Patents by Inventor Madeline Butler

Madeline Butler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antisense modulation of CD40 ligand expression
    Publication number: 20060160758
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of CD40 ligand. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding CD40 ligand. Methods of using these compounds for modulation of CD40 ligand expression and for treatment of diseases associated with expression of CD40 ligand are provided.
    Type: Application
    Filed: January 20, 2005
    Publication date: July 20, 2006
    Inventors: C. Bennett, Susan Freier, Brenda Baker, Brett Monia, Nicholas Dean, Hong Zhang, Susan Murray, Lex Cowsert, Madeline Butler, Robert McKay, Donna Ward, William Gaarde, Ian Popoff, Jacqueline Wyatt, Andrew Watt
  • Antisense modulation of matrix metalloproteinase 1 expression
    Publication number: 20060074043
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of matrix metalloproteinase 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding matrix metalloproteinase 1. Methods of using these compounds for modulation of matrix metalloproteinase 1 expression and for treatment of diseases associated with expression of matrix metalloproteinase 1 are provided.
    Type: Application
    Filed: October 13, 2005
    Publication date: April 6, 2006
    Inventors: Brett Monia, Susan Freier, Sanjay Bhanot, Madeline Butler, Andrew Watt, Jacqueline Wyatt, Brenda Baker, Lex Cowsert, Kenneth Dobie
  • Antisense modulation of c/ebp beta expression
    Publication number: 20060030045
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of C/EBP beta. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding C/EBP beta. Methods of using these compounds for modulation of C/EBP beta expression and for treatment of diseases associated with expression of C/EBP beta are provided.
    Type: Application
    Filed: June 11, 2001
    Publication date: February 9, 2006
    Inventors: Brett Monia, Madeline Butler, Jacqueline Wyatt
  • Compositions and their uses directed to bone growth modulators
    Publication number: 20060003953
    Abstract: Disclosed herein are compounds, compositions and methods for modulating the expression of a bone growth modulator in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.
    Type: Application
    Filed: December 3, 2004
    Publication date: January 5, 2006
    Inventors: C. Bennett, Madeline Butler, Nicholas Dean, Kenneth Dobie, Joshua Finger, Ravi Jain, Robert McKay, Brett Monia, Kathleen Myers
  • Antisense modulation of TFAP2C expression
    Publication number: 20050227938
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of TFAP2C. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding TFAP2C. Methods of using these compounds for modulation of TFAP2C expression and for treatment of diseases associated with expression of TFAP2C are provided.
    Type: Application
    Filed: December 17, 2004
    Publication date: October 13, 2005
    Inventors: C. Bennett, Brenda Baker, Nicholas Dean, Brett Monia, Susan Freier, James Karras, Hong Zhang, Susan Murray, Madeline Butler, Erich Koller, Thomas Condon, William Gaarde, Andrew Watt, Mark Graham, Jacqueline Wyatt, Lex Cowsert, Kenneth Dobie, Mark Roach
  • Antisense modulation of interferon gamma receptor 2
    Publication number: 20050153924
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of Interferon gamma receptor 2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Interferon gamma receptor 2. Methods of using these compounds for modulation of Interferon gamma receptor 2 expression and for treatment of diseases associated with expression of Interferon gamma receptor 2 are provided.
    Type: Application
    Filed: December 15, 2004
    Publication date: July 14, 2005
    Inventors: C. Bennett, Brett Monia, Susan Murray, Madeline Butler, Nicholas Dean, Rosanne Crooke, Mark Graham, Hong Zhang, Susan Freier, Brenda Baker, Eric Marcusson, Jacqueline Wyatt, Lex Cowsert, Kenneth Dobie, Andrew Watt
  • Antisense modulation of PTP1B expression
    Publication number: 20050095710
    Abstract: Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.
    Type: Application
    Filed: December 9, 2004
    Publication date: May 5, 2005
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Lex Cowsert, Jacqueline Wyatt, Susan Freier, Brett Monia, Madeline Butler, Robert McKay
  • Chimeric oligomeric compounds comprising alternating regions of northern and southern conformational geometry
    Publication number: 20050074801
    Abstract: The present invention relates to novel chimeric oligomeric compounds having a plurality of alternating regions having either RNA like having northern or 3?-endo conformational geometry (3?-endo regions) or DNA like having southern or C2?-endo/O4?-endo conformational geometry. The oligomeric compounds of the present invention have shown reduction in mRNA levels in multiple in vitro and in vivo assay systems and are useful, for example, for investigative and therapeutic purposes.
    Type: Application
    Filed: September 8, 2004
    Publication date: April 7, 2005
    Inventors: Brett Monia, Madeline Butler, Robert McKay, Brenda Baker