Patents by Inventor Madeleine Sitton

Madeleine Sitton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TARGETED GENOMIC INTEGRATION TO RESTORE NEUROFIBROMIN CODING SEQUENCE IN NEUROFIBROMATOSIS TYPE 1 (NF1)
    Publication number: 20230201375
    Abstract: Disclosed herein are systems and methods for the treatment of NF1 in a subject. The CRISPR/Cas-based genome editing systems may include a polynucleotide sequence encoding a guide RNA (gRNA) targeting a fragment of a mutant NF1 gene, a polynucleotide sequence encoding a Cas protein or a fusion protein comprising the Cas protein, and a polynucleotide sequence encoding a donor sequence comprising a fragment of a wild-type NF1 gene.
    Type: Application
    Filed: April 27, 2021
    Publication date: June 29, 2023
    Inventors: Charles A. Gersbach, Madeleine Sitton