Patents by Inventor Madeleine Joullie

Madeleine Joullie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tamandarin analogs and fragments thereof and methods of making and using
    Publication number: 20070149446
    Abstract: The present invention is directed to a compound of Formula I wherein R1, R2, R3, R4, R5, R6, W, X, Y, and Z are defined herein. The compounds of the present invention are useful as anticancer agents. Specifically, the compounds are useful for treating or preventing cancer and tumor growth. The present invention is also directed to compositions comprising a compound according to the above formula. The present invention is also directed to methods of using a compound according to the above formula.
    Type: Application
    Filed: March 19, 2004
    Publication date: June 28, 2007
    Applicant: The Trustees of the University of Pennsylvania Center for Technology Transfer
    Inventor: Madeleine Joullie
  • Deoxo-proline-containing tamandarin and didemnin analogs, dehydro-proline-containing tamandarin and didemnin analogs, and methods of making and using them
    Publication number: 20070129289
    Abstract: The present invention relates to tamandarin and didemnin analogs which have a deoxo-proline residue or a dehydro-proline residue in their structure. These analogs are useful as anti-cancer agents and for other purposes. Methods of making these analogs and methods of using them as inhibitors of protein synthesis, cell growth, and tumorigenesis and as enhancers of apoptosis are also provided.
    Type: Application
    Filed: June 20, 2006
    Publication date: June 7, 2007
    Applicant: The Trusees of the University of Pennsylvania
    Inventors: Madeleine Joullie, Bo Liang, Xiaobin Ding
  • Didemnin analogs and fragments and methods of making and using them
    Publication number: 20070111928
    Abstract: The present invention relates to macrocyclic depsipeptides, including didemnin analogs and fragments thereof, which are useful as anti-cancer agents and for other purposes. The invention includes numerous didemnin analogs and fragments and methods of making them. Methods of using these compounds as inhibitors of protein synthesis, cell growth, and tumorigenesis and as enhancers of apoptosis are also provided.
    Type: Application
    Filed: October 13, 2006
    Publication date: May 17, 2007
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Madeleine Joullie, Bo Liang