMÁRI, Paul WEBB
  • Substituted piperidines as inhibitors of ubiquitin specific protease 7
    Patent number: 11332472
    Abstract: Compounds of formula (I): wherein R1, R2, R3, B, W, Z, m and n are as defined in the description.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: May 17, 2022
    Assignees: LES LABORATOIRES SERVIER, VERNALIS (R&D) LTD
    Inventors: András Kotschy, Csaba Wéber, Attila Vasas, Árpád Kiss, Balázs Molnár, Ágnes Strofek, Vilibald Kun, James Brooke Murray, Alba Macias, Elodie Lewkowicz, Maïa Chanrion, Lisa Ivanschitz, Olivier Geneste
  • CYCLODEXTRIN-BASED FORMULATION OF A BCL-2 INHIBITOR
    Publication number: 20210353633
    Abstract: The invention relates to a pharmaceutical composition comprising 5-(5-chloro-2-{[(3S)-3-(morpholin-4-ylmethyl)-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl} phenyl)-N-(5-cyano-1,2-dimethyl-1H-pyrrol-3-yl)-N-(4-hydroxyphenyl)-1,2-dimethyl-1H-pyrrole-3-carboxamide, referred to herein as ‘Compound A’, or a pharmaceutically acceptable salt thereof, and a cyclodextrin. More specifically, the invention relates to a solid pharmaceutical composition comprising Compound A and a cyclodextrin, and a pharmaceutical composition for parenteral administration prepared by dissolving this solid pharmaceutical composition. Furthermore, the invention relates to the use of such compositions for the treatment of cancer.
    Type: Application
    Filed: October 30, 2019
    Publication date: November 18, 2021
    Inventors: Caroline CHEMIN, Thuy TRAN THU, Jean-Manuel PEAN, Maia CHANRION
  • Substituted piperidines for the treatment of cancer
    Patent number: 11046681
    Abstract: Compounds of formula (I): wherein R1, R2, R3, n and W are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring pro-apoptotic and/or anti-proliferative agents.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: June 29, 2021
    Assignees: LES LABORATOIRES SERVIER, VERNALIS (R&D) LTD
    Inventors: András Kotschy, Csaba Wéber, Attila Vasas, Balázs Molnár, Árpád Kiss, Alba Macias, James Brooke Murray, Elodie Lewkowicz, Olivier Geneste, Maïa Chanrion, Didier Demarles
  • NEW PIPERIDINYL DERIVATIVES AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7
    Publication number: 20200407363
    Abstract: Compounds of formula (I): wherein R1, R2, R3, B, W, Z, m and n are as defined in the description.
    Type: Application
    Filed: November 28, 2018
    Publication date: December 31, 2020
    Inventors: András KOTSCHY, Csaba WÉBER, Attila VASAS, Árpád KISS, Balázs MOLNÁR, Ágnes STROFEK, Vilibald KUN, James Brooke MURRAY, Alba MACIAS, Elodie LEWKOWICZ, Maïa CHANRION, Lisa IVANSCHITZ, Olivier GENESTE
  • Combination of a MCL-1 inhibitor and a taxane compound, uses and pharmaceutical compositions thereof
    Patent number: 10765680
    Abstract: A combination comprising a MCL-1 inhibitor and a taxane compound, and compositions and uses thereof.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: September 8, 2020
    Assignees: LES LABORATORIES SERVIER, NOVARTIS AG
    Inventors: Dale Porter, Ensar Halilovic, Maïa Chanrion, Ana Leticia Maragno, Olivier Geneste, Delphine Merino, James Whittle, François Vaillant, Jane Visvader, Geoffrey Lindeman, Guillaume Lessene, Elisabetta Marangoni
  • Hydroxyester derivatives, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 10711010
    Abstract: Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R13, Ra, Rb, A and n are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.
    Type: Grant
    Filed: January 15, 2019
    Date of Patent: July 14, 2020
    Assignees: LES LABORATORIES SERVIER, VERNALIS (R&d) LTD
    Inventors: Zoltán Szlávik, András Kotschy, Maïa Chanrion, Didier Demarles, Olivier Geneste, James Edward Paul Davidson, James Brooke Murray, Szabolcs Sipos, Attila Paczal, Balázs Bálint
  • (Hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 10654849
    Abstract: Compounds of formula (I): wherein R1, R2, J, K, L, n and W are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring pro-apoptotic and/or anti-proliferative agents.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: May 19, 2020
    Assignees: LES LABORATOIRES SERVIER, VERNALIS (R&D) LTD
    Inventors: András Kotschy, Csaba Wéber, Attila Vasas, Balázs Molnár, árpád Kiss, Alba Macias, James Brooke Murray, Elodie Lewkowicz, Olivier Geneste, Mäia Chanrion, Didier Demarles, Lisa Ivanschitz
  • Bicyclic derivatives, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 10618909
    Abstract: Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R14, W, A and n are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: April 14, 2020
    Assignees: LES LABORATOIRES SERVIER, VERNALIS (R&D) LTD
    Inventors: Balázs Bálint, Márton Csékei, Zoltán Szabó, Zoltán Szlávik, András Kotschy, Maïa Chanrion, Olivier Geneste, I-Jen Chen, James Edward Paul Davidson, James Brooke Murray, Szabolcs Sipos, Levente Ondi, Ágnes Proszenyák
  • COMBINATION OF A MCL-1 INHIBITOR AND A TAXANE COMPOUND, USES AND PHARMACEUTICAL COMPOSITIONS THEREOF
    Publication number: 20190336505
    Abstract: A combination comprising a MCL-1 inhibitor and a taxane compound, and compositions and uses thereof.
    Type: Application
    Filed: January 5, 2018
    Publication date: November 7, 2019
    Inventors: Dale PORTER, Ensar HALILOVIC, Maïa CHANRION, Ana Leticia MARAGNO, Olivier GENESTE, Delphine MERINO, James WHITTLE, François VAILLANT, Jane VISVADER, Geoffrey LINDEMAN, Guillaume LESSENE, Elisabetta MARANGONI
  • Ammonium derivatives, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 10457689
    Abstract: Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6 and Y are as defined in the description. Medicaments.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: October 29, 2019
    Assignees: LES LABORATOIRES SERVIER, VERNALIS (R&D) LTD
    Inventors: Attila Paczal, Zoltán Szlávik, András Kotschy, Maïa Chanrion, Ana Leticia Maragno, Olivier Geneste, Didier Demarles, Balázs Bálint, Szabolcs Sipos
  • BICYCLIC DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20190248805
    Abstract: Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R14, W, A and n are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.
    Type: Application
    Filed: April 25, 2019
    Publication date: August 15, 2019
    Inventors: Balázs Bálint, Márton Csékei, Zoltán Szabó, Zoltán Szlávik, András Kotschy, Maïa Chanrion, Olivier Geneste, I-Jen Chen, James Edward Paul Davidson, James Brooke Murray, Szabolcs Sipos, Levente Ondi, Ágnes Proszenyák
  • Bicyclic derivatives, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 10323041
    Abstract: Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R14, W, A and n are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: June 18, 2019
    Assignees: LES LABORATOIRES SERVIER, VERNALIS (R&D) LTD
    Inventors: Balazs Balint, Márton Csékei, Zoltán Szabó, Zoltan Szlavik, András Kotschy, Maïa Chanrion, Olivier Geneste, I-Jen Chen, James Edward Paul Davidson, James Brooke Murray, Szabolcs Sipos, Levente Ondi, Ágnes Proszenyák
  • Hydroxyacid derivatives, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 10322131
    Abstract: Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R14, A and n are as defined in the description.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: June 18, 2019
    Assignees: LES LABORATOIRES SERVIER, VERNALIS (R&D) LTD
    Inventors: Zoltan Szlavik, Attila Paczal, Balazs Balint, András Kotschy, Maïa Chanrion, Olivier Geneste, James Edward Paul Davidson, James Brooke Murray, Szabolcs Sipos, Ágnes Proszenyák
  • HYDROXYESTER DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20190161496
    Abstract: Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R13, Ra, Rb, A and n are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.
    Type: Application
    Filed: January 15, 2019
    Publication date: May 30, 2019
    Inventors: Zoltán SZLÁVIK, Andràs Kotschy, Maïa Chanrion, Didier Demarles, Olivier Geneste, James Edward Paul Davidson, James Brooke Murray, Szabolcs Sipos, Attila Paczal, Balázs BÁLINT
  • (HETERO)ARYL-SUBSTITUTED-PIPERIDINYL DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20190144449
    Abstract: Compounds of formula (I): wherein R1, R2, J, K, L, n and W are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring pro-apoptotic and/or anti-proliferative agents.
    Type: Application
    Filed: June 9, 2017
    Publication date: May 16, 2019
    Inventors: András KOTSCHY, Csaba WÉBER, Attila VASAS, Balázs MOLNÁR, Árpád KISS, Alba MACIAS, James Brooke MURRAY, Elodie LEWKOWICZ, Olivier GENESTE, Maïa CHANRION, Didier DEMARLES, Lisa IVANSCHITZ
  • PIPERIDINYL DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20190144448
    Abstract: Compounds of formula (I): wherein R1, R2, R3, n and W are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring pro-apoptotic and/or anti-proliferative agents.
    Type: Application
    Filed: June 9, 2017
    Publication date: May 16, 2019
    Inventors: András KOTSCHY, Csaba WÉBER, Attila VASAS, Balázs MOLNÁR, Árpád KISS, Alba MACIAS, James Brooke MURRAY, Elodie LEWKOWICZ, Olivier GENESTE, Maïa CHANRION, Didier DEMARLES