Patents by Inventor Madeleine Henley

Madeleine Henley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Small molecule binders of the oncogenic fusion transcription factor PAX3-FOXO1
    Patent number: 11964022
    Abstract: The present disclosure provides compounds having the general formula P-L-U, or pharmaceutically acceptable salts thereof, wherein P is a FOXO1 fusion protein binding moiety, L is a bivalent linker, and U is an ubiquitin ligase binding moiety. Also provided are pharmaceutical compositions containing such compounds and methods of using such compounds.
    Type: Grant
    Filed: September 16, 2022
    Date of Patent: April 23, 2024
    Assignees: Massachusetts Institute of Technology, Universität Zürich
    Inventors: Angela Nicole Koehler, Shelby Doyle, Becky Leifer, Madeleine Henley, Beat W. Schaefer, Marco Wachtel