Patents by Inventor Madhav V Dhodapkar

Madhav V Dhodapkar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • In vivo expanded NKT cells and methods of use thereof
    Patent number: 7837990
    Abstract: This invention relates to the in vivo expansion of NKT cells by their exposure to mature dendritic cells expressing ?-galactosyl ceramide and to methods of use thereof in modulating immune responses, such as anti-cancer responses, and enhancing memory responses.
    Type: Grant
    Filed: March 20, 2006
    Date of Patent: November 23, 2010
    Assignees: The Rockefeller University, Kyowa Hakko Kirin, Co., Ltd.
    Inventors: Madhav V Dhodapkar, Ralph M. Steinman
  • USE OF IMMATURE DENDRITIC CELLS TO SILENCE ANTIGEN SPECIFIC CD8+ T CELL FUNCTION
    Publication number: 20090175890
    Abstract: This invention provides methods for silencing a pre-existing immune response in a mammal, as for example, in the setting of autoimmune diseases. The method comprises administering to a mammal immature dendritic cells which have been contacted in vitro with an antigen, or to target the antigen to immature dendritic cells in vivo, in order to silence and/or suppress a pre-existing CD8+ T cell immune response and induce IL-10 producing CD8+ T cells in said mammal. This invention further relates to methods for propagating immature dendritic cells, for maintaining immaturity by modification ex vivo, and uses thereof, including generation of regulatory T cells for passive immunotherapy. The present invention also relates to compositions and kits comprising immature dendritic cells and antigens.
    Type: Application
    Filed: December 30, 2008
    Publication date: July 9, 2009
    Inventors: Madhav V. Dhodapkar, Ralph M. Steinman, Nina Bhardwaj
  • Use of immature dendritic cells to silence antigen specific cd8cell function
    Publication number: 20040109851
    Abstract: This invention provides methods for silencing a pre-existing immune response in a mammal, as for example, in the setting of autoimmune diseases. The method comprises administering to a mammal immature dendritic cells which have been contacted in vitro with an antigen, or to target the antigen to immature dendritic cells in vivo, in order to silence and/or suppress a pre-existing CD8+T cell immune response and induce IL-10 producing CD8+T cells in said mammal. This invention further relates to methods for propagating immature dendritic cells, for maintaining immaturity by modification ex vivo, and uses thereof, including generation of regulatory T cells for passive immunotherapy. The present invention also relates to compositions and kits comprising immature dendritic cells and antigens.
    Type: Application
    Filed: December 23, 2003
    Publication date: June 10, 2004
    Inventors: Madhav V. Dhodapkar, RalphM M Stein, Nina Bhardwaj