Abstract: The present disclosure relates to nitenin analogue compounds (of formulas I, II, III and IV) and their use as pharmaceutical agent in the treatment, prevention or reduction of both acute and chronic pain. The mode of action disclosed herein allows nitenin and nitenin analogue compounds to act as analgesic through reduction of K30 currents rather than their potentiation. Related to their high efficacy in the treatment of pain, these compounds are highly selective for slow voltage-activated potassium (K30 ) currents expressed in the small diameter dorsal root neurons (sDRGns), mainly on those mediated by the voltage-dependent potassium channel (KV), KV1.3. Such findings, together with those showing that nitenin and nitenin analogue compounds act as activity dependent blockers also lead to very reduced side-effects.

Abstract: The present patent application relates to the use of antagonists of delayed rectifier potassium (K+) channels, more specifically Kv1.3 antagonists, as pharmaceutical agents in the treatment, prevention or reduction of both acute and chronic pain. The results and mode of action disclosed herein describe how Kv1.3 antagonists may act as analgesics through reduction of K+ currents rather than their potentiation. With regard to their high efficacy in the treatment of pain, these compounds are highly selective for slow delayed rectifier voltage-activated potassium (K+) currents. Such findings, together with those showing that nitenin, PSORA-4, PAP-1 and AM92016 hydrochloride act as K+ channel blockers and by their effects on K+ current inactivation profiles, also translate into an analgesic effect with reduced side effects. The results disclosed herein show that compounds that inhibit delayed rectifying Kv1.

Abstract: The invention relates to a method for fine machining a cylindrical workpiece surface of a workpiece blank by means of a fine machining tool. Said method comprising the following steps: generating a relative rotational movement between a tool and a workpiece blank about a machining axis which is concentric to a cylindrical workpiece surface of the workpiece blank; generating a relative feed rate between the tool and the workpiece blank along the machining axis; detecting an actual value of a process variable which is a function of a relative force between the tool and the workpiece blank and which can assume a plurality of process variable values; and continuously controlling the process variable by changing the relative feed rate in such a way that the more the relative feed rate changes, the more the actual value of the process variable deviates from a desired value of the process variable.

Abstract: Water-based acrylic adhesive compositions comprising (A) an acrylic emulsion comprising an acrylic copolymer particle dispersed in an aqueous medium, (B) a crosslinking agent comprising a hydrophilic aliphatic isocyanate, and (C) a silane compound incorporated into the crosslinking agent (B) are disclosed. In some embodiments, the silane compound (C) incorporated into the crosslinking agent (B) is selected from the group consisting of (3-Glycidyloxypropyl)trimethoxysilane, 3-(Triethoxysilyl)propyl isocyanate, and combinations thereof. Methods for preparing water-based acrylic adhesive compositions also disclosed. Methods for preparing a laminate structure suitable for use in a flexible food packaging article are still further disclosed. Flexible food packaging articles including the disclosed water-based acrylic adhesive compositions are also disclosed.

Abstract: New aminoalkoxyimino derivatives at position 3 of substituted B-homoandrostanes and B-heteroandrostanes, processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, such as heart failure and hypertension. In particular compounds having the general formula (I) are described, where the radicals have the meanings described in detail in the application.

Abstract: A phase locked loop (PLL) includes a frequency detector and a type 1 PLL including a phase detector. The phase detector produces a phase error signal indicative of a difference in phase between a reference signal and a feedback signal, while the frequency detector produces a frequency error signal indicative of a difference in frequency between the reference signal and the feedback signal. Logic switches between the phase detector and the frequency detector based on the frequency error signal.

Abstract: A phase locked loop (PLL) includes a frequency detector and a type 1 PLL including a phase detector. The phase detector produces a phase error signal indicative of a difference in phase between a reference signal and a feedback signal, while the frequency detector produces a frequency error signal indicative of a difference in frequency between the reference signal and the feedback signal. Logic switches between the phase detector and the frequency detector based on the frequency error signal.

Abstract: New aminoalkoxyimino derivatives at position 3 of substituted B-homoandrostanes and B-heteroandrostanes, processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, such as heart failure and hypertension. In particular compounds having the general formula (I) are described, where the radicals have the meanings described in detail in the application.

Abstract: A phase locked loop (PLL) with small size and improved performance is achieved using a type 1 PLL, a frequency detector and logic for switching between the type 1 PLL and frequency detector. The logic disables the type 1 PLL and enables the frequency detector to bring the frequency of a PLL output signal to within a frequency locking range of the type 1 PLL, and then disables the frequency detector and enables the type 1 PLL to lock the phase of the PLL output signal.

Abstract: A tuneable laser assembly includes a substrate having formed thereon a plurality of tuneable lasers including distributed Bragg reflector (DBR) tuning sections. The lasers have respective emission wavelengths and tuning ranges such that the laser assembly can be tuned over a quasi-continuous predetermined wavelength range. The assembly also includes a plurality of waveguides coupled to the lasers to receive therefrom the respective emission wavelengths as well as an optical coupler coupled to the waveguides to receive thereby the emissions wavelengths from the lasers. An optical amplifier is coupled to the optical coupler to amplify the emission wavelengths of the lasers coupled via the optical coupler. The tuning sections of the DBR lasers have a length in the range of about 150-200 um and are of the same optical waveguide of the waveguides routing the emission wavelengths to said optical coupler.