Patents by Inventor Machiko Nagai

Machiko Nagai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Poststatin and related compounds or salts thereof
    Patent number: 5359138
    Abstract: A novel, biologically active substance, poststatin, has been isolated from a culture medium of microorganism belonging to Streptomyces. The novel substance is a peptide compound having a novel structure, wherein the peptide chains have ketone radicals. Thus substance has a high endopeptidase inhibition activity. It is possible to chemically synthesize poststatin related compound having ketone radicals in the peptide chains. These compounds also have an endopeptidase inhibition activity.
    Type: Grant
    Filed: June 29, 1992
    Date of Patent: October 25, 1994
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaI
    Inventors: Tomio Takeuchi, Takaaki Aoyagi, Masa Hamada, Hiroshi Naganawa, Keiji Ogawa, Machiko Nagai, Yasuhiko Muraoka, Makoto Tsuda
  • Poststatin and related compounds or salts thereof
    Patent number: 5162500
    Abstract: A novel, biologically active substance, poststatin, has been isolated from a culture medium of microorganism belonging to Streptomyces. The novel substance is a peptide compound having a novel structure, wherein the peptide chains have ketone radicals. Thus substance has a high endopeptidase inhibition activity. It is possible to chemically synthesize poststatin related compound having ketone radicals in the peptide chains. These compounds also have an endopeptidase inhibition activity.
    Type: Grant
    Filed: December 7, 1990
    Date of Patent: November 10, 1992
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Tomio Takeuchi, Takaaki Aoyagi, Masa Hamada, Hiroshi Naganawa, Keiji Ogawa, Machiko Nagai, Yasuhiko Muraoka, Makoto Tsuda