Patents by Inventor Mack J. Schermer
Mack J. Schermer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230313297Abstract: Compositions, kits and methods for detecting a plurality of targets are provided herein. A probe-set composition is provided, including one or more first probes and one or more second probes. Each of the first probe includes a nucleic acid sequence complementary to a nucleic acid barcode of a corresponding target-specific binding partner, a first label, and a cleavage site for a first cleavage agent, wherein the first cleavage agent is capable of releasing the first label. Each of the second probes includes a nucleic acid sequence complementary to a nucleic acid barcode of a corresponding target-specific binding partner, a second label, a quench moiety that renders the second label undetectable, and a cleavage site for the first cleavage agent. The first cleavage agent is capable of releasing the quench moiety, whereby the second label is rendered detectable.Type: ApplicationFiled: April 28, 2023Publication date: October 5, 2023Applicant: Ultivue, Inc.Inventors: Abdul Majeed Mohammed, Mael Manesse, Mack J. Schermer, Mark N. Bobrow, Michael Jules Natan
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Patent number: 11674178Abstract: Compositions, kits and methods for detecting a plurality of targets are provided herein. A probe-set composition is provided, including one or more first probes and one or more second probes. Each of the first probe includes a nucleic acid sequence complementary to a nucleic acid barcode of a corresponding target-specific binding partner, a first label, and a cleavage site for a first cleavage agent, wherein the first cleavage agent is capable of releasing the first label. Each of the second probes includes a nucleic acid sequence complementary to a nucleic acid barcode of a corresponding target-specific binding partner, a second label, a quench moiety that renders the second label undetectable, and a cleavage site for the first cleavage agent. The first cleavage agent is capable of releasing the quench moiety, whereby the second label is rendered detectable.Type: GrantFiled: December 13, 2019Date of Patent: June 13, 2023Assignee: Ultivue, Inc.Inventors: Abdul Majeed Mohammed, Mael Manesse, Mack J. Schermer, Mark N. Bobrow, Michael Jules Natan
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Publication number: 20200190583Abstract: Compositions, kits and methods for detecting a plurality of targets are provided herein. A probe-set composition is provided, including one or more first probes and one or more second probes. Each of the first probe includes a nucleic acid sequence complementary to a nucleic acid barcode of a corresponding target-specific binding partner, a first label, and a cleavage site for a first cleavage agent, wherein the first cleavage agent is capable of releasing the first label. Each of the second probes includes a nucleic acid sequence complementary to a nucleic acid barcode of a corresponding target-specific binding partner, a second label, a quench moiety that renders the second label undetectable, and a cleavage site for the first cleavage agent. The first cleavage agent is capable of releasing the quench moiety, whereby the second label is rendered detectable.Type: ApplicationFiled: December 13, 2019Publication date: June 18, 2020Inventors: Abdul Majeed Mohammed, Mael Manesse, Mack J. Schermer, Mark N. Bobrow, Michael Jules Natan
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Patent number: 9127307Abstract: Encoded bead multiplex assays for chromosomal gains and losses are provided that provide the benefits of complex, large template DNA sources, such as BAC DNA, as the probe material without bead networking or other assay performance problems. Reagents for assaying DNA are described herein which include a plurality of encoded particles having attached amplicons amplified from a template DNA sequence. Each individual attached amplicon includes a nucleic acid sequence identical to a random portion of the template DNA sequence, wherein the amplicons together represent substantially the entire template DNA and wherein the nucleic acid sequence identical to a random portion of the template DNA sequence of each individual amplicon is shorter than the entire template DNA.Type: GrantFiled: February 21, 2013Date of Patent: September 8, 2015Assignee: PerkinElmer Health Sciences, Inc.Inventors: Karl Edwin Adler, Jr., Mack J. Schermer
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Patent number: 8404463Abstract: Encoded bead multiplex assays for chromosomal gains and losses are provided that provide the benefits of complex, large template DNA sources, such as BAC DNA, as the probe material without bead networking or other assay performance problems. Reagents for assaying DNA are described herein which include a plurality of encoded particles having attached amplicons amplified from a template DNA sequence. Each individual attached amplicon includes a nucleic acid sequence identical to a random portion of the template DNA sequence, wherein the amplicons together represent substantially the entire template DNA and wherein the nucleic acid sequence identical to a random portion of the template DNA sequence of each individual amplicon is shorter than the entire template DNA.Type: GrantFiled: March 21, 2011Date of Patent: March 26, 2013Assignee: PerkinElmer Health Sciences, Inc.Inventors: Karl Edwin Adler, Jr., Mack J. Schermer
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Publication number: 20110172117Abstract: Encoded bead multiplex assays for chromosomal gains and losses are provided that provide the benefits of complex, large template DNA sources, such as BAC DNA, as the probe material without bead networking or other assay performance problems. Reagents for assaying DNA are described herein which include a plurality of encoded particles having attached amplicons amplified from a template DNA sequence. Each individual attached amplicon includes a nucleic acid sequence identical to a random portion of the template DNA sequence, wherein the amplicons together represent substantially the entire template DNA and wherein the nucleic acid sequence identical to a random portion of the template DNA sequence of each individual amplicon is shorter than the entire template DNA.Type: ApplicationFiled: March 21, 2011Publication date: July 14, 2011Applicant: PerkinElmer Health Sciences, Inc.Inventors: Karl E. Adler, Mack J. Schermer
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Patent number: 7932037Abstract: Encoded bead multiplex assays for chromosomal gains and losses are provided that provide the benefits of complex, large template DNA sources, such as BAC DNA, as the probe material without bead networking or other assay performance problems. Reagents for assaying DNA are described herein which include a plurality of encoded particles having attached amplicons amplified from a template DNA sequence. Each individual attached amplicon includes a nucleic acid sequence identical to a random portion of the template DNA sequence, wherein the amplicons together represent substantially the entire template DNA and wherein the nucleic acid sequence identical to a random portion of the template DNA sequence of each individual amplicon is shorter than the entire template DNA.Type: GrantFiled: March 26, 2008Date of Patent: April 26, 2011Assignee: PerkinElmer Health Sciences, Inc.Inventors: Karl Edwin Adler, Mack J. Schermer
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Publication number: 20090148841Abstract: Encoded bead multiplex assays for chromosomal gains and losses are provided that provide the benefits of complex, large template DNA sources, such as BAC DNA, as the probe material without bead networking or other assay performance problems. Reagents for assaying DNA are described herein which include a plurality of encoded particles having attached amplicons amplified from a template DNA sequence. Each individual attached amplicon includes a nucleic acid sequence identical to a random portion of the template DNA sequence, wherein the amplicons together represent substantially the entire template DNA and wherein the nucleic acid sequence identical to a random portion of the template DNA sequence of each individual amplicon is shorter than the entire template DNA.Type: ApplicationFiled: March 26, 2008Publication date: June 11, 2009Applicant: PerkinElmer LAS, Inc.Inventors: Karl E. Adler, Mack J. Schermer
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Patent number: 7521245Abstract: A method and apparatus are provided for washing and drying pins in a microarray spotting instrument. The apparatus includes an array of chambers, each for receiving one of the pins of the spotting instrument. To wash the pins, streams of wash fluid are directed at the pins. To dry the pins, a gas such as air is flowed over pin surfaces.Type: GrantFiled: June 5, 2000Date of Patent: April 21, 2009Assignee: PerkinElmer LAS, Inc.Inventors: Avery Osgood, Mack J. Schermer, Marc Silvagni
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Patent number: 7413893Abstract: The invention provides an apparatus for interrogating an optical biosensor. The apparatus includes (a) locating means for positioning one or more optical biosensors; (b) calibration means for generating a reference measurement; (c) one or more biosensors for generating one or more sample measurements, the biosensors being substantially planar and removable from the apparatus; (d) a reading means for interrogating biosensor and calibration means, and (e) a transport means for moving one or more of a biosensor, the calibration means and the reading means, whereby the reading means is positioned to interrogate the biosensor and the calibration means.Type: GrantFiled: June 9, 2004Date of Patent: August 19, 2008Assignee: PerkinElmer LAS, Inc.Inventors: Mack J. Schermer, Mark Norman Bobrow, Philip R. Buzby, Thomas R. Mullinax
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Patent number: 7335338Abstract: A method and apparatus are provided for automatically sensing the presence (or absence) of spot dispensers such as pins in various possible mounting locations in the printhead of a microarray spotting instrument. Pin-location data obtained by the method and apparatus is provided to the computer controller of the instrument, which uses the data to control the motion of the printhead during operation of the instrument. A pin detection apparatus includes one or more sensor elements that automatically sense possible pin locations in the printhead for the presence of pins. The sensor elements are preferably arranged in an array corresponding to the array of pin locations in the printhead so that pin detection at each pin location can be performed simultaneously. Various types of sensor elements can be used to locate pins in a printhead. For example, sensors can be used that are remote from or attached to a printhead.Type: GrantFiled: April 11, 2005Date of Patent: February 26, 2008Assignee: PerkinElmer LAS, Inc.Inventors: Mack J. Schermer, C. Brian Candiloro
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Patent number: 7233391Abstract: Methods and systems are disclosed that include an optical device for providing information about one or more samples. The system includes well(s) for holding the sample(s), and in one embodiment, the optical device(s) have non-parallel sidewalls optically contacting the well(s) for providing the information about the sample(s) in the well(s). In some embodiments the optical devices may be truncated prism(s). In some embodiments the optical devices are part of a unibody structure with the well(s).Type: GrantFiled: November 12, 2004Date of Patent: June 19, 2007Assignee: PerkinElmer LAS, Inc.Inventors: Mack J. Schermer, Carl Brian Candiloro
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Patent number: 7209836Abstract: A method and system are disclosed for automatically creating crosstalk-corrected data of a microarray utilizing calibration dye spots each of which comprises a single pure dye. A microarray scanner, such as a confocal laser microarray scanner, generates dye images, each of which contains at least one of the calibration dye spots for each of the output channels of the scanner. For each of the calibration dye spots, an output of each of the output channels is measured to obtain output measurements. A set of correction factors is computed from the output measurements to correct the data subsequently gathered from the microarray scanner. In other words, the correction factors are applied to quantitation or measurement data obtained from microarray images which contain spots having dyes of known or unknown excitation or emission spectra to obtain crosstalk-corrected data.Type: GrantFiled: July 16, 1999Date of Patent: April 24, 2007Assignee: PerkinElmer LAS, Inc.Inventors: Mack J. Schermer, Roger D. Dowd, Jun Yang
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Patent number: 7031528Abstract: A scanner system analyses data plotted in a scatter plot in accordance with user-specified criteria or statistical measures from the data population, to produce a scatter plot that displays in the plotted data the boundaries for the selection of out-lyer points and/or otherwise visually denotes in the plotted data which points are the out-lyer points. The scanner system analyzes the underlying data based on user-specified differential expression ratios, or based on criteria associated with the statistics of the data population, to produce out-lyer boundaries that are represented by diverging lines. Alternatively, the system may analyze the underlying data based on absolute expression levels, to produce boundaries that are represented in the plot by lines that meet at an identity line of slope 1.Type: GrantFiled: August 6, 2003Date of Patent: April 18, 2006Assignee: PerkinElmer LAS, Inc.Inventors: Mack J. Schermer, Todd J. Stephan
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Patent number: 6878554Abstract: A method and apparatus are provided for automatically sensing the presence (or absence) of spot dispensers such as pins in various possible mounting locations in the printhead of a microarray spotting instrument. Pin-location data obtained by the method and apparatus is provided to the computer controller of the instrument, which uses the data to control the motion of the printhead during operation of the instrument. A pin detection apparatus includes one or more sensor elements that automatically sense possible pin locations in the printhead for the presence of pins. The sensor elements are preferably arranged in an array corresponding to the array of pin locations in the printhead so that pin detection at each pin location can be performed simultaneously. Various types of sensor elements can be used to locate pins in a printhead. For example, sensors can be used that are remote from or attached to a printhead.Type: GrantFiled: March 20, 2000Date of Patent: April 12, 2005Assignee: PerkinElmer LAS, Inc.Inventors: Mack J. Schermer, C. Brian Candiloro
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Patent number: 6756232Abstract: The disclosed pin-lifter can selectively lift pins partially out of a printhead of a spotting instrument and thereby prevent the lifted pins from contacting the substrate during any printing. Methods of using pin-lifters to increase the rate of production of compact microarrays are disclosed.Type: GrantFiled: March 20, 2000Date of Patent: June 29, 2004Assignee: PerkinElmer LAS, Inc.Inventors: Mack J. Schermer, C. Brian Candiloro, Paul E. Glynn
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Publication number: 20040096367Abstract: The disclosed pin-lifter can selectively lift pins partially out of a printhead of a spotting instrument and thereby prevent the lifted pins from contacting the substrate during any printing. Methods of using pin-lifters to increase the rate of production of compact microarrays are disclosed.Type: ApplicationFiled: November 18, 2003Publication date: May 20, 2004Applicant: PerkinElmer LAS, Inc.Inventors: Mack J. Schermer, C. Brian Candiloro, Paul E. Glynn
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Publication number: 20040028277Abstract: A scanner system analyses data plotted in a scatter plot in accordance with user-specified criteria or statistical measures from the data population, to produce a scatter plot that displays in the plotted data the boundaries for the selection of out-lyer points and/or otherwise visually denotes in the plotted data which points are the out-lyer points. The scanner system analyzes the underlying data based on user-specified differential expression ratios, or based on criteria associated with the statistics of the data population, to produce out-lyer boundaries that are represented by diverging lines. Alternatively, the system may analyze the underlying data based on absolute expression levels, to produce boundaries that are represented in the plot by lines that meet at an identity line of slope 1.Type: ApplicationFiled: August 6, 2003Publication date: February 12, 2004Inventors: Mack J. Schermer, Todd J. Stephan
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Patent number: 6642054Abstract: The disclosed spotting instrument includes one or more sensors that are mechanically fixed to the instrument's printhead. The sensors enable the instrument to detect whether a substrate is mounted in a particular holder of the instrument's substrate station prior to attempting to print spots onto that substrate. Similarly, the sensors enable the instrument to detect whether a reservoir is mounted in a particular holder of the instrument's well station prior to attempting to collect a sample of target material from that reservoir. The sensors also enable the instrument to read bar code labels affixed to substrates or reservoirs mounted in the instrument.Type: GrantFiled: June 14, 2002Date of Patent: November 4, 2003Assignee: Packard Instrument CompanyInventors: Mack J. Schermer, Mona L. Phaff
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Patent number: 6631211Abstract: A scanner system analyses data plotted in a scatter plot in accordance with user-specified criteria or statistical measures from the data population, to produce a scatter plot that displays in the plotted data the boundaries for the selection of out-lyer points and/or otherwise visually denotes in the plotted data which points are the out-lyer points. The scanner system analyzes the underlying data based on user-specified differential expression ratios, or based on criteria associated with the statistics of the data population, to produce out-lyer boundaries that are represented by diverging lines. Alternatively, the system may analyze the underlying data based on absolute expression levels, to produce boundaries that are represented in the plot by lines that meet at an identity line of slope 1.Type: GrantFiled: July 8, 1999Date of Patent: October 7, 2003Assignee: PerkinElmer LAS, Inc.Inventors: Mack J. Schermer, Todd J. Stephan