Patents by Inventor Maarten Nieboer

Maarten Nieboer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • In vivo production of cephalosporins
    Publication number: 20060127972
    Abstract: The invention provides improved in vivo production of acylated cephalosporins with higher yield using expandase which is predominantly localised in the cytosol of the host cell.
    Type: Application
    Filed: February 7, 2006
    Publication date: June 15, 2006
    Inventors: Maarten Nieboer, Roelof Bovenberg
  • Method to localize expandase in the cytosol
    Patent number: 6995003
    Abstract: The invention provides DNA, heterologous host cells capable of transcribing, translating or expressing said DNA and methods employing such host cells and cultures thereof for an improved in vivo production of acylated cephalosporins with higher yield. According to the invention, a host cell is provided comprising an enzyme having expandase activity which is predominantly localized in the cytosol (as opposed to localized mainly in or with the peroxisomes or microbodies) of the host cell.
    Type: Grant
    Filed: May 19, 1999
    Date of Patent: February 7, 2006
    Assignee: DSM IP Assets B.V.
    Inventors: Maarten Nieboer, Roelof Ary Lans Bovenberg
  • Process for the fermentative production of deacylated cephalosporins
    Patent number: 6518039
    Abstract: The present invention discloses a process for the production of N-deacylated cephalosporin compounds via the fermentative production of their 7-acylated counterparts.
    Type: Grant
    Filed: May 17, 1999
    Date of Patent: February 11, 2003
    Assignee: DSM N.V.
    Inventors: Maarten Nieboer, Erik De Vroom, Johannis Lugtenburg, Dirk Schipper, Adrianus Wilhelmus Hermanus Vollebregt, Roelof Ary Lans Bovenberg
  • Process for the fermentative production of deacylated cephalosporins
    Patent number: 6410259
    Abstract: The present invention disclosures a process for the production of N-deacylated cephalosporin compounds via the fermentative production of their 7-acylated counterparts.
    Type: Grant
    Filed: August 26, 1999
    Date of Patent: June 25, 2002
    Assignee: DSM Patents & Trademarks
    Inventors: Maarten Nieboer, Erik De Vroom, Johannis Lugtenburg, Dirk Schipper, Adrianus Wilhelmus Hermanus Vollebregt, Roelof Ary Lans Bovenberg
  • PROCESS FOR THE FERMENTATIVE PRODUCTION OF DEACYLATED CEPHALOSPORINS
    Publication number: 20020037547
    Abstract: The present invention discloses a process for the production of N-deacylated cephalosporin compounds via the fermentative production of their 7-acylated counterparts.
    Type: Application
    Filed: May 17, 1999
    Publication date: March 28, 2002
    Inventors: MAARTEN NIEBOER, ERIK DE VROOM, JOHANNIS LUGTENBURG, DIRK SCHIPPER, ADRIANUS WILHELMUS H VOLLEBREGT, ROELOF ARY LANS BOVENBERG