Patents by Inventor Maciej Zborowski
Maciej Zborowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220176101Abstract: A system and method for pulsed electromagnetic fields (PEMF) tissue engineering enhances musculoskeletal tissue stimulation. A tissue engineering device may include both low and high pulse frequency signal generation components that may alternatively drive one or more coils to generate PEMFs. These PEMFs may be applied to bone tissue, tendons, ligaments, and/or cartilage. A prescribed treatment regimen using the tissue engineering device may include a first period of time where a first pulse frequency is used in treatment that supports tissue proliferation followed by a second period of time where a second pulse frequency (less than the first pulse frequency) is used in treatment that supports tissue differentiation. A treatment regimen may also include, with the frequency characteristic, applying a slew rate to the pulse characteristics that is on the order of around 30 to 100 Tesla per second to drive tissue differentiation in a targeted manner.Type: ApplicationFiled: January 28, 2022Publication date: June 9, 2022Inventors: James T. Ryaby, Erik Waldorff, Ronald Midura, Maciej Zborowski
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Patent number: 11235144Abstract: A system and method for pulsed electromagnetic fields (PEMF) tissue engineering enhances musculoskeletal tissue stimulation. A tissue engineering device may include both low and high pulse frequency signal generation components that may alternatively drive one or more coils to generate PEMFs. These PEMFs may be applied to bone tissue, tendons, ligaments, and/or cartilage. A prescribed treatment regimen using the tissue engineering device may include a first period of time where a first pulse frequency is used in treatment that supports tissue proliferation followed by a second period of time where a second pulse frequency (less than the first pulse frequency) is used in treatment that supports tissue differentiation. A treatment regimen may also include, with the frequency characteristic, applying a slew rate to the pulse characteristics that is on the order of around 30 to 100 Tesla per second to drive tissue differentiation in a targeted manner.Type: GrantFiled: May 18, 2020Date of Patent: February 1, 2022Assignee: ORTHOFIX US LLCInventors: James T. Ryaby, Erik Waldorff, Ronald Midura, Maciej Zborowski
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Publication number: 20200276435Abstract: A system and method for pulsed electromagnetic fields (PEMF) tissue engineering enhances musculoskeletal tissue stimulation. A tissue engineering device may include both low and high pulse frequency signal generation components that may alternatively drive one or more coils to generate PEMFs. These PEMFs may be applied to bone tissue, tendons, ligaments, and/or cartilage. A prescribed treatment regimen using the tissue engineering device may include a first period of time where a first pulse frequency is used in treatment that supports tissue proliferation followed by a second period of time where a second pulse frequency (less than the first pulse frequency) is used in treatment that supports tissue differentiation. A treatment regimen may also include, with the frequency characteristic, applying a slew rate to the pulse characteristics that is on the order of around 30 to 100 Tesla per second to drive tissue differentiation in a targeted manner.Type: ApplicationFiled: May 18, 2020Publication date: September 3, 2020Inventors: James T. Ryaby, Erik Waldorff, Ronald Midura, Maciej Zborowski
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Patent number: 10653881Abstract: A system and method for pulsed electromagnetic fields (PEMF) tissue engineering enhances musculoskeletal tissue stimulation. A tissue engineering device may include both low and high pulse frequency signal generation components that may alternatively drive one or more coils to generate PEMFs. These PEMFs may be applied to bone tissue, tendons, ligaments, and/or cartilage. A prescribed treatment regimen using the tissue engineering device may include a first period of time where a first pulse frequency is used in treatment that supports tissue proliferation followed by a second period of time where a second pulse frequency (less than the first pulse frequency) is used in treatment that supports tissue differentiation. A treatment regimen may also include, with the frequency characteristic, applying a slew rate to the pulse characteristics that is on the order of around 30 to 100 Tesla per second to drive tissue differentiation in a targeted manner.Type: GrantFiled: January 12, 2018Date of Patent: May 19, 2020Assignee: Orthofix, Inc.Inventors: James T. Ryaby, Erik Waldorff, Ronald Midura, Maciej Zborowski
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Publication number: 20180200503Abstract: A system and method for pulsed electromagnetic fields (PEMF) tissue engineering enhances musculoskeletal tissue stimulation. A tissue engineering device may include both low and high pulse frequency signal generation components that may alternatively drive one or more coils to generate PEMFs. These PEMFs may be applied to bone tissue, tendons, ligaments, and/or cartilage. A prescribed treatment regimen using the tissue engineering device may include a first period of time where a first pulse frequency is used in treatment that supports tissue proliferation followed by a second period of time where a second pulse frequency (less than the first pulse frequency) is used in treatment that supports tissue differentiation. A treatment regimen may also include, with the frequency characteristic, applying a slew rate to the pulse characteristics that is on the order of around 30 to 100 Tesla per second to drive tissue differentiation in a targeted manner.Type: ApplicationFiled: January 12, 2018Publication date: July 19, 2018Inventors: James T. Ryaby, Erik Waldorff, Ronald Midura, Maciej Zborowski
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Patent number: 9176111Abstract: A disposable kit for use in directing fluid through a biological cell separator device (10). The kit generally includes a separator tube (22), a buffer fluid container (34), cell sample container (32), separated cell container (60), and flushing fluid container (62), as well as various conduits (36, 38, 42, 50, 50a, 50b) for connecting the containers (32, 34, 60, 62) and separator tube (22) in fluid communication together. A cell separator system is provided including a separator tube (22), magnet (20), pump (120) and a motorized drive unit (96). The motorized drive unit (96) is operatively connected to the magnet (20) to allow the magnet (20) to be moved a sufficient distance away from the separator tube (22) so as to allow cells adhered to the inside surface thereof to be flushed out of the tube (22).Type: GrantFiled: March 19, 2015Date of Patent: November 3, 2015Assignees: Ohio State Innovation Foundation, The Cleveland Clinic FoundationInventors: Jeffrey J. Chalmers, Maciej Zborowski, Lee Moore
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Publication number: 20150252404Abstract: A disposable kit for use in directing fluid through a biological cell separator device (10). The kit generally includes a separator tube (22), a buffer fluid container (34), cell sample container (32), separated cell container (60), and flushing fluid container (62), as well as various conduits (36, 38, 42, 50, 50a, 50b) for connecting the containers (32, 34, 60, 62) and separator tube (22) in fluid communication together. A cell separator system is provided including a separator tube (22), magnet (20), pump (120) and a motorized drive unit (96). The motorized drive unit (96) is operatively connected to the magnet (20) to allow the magnet (20) to be moved a sufficient distance away from the separator tube (22) so as to allow cells adhered to the inside surface thereof to be flushed out of the tube (22).Type: ApplicationFiled: March 19, 2015Publication date: September 10, 2015Inventors: Jeffrey J. Chalmers, Maciej Zborowski, Thomas J. Ward, George Keller, Adam Landis, Michael Ward, Lee Moore
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Publication number: 20130315796Abstract: A disposable kit for use in directing fluid through a biological cell separator device (10). The kit generally includes a separator tube (22), a buffer fluid container (34), cell sample container (32), separated cell container (60), and flushing fluid container (62), as well as various conduits (36, 38, 42, 50, 50a, 50b) for connecting the containers (32, 34, 60, 62) and separator tube (22) in fluid communication together. A cell separator system is provided including a separator tube (22), magnet (20), pump (120) and a motorized drive unit (96). The motorized drive unit (96) is operatively connected to the magnet (20) to allow the magnet (20) to be moved a sufficient distance away from the separator tube (22) so as to allow cells adhered to the inside surface thereof to be flushed out of the tube (22).Type: ApplicationFiled: February 17, 2011Publication date: November 28, 2013Applicant: THE OHIO STATE UNIVERSITYInventors: Jeffrey J. Chalmers, Maciej Zborowski, Thomas J. Ward, George Keller, Adam Landis, Michael Ward, Lee Robert Moore
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Publication number: 20100093052Abstract: Systems and methods are provided separating a first group of cells from a mixture of at least first and second groups of cells in a suspending fluid. The system includes an annular flow channel and at least one magnetic element positioned around the exterior of the annular flow channel as to provide a radially symmetric magnetic field around at least a portion of the annular flow channel. The at least one magnetic element is configured to provide a gradually increasing magnetic field along the axis of flow as to limit the maximum magnetic gradient within the annular flow channel. A pump is operatively connected to a terminal end of the annular flow channel to force the suspending fluid through the annular channel.Type: ApplicationFiled: November 14, 2007Publication date: April 15, 2010Inventors: Jeffrey J. Chalmers, Oscar R. Lara-Velasco, Xiaodong Tong, Maciej Zborowski, Lee R. Moore, Sherif S. Farag
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Publication number: 20070020770Abstract: The present invention provides a MEMS-based integrated particle identification system having a substrate, a magnetic structure, and a bioferrograph. The substrate includes a topside portion, backside portion and a flow system. The flow system includes a flow channel for accepting the flow of a stream of particles to identified. The magnetic structure is in physical communication with the topside and backside portions of the substrate and has at least two pole pieces. A plurality of pole piece embodiments are provided for generating a magnetic field that acts on magnetically susceptible particles in the flow stream. The bioferrograph has at least one sensor for identifying the presence and quantity of magnetically susceptible particles. A plurality of sensor embodiments are also provided.Type: ApplicationFiled: September 27, 2006Publication date: January 25, 2007Inventors: Aaron Fleischman, Shuvo Roy, Jeff Chalmers, Maciej Zborowski
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Publication number: 20050079600Abstract: The present invention provides a MEMS-based integrated particle identification system having a substrate, a magnetic structure, and a bioferrograph. The substrate includes a topside portion, backside portion and a flow system. The flow system includes a flow channel for accepting the flow of a stream of particles to identified. The magnetic structure is in physical communication with the topside and backside portions of the substrate and has at least two pole pieces. A plurality of pole piece embodiments are provided for generating a magnetic field that acts on magnetically susceptible particles in the flow stream. The bioferrograph has at least one sensor for identifying the presence and quantity of magnetically susceptible particles. A plurality of sensor embodiments are also provided.Type: ApplicationFiled: July 24, 2003Publication date: April 14, 2005Inventors: Aaron Fleischman, Shuvo Roy, Jeff Chalmers, Maciej Zborowski
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Patent number: 6623984Abstract: The present invention provides a MEMS-based integrated particle identification system having a substrate, a magnetic structure, and a bioferrograph. The substrate includes a topside portion, backside portion and a flow system. The flow system includes a flow channel for accepting the flow of a stream of particles to identified. The magnetic structure is in physical communication with the topside and backside portions of the substrate and has at least two pole pieces. A plurality of pole piece embodiments are provided for generating a magnetic field that acts on magnetically susceptible particles in the flow stream. The bioferrograph has at least one sensor for identifying the presence and quantity of magnetically susceptible particles. A plurality of sensor embodiments are also provided.Type: GrantFiled: November 1, 2000Date of Patent: September 23, 2003Assignee: The Cleveland Clinic FoundationInventors: Aaron J. Fleischman, Shuvo Roy, Jeff Chalmers, Maciej Zborowski
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Patent number: 6557430Abstract: The present invention provides methods and apparatuses for determining at least one of a plurality of particle physical characteristics. The particle physical characteristics include particle size, shape, magnetic susceptibility, magnetic label density, charge separation, dielectric constant, and derivatives thereof. The method includes generating a region of space having a substantially constant force field, determining the velocity of at least one particle within the region by identifying and locating the particle and its coordinates in at least two temporally defined digital images, and determining the particle physical characteristics from the determined velocity and a predetermined force field magnitude and direction.Type: GrantFiled: July 1, 2002Date of Patent: May 6, 2003Assignees: The Cleveland Clinic Foundation, The Ohio State UniversityInventors: Maciej Zborowski, Jeff Chalmers, Lee Robert Moore
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Publication number: 20030033894Abstract: The present invention provides methods and apparatuses for determining at least one of a plurality of particle physical characteristics. The particle physical characteristics include particle size, shape, magnetic susceptibility, magnetic label density, charge separation, dielectric constant, and derivatives thereof. The method includes generating a region of space having a substantially constant force field, determining the velocity of at least one particle within the region by identifying and locating the particle and its coordinates in at least two temporally defined digital images, and determining the particle physical characteristics from the determined velocity and a predetermined force field magnitude and direction.Type: ApplicationFiled: July 1, 2002Publication date: February 20, 2003Inventors: Maciej Zborowski, Jeff Chalmers, Lee Robert Moore
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Patent number: 6467630Abstract: The present invention provides apparatuses and methods for continuously separating particles of interest from a heterogeneous particle population. The heterogeneity can be based on, for example, magnetic susceptibility, particle size, thermal diffusion, phase solubility, and combinations of the preceding. Based on the heterogeneity, a separation force capable of exploiting the separand (i.e., particles subject to the separation process) is provided. The various embodiments of the present invention preferably employ an annular separation channel, appropriate separation force and flow compartments. In a first embodiment, an annular separation channel having semi-permeable inner and outer cylindrical walls is used to generate lateral convection forces. In a second embodiment of the present invention, an annular separation channel having heat conductive inner and outer cylindrical walls is used to generate thermal diffusion forces.Type: GrantFiled: September 1, 2000Date of Patent: October 22, 2002Assignees: The Cleveland Clinic Foundation, The Ohio State UniversityInventors: Maciej Zborowski, Jeff Chalmers, Lee R. Moore
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Patent number: 6412359Abstract: The present invention provides methods and apparatuses for determining at least one of a plurality of particle physical characteristics. The particle physical characteristics include particle size, shape, magnetic susceptibility, magnetic label density, charge separation, dielectric constant, and derivatives thereof. The method includes generating a region of space having a substantially constant force field, determining the velocity of at least one particle within the region by identifying and locating the particle and its coordinates in at least two temporally defined digital images, and determining the particle physical characteristics from the determined velocity and a predetermined force field magnitude and direction.Type: GrantFiled: June 30, 2000Date of Patent: July 2, 2002Assignees: The Cleveland Clinc Foundation, The Ohio State UniversityInventors: Maciej Zborowski, Jeff Chalmers, Lee Robert Moore
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Patent number: 6142025Abstract: The present invention provides methods and apparatuses for determining at least one of a plurality of particle physical characteristics. The particle physical characteristics include particle size, shape, magnetic susceptibility, magnetic label density, charge separation, dielectric constant, and derivatives thereof. The method includes generating a region of space having a substantially constant force field, determining the velocity of at least one particle within the region by identifying and locating the particle and its coordinates in at least two temporally defined digital images, and determining the particle physical characteristics from the determined velocity and a predetermined force field magnitude and direction.Type: GrantFiled: January 19, 1999Date of Patent: November 7, 2000Assignee: The Cleveland Clinic FoundationInventors: Maciej Zborowski, Jeff Chalmers, Lee Robert Moore
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Patent number: 6120735Abstract: A method and apparatus for the fraction sorting of cells is provided. The invention include a dispensing device, aspirating device, flow channel and a magnetic assembly. A first fractional sorting device includes a dipole fractional cell sorter. The dipole fractional cell sorter includes large aspect ratio flow channel and a dipole magnetic assembly. A second fractional sorting device includes a quadrupole fractional cell sorter. The quadrupole fractional cell sorter includes an annular flow channel having inlet and outlet splitters, and a quadrupole magnetic assembly. The quadrupole magnetic assembly includes pole pieces having projecting members with convex surfaces and in is in physical communication with the annular flow chamber. The method of the present invention provides a flow through fractional cell sorting process which is based on the application of a magnetic force to cells having a range of magnetic labeling densities.Type: GrantFiled: July 13, 1999Date of Patent: September 19, 2000Assignees: The Ohio States University, The Cleveland Clinic FoundationInventors: Maciej Zborowski, Jeff Chalmers, Lee R. Moore
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Patent number: 6082205Abstract: The present invention provides methods and apparatuses for determining at least one of a plurality of particle physical characteristics. The particle physical characteristics include particle size, shape, magnetic susceptibility, magnetic label density, charge separation, dielectric constant, and derivatives thereof. The method includes generating a region of space having a substantially constant force field, determining the velocity of at least one particle within the region by identifying and locating the particle and its coordinates in at least two temporally defined digital images, and determining the particle physical characteristics from the determined velocity and a predetermined force field magnitude and direction.Type: GrantFiled: February 6, 1998Date of Patent: July 4, 2000Assignees: Ohio State University, The Cleveland Clinic FoundationInventors: Maciej Zborowski, Jeff Chalmers, Lee Robert Moore
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Patent number: 5974901Abstract: The present invention provides methods and apparatuses for determining at least one of a plurality of particle physical characteristics. The particle physical characteristics include particle size, shape, magnetic susceptibility, magnetic label density, charge separation, dielectric constant, and derivatives thereof. The method includes generating a region of space having a substantially constant force field, determining the velocity of at least one particle within the region by identifying and locating the particle and its coordinates in at least two temporally defined digital images, and determining the particle physical characteristics from the determined velocity and a predetermined force field magnitude and direction.Type: GrantFiled: February 6, 1998Date of Patent: November 2, 1999Assignees: The Cleveland Clinic Foundation, The Ohio State UniversityInventors: Maciej Zborowski, Jeff Chalmers, Lee Robert Moore