Patents by Inventor Madhavi Sriram

Madhavi Sriram has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combretastatin analogs with tubulin binding activity
    Patent number: 8394859
    Abstract: Analogs of combretastatin have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin polymerization. Such compounds are excellent clinical candidates for the treatment of cancer in humans. In addition, certain of these ligands, as pro-drugs, may well prove to be tumor selective vascular targeting chemotherapeutic agents or to have vascular targeting activity resulting in the selective prevention and/or destruction of nonmalignant proliferating vasculature.
    Type: Grant
    Filed: August 22, 2008
    Date of Patent: March 12, 2013
    Assignee: Baylor University
    Inventors: Kevin G. Pinney, Madhavi Sriram
  • Efficient Method for Preparing Functionalized Benzosuberenes
    Publication number: 20120130129
    Abstract: The disclosed process can efficiently synthesize functionalized benzosuberenes. The process provides an improved method of production of benzosuberene and compounds containing a benzosuberene moiety, which is characterized by a ring closing methodology comprising reaction of a 5-phenylpentanoic acid with Eaton's reagent to form the benzosuberone. The process, optionally, further includes steps for adding a functional group at the ketone position.
    Type: Application
    Filed: November 16, 2011
    Publication date: May 24, 2012
    Applicant: BAYLOR UNIVERSITY
    Inventors: Kevin G. Pinney, Madhavi Sriram, Clinton George, Rajendra P. Tanpure
  • Combretastatin Analogs with Tubulin Binding Activity
    Publication number: 20090075943
    Abstract: Analogs of combretastatin have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin polymerization. Such compounds are excellent clinical candidates for the treatment of cancer in humans. In addition, certain of these ligands, as pro-drugs, may well prove to be tumor selective vascular targeting chemotherapeutic agents or to have vascular targeting activity resulting in the selective prevention and/or destruction of nonmalignant proliferating vasculature.
    Type: Application
    Filed: August 22, 2008
    Publication date: March 19, 2009
    Inventors: Kevin G. PINNEY, Madhavi Sriram
  • Combretastatin analogs with tubulin binding activity
    Patent number: 7429681
    Abstract: Analogs of combretastatin have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin polymerization. Such compounds are excellent clinical candidates for the treatment of cancer in humans. In addition, certain of these ligands, as pro-drugs, may well prove to be tumor selective vascular targeting chemotherapeutic agents or to have vascular targeting activity resulting in the selective prevention and/or destruction of nonmalignant proliferating vasculature.
    Type: Grant
    Filed: June 14, 2006
    Date of Patent: September 30, 2008
    Assignee: Baylor University
    Inventors: Kevin G. Pinney, Madhavi Sriram
  • Combretastatin analogs with tubulin binding activity
    Publication number: 20060293394
    Abstract: Analogs of combretastatin have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin polymerization. Such compounds are excellent clinical candidates for the treatment of cancer in humans. In addition, certain of these ligands, as pro-drugs, may well prove to be tumor selective vascular targeting chemotherapeutic agents or to have vascular targeting activity resulting in the selective prevention and/or destruction of nonmalignant proliferating vasculature.
    Type: Application
    Filed: June 14, 2006
    Publication date: December 28, 2006
    Inventors: Kevin Pinney, Madhavi Sriram