Abstract: The present disclosure is directed to compounds that are inhibitors of HIF-2? having a structure according to Formula I, and compositions containing those compounds. Methods of using the compounds for the treatment of diseases, disorders, or conditions are also described.

Abstract: The present invention relates to cytolytic bi-component protein complexes consisting of a plurality of molecules of a member of the aegerolysin family and a plurality of molecules of a member of the MACPF superfamily, and particularly to their use for controlling a plant pest, such as for controlling Colorado potato beetle (Leptinotarsa decemlineata) or Western corn rootworm (Diabrotica virgifera virgifera). More specifically, the invention relates to cytolytic bi-component protein complexes formed by a plurality of molecules of one of the aegerolysins ostreolysin A6 (OlyA6), pleurotolysin A2 (PlyA2) and erylysin A (EryA) with a plurality of molecules of pleurotolysin B (PlyB) or similar proteins, which have been shown to be toxic for the aforementioned agricultural pest insects.

Abstract: A multi-cloud service system establishes tunnels and network overlays across multiple CSPs while meeting a criterion for a latency threshold. The system conducts a latency benchmarking evaluation across each cloud region for multiple CSPs and based on the latency bench marking evaluation results, the system may identify a group of cloud regions that satisfy a criterion such as predetermined maximum latency threshold or geographical restriction. The system may provision the group of cloud regions by provisioning a tunnel between nodes of the multiple CSPs. The system further establishes an overlay network on top of the tunnel by encapsulating packets using encapsulation end point such as VTEP (VXLAN tunnel end point) over VXLAN (Virtual Extension Local Area Network), which may help to ensure reliable transmission of packets from pod to pod. The system may inject user data into each node to initiate operations across the provisioned nodes using injected user data.

Abstract: A multi-cloud service system establishes tunnels and network overlays across multiple CSPs while meeting a criterion for a latency threshold. The system conducts a latency benchmarking evaluation across each cloud region for multiple CSPs and based on the latency bench marking evaluation results, the system may identify a group of cloud regions that satisfy a criterion such as predetermined maximum latency threshold or geographical restriction. The system may provision the group of cloud regions by provisioning a tunnel between nodes of the multiple CSPs. The system further establishes an overlay network on top of the tunnel by encapsulating packets using encapsulation end point such as VTEP (VXLAN tunnel end point) over VXLAN (Virtual Extension Local Area Network), which may help to ensure reliable transmission of packets from pod to pod. The system may inject user data into each node to initiate operations across the provisioned nodes using injected user data.

Abstract: A multi-cloud service system establishes tunnels and network overlays across multiple CSPs while meeting a criterion for a latency threshold. The system conducts a latency benchmarking evaluation across each cloud region for multiple CSPs and based on the latency bench marking evaluation results, the system may identify a group of cloud regions that satisfy a criterion such as predetermined maximum latency threshold or geographical restriction. The system may provision the group of cloud regions by provisioning a tunnel between nodes of the multiple CSPs. The system further establishes an overlay network on top of the tunnel by encapsulating packets using encapsulation end point such as VTEP (VXLAN tunnel end point) over VXLAN (Virtual Extension Local Area Network), which may help to ensure reliable transmission of packets from pod to pod. The system may inject user data into each node to initiate operations across the provisioned nodes using injected user data.

Abstract: The invention relates to a method of manufacturing steel parts of sheet metal by hot deep drawing characterized by bringing the semi-finished product into austenitic condition by heating, subsequently cooling its locations, which would undergo undesirable deformation, to a temperature below the austenite temperature, and then completing the forming process.

Abstract: A method of hot forming hybrid parts wherein side-by-side with a thin-walled piece of steel stock, which has been heated to austenite temperature, another piece of stock of another formable metal is placed, The processing temperature of this formable metal corresponds to the temperature at which quenching of the steel stock is interrupted within an interval between the Ms and Mf temperatures. The steel stock and formable metal are then formed together, while the temperature decreases to a temperature which is close to the forming tool temperature. Next, the resulting semi-finished product is cooled to the ambient temperature.

Abstract: A method of producing a microstructure of a high-alloy steel includes heating the metal stock to a temperature between 1270° C. and 1280° C., at a rate between 40° C./s and 45° C./s, followed by compression applied to the metal stock in a thixotropic process, after which the stock is cooled to ambient temperature. A microstructure is also shown, which includes undissolved metal carbides in the form of globular particles of austenite microstructure and of martensite microstructure.

Abstract: The pericardial heart valve replacement (1) is constructed from living tissue of autologous pericardium containing living pericardial interstitial cells (PICs) and a living extracellular matrix (ECM) in the following way: in the first step the size and shape of the patient's native pathological heart valve is determined using real-time three-dimensional transesophageal echocardiography (TEE) or computer tomography (CT angiography) or magnetic resonance imaging (MRI); in the next step a stented (2) or a stentless pericardial heart valve replacement (1) is constructed from a single sheet of living autologous pericardium obtained from the patient; the size and shape of the pericardial heart valve replacement (1) corresponds to the size and shape of the patient's native heart valve and aortic or pulmonary root.

Abstract: An example method of saving and restoring a state of one or more registers for a guest includes detecting exit of a virtual machine mode of a guest running on a virtual machine. A set of registers is accessible by the guest and includes a first subset of registers and a second subset of registers. The method also includes identifying the first subset of registers. The first subset of registers includes one or more registers to be overwritten by the guest upon re-entry of the virtual machine mode. The second subset of registers is mutually exclusive from the first subset of registers. The method further includes after detecting exit of the virtual machine mode of the guest, detecting re-entry of the virtual machine mode of the guest. The method also includes restoring a saved state of the second subset of registers for the guest.

Abstract: A method of producing pressed metal sheet parts in an integrated process to prepare blanks of non-uniform thickness includes the steps of heating a steel sheet blank in heating equipment to the austenite region of the steel of the sheet steel blank in question, then forming the blank into a flat semi-finished product of non-uniform thickness in forming equipment, then immediately thereafter, without any further hearting of the semi-finished product, deep drawing the semi-finished product in deep drawing equipment into a final spatially shaped part. The method may further include cooling down the final spatially shaped part either during the drawing step or immediately after the deep drawing step in a manner which causes the final spatially shaped part to develop hardening microstructure, which imparts high strength to the final shaped part with non-uniform wall thickness.

Abstract: In a first step of the method of achieving TRIP microstructure in steels by deformation heat, steel feedstock is heated to a temperature below the temperature at which austenite begins to form in the steel in question, i.e. below AC1. In a next step, the feedstock is formed into a final product, using applied severe plastic deformation whereby deformation energy causes the temperature of the material to increase to the final temperature between AC1 and AC3, and whereupon the ferrite-pearlite microstructure transforms into austenite. In a third or last process step, the final product is cooled down from the final temperature to the temperature of the bainite nose of the material (B). The cooling is then interrupted and the material is held at the temperature of the bainite nose (B). Consequently, the TRIP microstructure forms. Finally, the product is cooled down to ambient temperature.

Abstract: A method of production of high-strength hollow bodies from multiphase martensitic steels includes a heating process, a forming process and a cooling process. A heating device heats hollow steel stock to the austenitic temperature of the material from which the stock is made. The stock is then converted by deformation in a forming device into a hollow body having the final shape. A cooling device thereafter cools the hollow body such that the material with the original austenite microstructure refined by deformation during the forming process cools to a temperature at which incomplete transformation of austenite to martensite occurs. The retained austenite stabilization is performed in an annealing device by diffusion-based carbon partitioning within the material from which the hollow body is made. The hollow body is cooled in a cooling device to ambient temperature after stabilization.

Abstract: A system and method of interacting with a multi-agent distributed control system employing a plurality of controllers on which are programmed a plurality of agents in which the controllers are coupled by a network are disclosed. The method includes providing a computer program capable of operating a user interface, where the computer program is in communication with the agents via the network. The method further includes displaying agent-related information on the user interface by way of a plurality of windows, where within a first of the windows is further displayed a workflow among at least some of the agents, and within a second of the windows is further displayed at least one of a plurality of messages communicated among at least some of the agents, a work unit requested by at least one of the agents, and message content associated with at least one of the messages.