Patents by Inventor Maarten Leonardus Van Roosmalen

Maarten Leonardus Van Roosmalen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunogenic compositions in particulate form and methods for producing the same
    Patent number: 9585953
    Abstract: The invention relates to the field of immunology and vaccine development, in particular to the development of vaccines based on native antigen oligomers. Provided is an immunogenic composition in particulate form, comprising oligomers of a surface exposed polypeptide of pathogenic origin or tumor origin, or antigenic part thereof, said oligomers being bound non-covalently to a particulate carrier, and a pharmaceutically acceptable diluent or excipient.
    Type: Grant
    Filed: March 22, 2012
    Date of Patent: March 7, 2017
    Assignee: MUCOSIS B.V.
    Inventors: Cornelis Johannes Leenhouts, Bert Jan Haijema, Maarten Leonardus van Roosmalen, Petrus Josephus Marie Rottier, Cornelis Alexander Maria de Haan, Berend Jan Bosch
  • BIFUNCTIONAL PROTEIN ANCHORS
    Publication number: 20160136294
    Abstract: The disclosure relates to the areas of immunology and vaccine delivery. More specifically, it relates to a bacterial vaccine delivery technology with built-in immunostimulatory properties which allow the immobilization of any antigen of interest, without prior antigen modification. Provided is an antigen-loaded immunogenic carrier complex comprising at least one bifunctional polypeptide attached to an immunogenic carrier, the bifunctional polypeptide comprising a peptidoglycan binding domain (PBD) through which the polypeptide is attached to the carrier, fused to an antigen binding domain (ABD) to which at least one antigen of interest is bound. Also described is a pharmaceutical (e.g., vaccine) composition comprising an antigen-loaded immunogenic carrier complex.
    Type: Application
    Filed: January 19, 2016
    Publication date: May 19, 2016
    Inventors: Cornelis Johannes Leenhouts, Maarten Leonardus Van Roosmalen, Tjibbe Bosma
  • BIFUNCTIONAL PROTEIN ANCHORS
    Publication number: 20150196659
    Abstract: The disclosure relates to the areas of immunology and vaccine delivery. More specifically, it relates to a bacterial vaccine delivery technology with built-in immunostimulatory properties which allow the immobilization of any antigen of interest, without prior antigen modification. Provided is an antigen-loaded immunogenic carrier complex comprising at least one bifunctional polypeptide attached to an immunogenic carrier, the bifunctional polypeptide comprising a peptidoglycan binding domain (PBD) through which the polypeptide is attached to the carrier, fused to an antigen binding domain (ABD) to which at least one antigen of interest is bound. Also described is a pharmaceutical (e.g., vaccine) composition comprising an antigen-loaded immunogenic carrier complex.
    Type: Application
    Filed: March 24, 2015
    Publication date: July 16, 2015
    Inventors: Cornelis Johannes LEENHOUTS, Maarten Leonardus VAN ROOSMALEN, Tjibbe BOSMA
  • Bifunctional protein anchors
    Patent number: 9011870
    Abstract: The invention relates to the areas of immunology and vaccine delivery. More specifically, it relates to a bacterial vaccine delivery technology with built-in immunostimulatory properties which allows the immobilization of any antigen of interest, without prior antigen modification. Provided is an antigen-loaded immunogenic carrier complex comprising at least one bifunctional polypeptide attached to an immunogenic carrier, said bifunctional polypeptide comprising a peptidoglycan binding domain (PBD) through which the polypeptide is attached to said carrier, fused to an antigen binding domain (ABD) to which at least one antigen of interest is bound. Also provided is a pharmaceutical (e.g. vaccine) composition comprising an antigen-loaded immunogenic carrier complex of the invention.
    Type: Grant
    Filed: July 20, 2006
    Date of Patent: April 21, 2015
    Assignee: Applied Nanosystems B.V.
    Inventors: Cornelis Johannes Leenhouts, Maarten Leonardus Van Roosmalen, Tjibbe Bosma
  • Immunogenic Compositions In Particulate Form And Methods For Producing The Same
    Publication number: 20140093532
    Abstract: The invention relates to the field of immunology and vaccine development, in particular to the development of vaccines based on native antigen oligomers. Provided is an immunogenic composition in particulate form, comprising oligomers of a surface exposed polypeptide of pathogenic origin or tumour origin, or antigenic part thereof, said oligomers being bound non-covalently to a particulate carrier, and a pharmaceutically acceptable diluent or excipient.
    Type: Application
    Filed: March 22, 2012
    Publication date: April 3, 2014
    Applicant: MUCOSIS B.V.
    Inventors: Cornelis Johannes Leenhouts, Bert Jan Haijema, Maarten Leonardus Van Roosmalen, Petrus Josephus Marie Rottier, Cornelis Alexander Maria De Haan, Berend Jan Bosch
  • MULTIFUNCTIONAL LINKER PROTEIN CONTAINING AN ANTIBODY AGAINST HEMAGGLUTININ, A CONSERVED INFLUENZA ANTIGEN AND AN IMMUNOSTIMULATING CARRIER BINDING DOMAIN
    Publication number: 20110044982
    Abstract: The invention relates to the field of immunology and vaccines. In particular, it relates to proteinaceous substances and the uses thereof in vaccines against infections caused by respiratory pathogens.
    Type: Application
    Filed: September 22, 2009
    Publication date: February 24, 2011
    Inventors: Cornelis Johannes Leenhouts, Maarten Leonardus van Roosmalen, Govert Johan Schouten
  • Bifunctional Protein Anchors
    Publication number: 20090263414
    Abstract: The invention relates to the areas of immunology and vaccine delivery. More specifically, it relates to a bacterial vaccine delivery technology with built-in immunostimulatory properties which allows the immobilization of any antigen of interest, without prior antigen modification. Provided is an antigen-loaded immunogenic carrier complex comprising at least one bifunctional polypeptide attached to an immunogenic carrier, said bifunctional polypeptide comprising a peptidoglycan binding domain (PBD) through which the polypeptide is attached to said carrier, fused to an antigen binding domain (ABD) to which at least one antigen of interest is bound. Also provided is a pharmaceutical (e.g. vaccine) composition comprising an antigen-loaded immunogenic carrier complex of the invention.
    Type: Application
    Filed: July 20, 2006
    Publication date: October 22, 2009
    Inventors: Cornelis Johannes Leenhouts, Maarten Leonardus Van Roosmalen, Tjibbe Bosma