Abstract: The present invention is directed to a compound of Formula I wherein R1, R2, R3, R4, R5, R6, W, X, Y, and Z are defined herein. The compounds of the present invention are useful as anticancer agents. Specifically, the compounds are useful for treating or preventing cancer and tumor growth. The present invention is also directed to compositions comprising a compound according to the above formula. The present invention is also directed to methods of using a compound according to the above formula.

Abstract: The present invention relates to macrocyclic depsipeptides, including didemnin analogs and fragments thereof, which are useful as anti-cancer agents and for other purposes. The invention includes numerous didemnin analogs and fragments and methods of making them. Methods of using these compounds as inhibitors of protein synthesis, cell growth, and tumorigenesis and as enhancers of apoptosis are also provided.

Abstract: The present invention relates to tamandarin and didemnin analogs which have a deoxo-proline residue or a dehydro-proline residue in their structure. These analogs are useful as anti-cancer agents and for other purposes. Methods of making these analogs and methods of using them as inhibitors of protein synthesis, cell growth, and tumorigenesis and as enhancers of apoptosis are also provided.

Abstract: The present invention relates to macrocyclic depsipeptides, including didemnin analogs and fragments thereof, which are useful as anti-cancer agents and for other purposes. The invention includes numerous didemnin analogs and fragments and methods of making them. Methods of using these compounds as inhibitors of protein synthesis, cell growth, and tumorigenesis and as enhancers of apoptosis are also provided.

Abstract: The present invention relates to tamandarin and didemnin analogs which have a deoxo-proline residue or a dehydro-proline residue in their structure. These analogs are useful as anti-cancer agents and for other purposes. Methods of making these analogs and methods of using them as inhibitors of protein synthesis, cell growth, and tumorigenesis and as enhancers of apoptosis are also provided.

Abstract: The present invention is directed to analogs of galanthamine of the structure 1

Abstract: The present invention relates to macrocyclic depsipeptides, including didemnin analogs and fragments thereof, which are useful as anti-cancer agents and for other purposes. The invention includes numerous didemnin analogs and fragments and methods of making them. Methods of using these compounds as inhibitors of protein synthesis, cell growth, and tumorigenesis and as enhancers of apoptosis are also provided.

Abstract: The present invention is directed to analogs of galanthamine of the structure wherein the R terms are herein defined, for use in treating Alzheimer's disease.

Abstract: The present invention relates to macrocyclic depsipeptides, including didemnin analogs and fragments thereof, which are useful as anti-cancer agents and for other purposes. The invention includes numerous didemnin analogs and fragments and methods of making them. Methods of using these compounds as inhibitors of protein synthesis, cell growth, and tumorigenesis and as enhancers of apoptosis are also provided.

Abstract: The present invention relates to tamandarin and didemnin analogs which have a deoxo-proline residue or a dehydro-proline residue in their structure. These analogs are useful as anti-cancer agents and for other purposes. Methods of making these analogs and methods of using them as inhibitors of protein synthesis, cell growth, and tumorigenesis and as enhancers of apoptosis are also provided.

Abstract: Compounds of the formula wherein the broken line represents an optionally present double bond, and R1-R3, R4, R6 and R9 are as defined herein, and compositions containing these compounds can be used to inhibit acetylcholinesterase activity and treat Alzheimer's Disease.

Abstract: Analogs of galanthamine having the formula: wherein R1 and R2 are each independently selected from the group consisting of hydroxyl, alkoxy, aryloxy, alkyl carbonate, phenyl carbonate, benzyl carbonate, aliphatic carbamate, aryl carbamate and alkanoyloxy groups wherein said phenyl, aryl or benzyl groups may optionally be substituted by an R5 group selected from the group consisting of alkyl, alkoxy, fluoro, chloro, bromo and trifluoromethyl groups and R3 is selected from the group consisting of hydrogen and straight or branched chain carbon atoms of from one to six carbon atoms and alkyl phenyl groups are useful in the treatment of Alzheimer's disease and related dementias.

Abstract: A method of treating Alzheimer's disease and related dementias by treatment with analogs of galanthamine, particularly those wherein the methoxy and hydroxy substituents are replaced by, for example carbamate groups, the methoxy is replaced by hydroxy and esters of galanthamine and O-desmethyl galanthamine. Many of the useful compounds are novel.

Abstract: The invention includes compositions comprising and methods of using 1,2-indanedione derivatives for detecting an amine compound such as an amino acid. Methods of detecting and recording the pattern of a fingerprint on a surface are also included, as are a kit for detecting an amine compound such as a constituent of a fingerprint. The invention further includes a device for developing a fingerprint and a method of making 1,2-indanedione derivatives.

Abstract: The present invention provides polyanionic, substituted CDs having cellular growth modulating-activity. The invention further provides CDs having anionic groups on one side of the CD molecule. Therapeutic methods for using, as well as methods of making the CD compounds of the invention, are also disclosed herein.

Abstract: The present invention provides polyanionic, substituted CDs having cellular growth modulating activity. The invention further provides CDs having anionic groups on one side of the CD molecule. Therapeutic methods for using, as well as methods of making the CD compounds of the invention, are also disclosed herein.

Abstract: The invention relates to highly water soluble substituted .alpha.-, .beta.- or .gamma.-cyclodextrin sulfates associated with a physiologically acceptable cation. Pathological or otherwise undesirable cell or tissue growth in mammals, including humans, is inhibited by administering thereto (1) a water-soluble substituted cyclodextrin sulfate salt, together with (2) a growth-inhibiting organic compound. The growth-inhibiting compound (2) may be asteroid having no inhibiting effect in the absence of (1), or an organic compound which may be an active growth inhibitor, the action of which is potentiated by (1). The invention provides a method for inhibiting angiogenesis and controlling the growth of tumors as well as treating other diseases and pathological conditions associated with undesired cell or tissue growth, including angiogenesis.