Patents by Inventor Madeline Cox

Madeline Cox has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240401064
    Abstract: A bacteria-mediated platform that uses invasive, non-pathogenic bacteria to both produce and intracellularly deliver antibodies, antibody derivatives, and proteins/polypeptides to targeted eukaryotic cells and tissues. The bacteria can contain a prokaryotic expression cassette encoding the protein cargo.
    Type: Application
    Filed: June 2, 2022
    Publication date: December 5, 2024
    Applicant: SiVEC Biotechnologies, Inc.
    Inventors: Lyndsey M Linke, Ashley B Williams, Darcy Mora, Madeline Cox, Timothy Enroth
  • Publication number: 20210222178
    Abstract: A bacterial system for the generation and delivery of eukaryote-translatable mRNA to eukaryotic cells. The system uses invasive, non-pathogenic bacteria to generate and deliver functional mRNA cargo to eukaryotic cells. Additionally, the system uses bacteria to generate functional mRNA that can be extracted from the bacterial cell for downstream applications. The bacteria contain at least one prokaryotic expression cassette encoding the mRNA; the mRNA contains a bacterially transcribed poly-A sequence, and a 5? cap or pseudo-cap element, e.g., an internal ribosome entry site (IRES) element, that will mediate translation in the eukaryotic host cell. Examples of therapeutic mRNA function include, but are not limited to, providing genetic material encoding antibodies, vaccine antigens, and defective genes in the host.
    Type: Application
    Filed: January 11, 2021
    Publication date: July 22, 2021
    Applicant: SiVEC Biotechnologies LLC
    Inventors: Lyndsey M. Linke, Ashley B. Williams, Darcy Mora, Madeline Cox