Abstract: A method and composition that allows for the penetration of lipid insoluble medicaments through cell membranes using small S-Allyl-containing molecules with phospholipid permeable molecules as carrier molecules. S-Allyl-containing compounds can include alliin, allicin, Allium sativum extract and DMSO. Lipid insoluble medicaments can include 1% xylocaine, curcumin, acyclovir, valacyclovir, famciclovir, terbenafin, griseofulvin, clotrimazole, ketoconazole, clindamycin, neomycin, polysporin, bactricin, among others. The lipid insoluble medicaments are mixed with the phospholipid permeable molecules and painted on the skin using a swab or other suitable tool, thereby allowing for penetration of the medicament and providing relief from pain potentially caused by a subsequent injection. The composition can also be administered through an inhaler or directly into mucous membranes.

Abstract: Symmetrical curcuminoids molecular compounds that have been found to have anti-injury activity. It has been shown to benefit burns, injured and inflamed skin and mucous membrane and photodamaged skin. The improvement is mediated via inhibition of phosphorylase kinase activity. Phosphorylase kinase is released within 5 minutes following injury. Blocking the elevated phosphorylase kinase activity released after injury by phosphorylase kinase inhibitors, such as symmetrical curcuminoids, results in rapid reversal of burns, skin and mucous membrane injury and inflammation, repair of photodamaged skin, and prevention of scar tissue formation after injury.