Patents by Inventor Madeleine Broll

Madeleine Broll has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4283420
    Abstract: The chemical compounds of the invention are useful as the active compound in drugs because of their anticonvulsant and/or antianoxic activity. They have the general formula ##STR1## wherein Z is a hydroxyl group; a group--OM wherein M is an alkali metal atom or an equivalent atom fraction of an alkaline-earth metal or an amino group such as --NH.sub.2, and R is a linear or branched alkyl group containing from 1 to 9 carbon atoms, and optionally substituted by one or more halogen atoms; a linear or branched alkenyl or alkynyl, alkoxyalkyl, or acylalkyl group containing from 2 to 9 carbon atoms and optionally substituted by one or more halogen atoms; an aryl or arylalkyl or aryloxyalkyl group comprising at least one aromatic radical and an alkyl chain having from 1 to 4 carbon atoms.
    Type: Grant
    Filed: April 18, 1979
    Date of Patent: August 11, 1981
    Assignee: Labaz
    Inventors: Charles Pigerol, Jean-Claude Vernieres, Pierre Eymard, Jacques Simiand, Madeleine Broll, Jean-Yves Lacolle
  • Patent number: 4139634
    Abstract: Indole derivatives of the formula: ##STR1## wherein R.sub.1 represents a hydrogen atom or a methyl radical, R.sub.2 and R.sub.3, which are the same or different, each represent a hydrogen atom, a methyl or ethyl radical, a benzyl radical or represent together a pentamethylene, hexamethylene, oxydiethylene or N-methylaminodiethylene chain, forming thus a cycle with the nitrogen atom, R.sub.4 represents a phenyl, 2', 4'-dimethyl-phenyl, isopropyl, cyclopropyl, 1-methyl-cyclopropyl, cyclopentyl or cyclohexyl radical, R.sub.5 represents a hydrogen atom, a branched- or straight-chain alkyl radical containing from 1 to 3 carbon atoms, a methylthio or ethylthio radical or a straight-chain acyl radical containing from 2 to 6 carbon atoms, R.sub.6 represents a hydrogen atom or a halogen atom, a methyl, methoxy, hydroxy, carboxy, nitro, amino, methylamino or dimethylamino radical, R.sub.7 represents a hydrogen atom or a halogen atom and n is 1 or 2, with the proviso that two at least of the groups R.sub.5, R.sub.
    Type: Grant
    Filed: May 20, 1977
    Date of Patent: February 13, 1979
    Assignee: Labaz
    Inventors: Charles Pigerol, Paul DE Cointet de Fillain, Pierre Eymard, Jean-Pierre Werbenec, Madeleine Broll
  • Patent number: 4057644
    Abstract: Methylamine derivatives of the formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, wherein R.sub.1 and R.sub.3 each represent a hydrogen atom or a straight- or branched-chain alkyl, alkenyl or alkynyl radical containing from 1 to 6 carbon atoms, R.sub.2 represents a straight- or branched-chain alkyl, alkenyl or alkynyl radical containing from 2 to 7 carbon atoms with the proviso that when R.sub.2 represents an alkenyl radical of the formula CH.dbd.CH--R.sub.6 or an alkynyl radical of the formula C.tbd.C--R.sub.6, in which R.sub.6 represents a hydrogen atom or a straight- or branched-chain alkyl radical of 1 to 5 carbon atoms, R.sub.1 and R.sub.3 each represent an atom of hydrogen or an alkyl radical, R.sub.4 and R.sub.5, which are the same or different, each represent a hydrogen atom, a straight- or branched-chain alkyl, alkenyl or alkynyl radical containing from 1 to 5 carbon atoms or an .omega.-hydroxyalkyl radical containing from 2 to 5 carbon atoms or R.sub.4 and R.sub.
    Type: Grant
    Filed: July 22, 1976
    Date of Patent: November 8, 1977
    Assignee: Labaz
    Inventors: Charles Pigerol, Pierre Eymard, Jean-Claude Vernieres, Jean-Pierre Werbenec, Madeleine Broll
  • Patent number: 4032660
    Abstract: Acetoxime derivatives of formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3, which may be the same or different, each represent a branched- or straight-chain alkyl radical having from 1 to 4 carbon atoms or R.sub.1 and R.sub.2, when they are taken together, represent with the carbon atom to which they are attached, a cyclohexyl group, are useful for treating disturbances of the mental functions including anxiety and as anticonvulsants.
    Type: Grant
    Filed: June 5, 1975
    Date of Patent: June 28, 1977
    Assignee: Labaz
    Inventors: Georges Marcel Taillandier, Jean-Louis Alain Benoit-Guyod, Andre Louis Boucherle, Pierre Luc Eymard, Madeleine Broll
  • Patent number: 4025649
    Abstract: Acetic acid derivatives of the formula: ##STR1## and pharmaceutically acceptable alkali metal salts thereof, wherein R represents the radical ##STR2## in which R.sub.1 and R.sub.2, which may be the same or different, each represent an alkyl radical having from 1 to 4 carbon atoms, R.sub.3 represents a hydrogen atom or a methyl radical and n is an integer in the range of from 0 to 3 inclusive.They possess a competitive inhibitory activity with respect to .gamma.-aminobutyric .alpha.-ketoglutaric transaminase as well as antianoxic and anticonvulsant properties and they are useful for treating central neurological disorders whether resulting or not from cerebral ischemia.
    Type: Grant
    Filed: June 18, 1975
    Date of Patent: May 24, 1977
    Assignee: Labaz
    Inventors: Georges Marcel Taillandier, Jean-Louis Alain Benoit-Guyod, Andre Louis Boucherle, Pierre Luc Eymard, Madeleine Broll, Bernard Ferrandes